Amy Wiles, PhD
Using a systems biology approach, Amy is investigating Drosophila genes required for viability after DNA damage and is integrating this data with genetic and protein-protein interactions. Also, she is studying the effect of the Werner helicase on genetic stability and premature aging in mice.

Ravi Dashamoorthy, PhD
Ravi's interest to is validate the hits generated from the RNAi based genomewide screen for cell viability following damage exposures in the Drosophila cells and classify the hits based on phenotypes such as cell proliferation, apoptosis and DNA damage. In addition, he is also studying the role of oxidative stress as component that modifies the network response following the damage exposures.

Ting Ting Gu, MD
Ting Ting is the Lab manger, she co-ordinates the major tasks such high throughput production of dsRNA for the RNAi screen, constructs plasmid vectors for all researchers in the lab, maintenance and ordering of lab supplies. Ting Ting has over fifteen years of research experience, as an important team player she works towards the success of our various research programs.

Adam Brown
Adam’s research interests include DNA repair and how it relates to genome integrity and cancer biology. He is working with a number of different mouse models to test their effectiveness as biomarkers for detecting and quantifying homologous recombination events. Such models include the pink-eyed unstable (p un) and fluorescent yellow direct repeat (FYDR). Adam’s primary objectives are the establishment of retinal pigment epithelial (RPE) cell cultures from these different mouse models and further advancement of in vivo detection in the FYDR system. Adam is also working with the Bloom’s syndrome mouse model, which is an example of a genetic disorder that leads to an increase in genome instability and predisposition to various cancers.