Alex Bishop, D.Phil., joined the Greehey Children’s Cancer Research Institute in September of 2004 with major faculty responsibilities as a Principal Investigator in Molecular Oncogenesis. He is also an Assistant Professor in the Department of Cellular and Structural Biology and a member of both the Cancer Therapy and Research Center (a NCI-designated cancer center). He received his doctoral degree from Oxford University and completed two post-doctoral fellowships at Harvard University.
Dr. Bishop is a molecular geneticist whose research focuses on DNA damage responses and the resultant genomic instability, a fundamental cause of cancer. His laboratory is involved in two major lines of research, discovering new genes and pathways involved in damage survival and understanding how damage survival genes affect maintenance of genomic integrity via the homologous recombination process. The goal is to apply the knowledge gained to the treatment of cancer. This work has several important applications, including improving our understanding of the basic biology of cellular processes, providing insights into cancer etiology and progression and identifying prognostics for cancer treatment as well as developing novel treatment strategies.
Recent Publications:
Lee et al. Atg7 modulates p53 activity to regulate cell cycle and survival during metabolic stress. Science 2012 Apr; 336(6078): 225-228
Zimmer et al. Mice heterozygous for CREB binding protein are hypersensitive to γ-radiation and invariably develop myelodysplastic/myeloproliferative disease Experimental Hematology 2012 Apr; 40(4): 295-306
Lin et al. Journal of Biological Chemistry 2011 Dec; 286(51): 44023-44034
Brown et al. Developing a conditional mouse model for measuring the effect of essential genes on the frequency of homologous recombination events in vivo. Molecular and Cellular Biology 2011; 31(17):3593-602
| 2010 | Cellular and Structural Biology Award for Excellence in Graduate Student Education: Award for teaching contributions to the Department. |
| 2010 | Voelcker Fund Young Investigator Award |
| 2009 | NCI Travel Award: Award to attend and present at the 3rd US-EU workshop Systems Biology of the DNA Damage Response |
| 2004 | K22 Transitions to Independent Positions: Fellowship from NIEHS (NIH). |
| 2002 | Keystone Scholarship: Scholarship to Replication and Recombination Conference |
| 2001 | Keystone Scholarship: Scholarship to Molecular Basis of Cancer Conference |
| 1999 | ASM Travel Grant: Award to attend ASM DNA repair meeting |
| 1999 | Keystone Scholarship: Scholarship to attend Molecular Basis of Cancer Conference |
| 1997 | F32 Postdoctoral Fellowship: Fellowship from NIGMS (NIH) |
| 1997 | ACS Postdoctoral Fellowship (not accepted due to F32 Fellowship award) |
| 1993 | MRC (UK) Graduate Student Fellowship: Fellowship for PhD studies |
2011 - Present Academic Editor PLoS ONE
2011 - Present Associate Member of the Children’s Oncology Group
2010 - Present American Association for Cancer Research (116260)
2010 - Present Environmental Mutagen Society
2005 - Present Mbr. of the Nathan Shock Aging Center & Barshop Inst.
2005 - Present Member of Cancer Therapy and Research Institute
2000 - Present American Society for Microbiology (554456533)
1995 - 1997 UK Genetical Society
Current: |
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| NIH NCI: 1R01CA152063-01A1 | LINK | Period: 09/2011 - 07/2016 |
| NIH NIEHS: 1R15ES019128-01 | LINK | Period: 04/2010 - 03/2013 |
| Voelcker Fund Young Investigator Award |
LINK | Period: 07/2010 - 06/2013 |
| USAMRAC (Student fellowship to Karia): BC093931 |
LINK | Period: 01/2010 - 12/2012 |
| NIH NIA (Student fellowship to Brown): 5T32AG021890 | LINK | Period: 05/2008 - 04/2013 |
| Greehey Graduate Fellowship Award (Student fellowship to Gorthi): BC093931 | LINK | Period: 09/2011 - 08/2012 |
| Helen Freeborn Kerr Charitable Foundation Award | Period: 09/2011 - 04/2012 | |
| GCCRI Ambassador’s Circle Research Support Award | Period: 02/2012 - 01/2013 | |
Completed: |
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| NIH NIEHS: K22ES12264 | LINK | Period: 09/2004 - 05/2010 |
| CTRC: 128253 | Period: 12/2008 - 04/2010 | |
| Nathan Shock Institute: 121295 | Period: 07/2005 - 06/2006 | |
| American Cancer Society: 122295 | Period: 08/2005 - 08/2006 | |
Teaching:
Dr. Bishop takes an active part in teaching at UTHCSA, is director of Cancer Biology Core I and Module co-director for the Advanced Cell and Molecular Biology course amongst other teaching responsibilities.
