The Tumor Virology Program (TVP) of the Greehey Children’s Cancer Research Institute seeks to develop a world-class program of excellence focusing on viral oncogenesis. TVP is dedicated to cutting edge discovery and research, and innovative approaches for deciphering the molecular mechanisms by which viruses evade host antiviral defenses, and promote cell growth and survival through the stimulation of oncogenic/mitogenic pathways, inhibition of tumor suppressor pathways and regulation of cellular gene transcription. TVP intends to foster, connect, stimulate and enhance cohesive multidisciplinary research and clinical programs within and beyond the Greehey Children’s Cancer Research Institute, San Antonio Cancer Institute, and the University of Texas Health Science Center at San Antonio.
Kaposi's sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus 8 (HHV8), is the most recently discovered human herpesvirus. KSHV has been etiologically associated with the development of Kaposi's sarcoma (KS), a vascular spindle cell disease frequently occurring in persons with AIDS, and several other malignancies including primary effusion lymphoma (PEL) and a subset of multicentric Castleman's disease (MCD). The primary focus of Dr. Gao’s laboratory is to understand the epidemiology and molecular mechanism of KSHV-related pathogenesis, providing a biologic basis for preventative and therapeutic purposes.
Cell Model & Genetic Manipulation System
Delineation of KSHV Transformation Genes
Functional Studies of KSHV Latent Nuclear Antigen
Functional Studies of Viral Interferon Regulatory Factor
Isolation & Characterization of Lytic
KSHV Epidemiology