Faculty

 

The Greehey Children's Cancer Research Institute and the faculty have created a specialized cancer and research center that focuses on advancing scientific knowledge relevant to childhood cancer and accelerating that knowledge into innovative cures for all ages.

 

Dr. Aune

Gregory J. Aune, MD, PhD

Our overall goal is to use preclinical laboratory models to elucidate the basic mechanisms of organ damage caused by pediatric cancer treatments.

Dr. Bishop

Alexander J.R. Bishop, DPhil

The interest of our lab is to identify and understand mechanisms of damage survival. People who inherit a deficiency in damage response are predisposed to develop cancer, usually as children or young adolescents. Further, most cancer treatments are based on damaging cancer cells, so understanding why a chemotherapy works, and for which patients, should lead to more effective and less toxic treatments that will increase the cure rate and improve quality of life for cancer survivors.

Dr. Chen

Yidong Chen, PhD

Computational Biology and Bioinformatics (CBBI) focuses on developing computational solution and statistical modeling to bridge between quatitative science and the basic biology and translational research within Greehey Children’s Cancer Research Institute and around UT Health San Antonio.

Dr. Gupta

Yogesh Gupta, PhD

The research efforts of my laboratory have focused on understanding the structure and function of large protein-nucleic acid assemblies that play central role in normal homeostasis and childhood cancers. Our studies would facilitate the development of novel anti-cancer agents to target specific steps in the oncogenic process with minimal impact on normal cell function.

Dr. Hougthon

Peter Houghton, PhD

Our studies are aimed at understanding mechanisms of cancer initiation in children and using this information to develop more effective and less toxic treatments that will increase the cure rate and improve quality of life for cancer survivors.

Dr.Ignatius

Myron Ignatius, PhD

Discover novel treatments in relapsed pediatric cancer by defining tumor heterogeneity and its effect on self-renewal and metastasis.

Dr. Kitagawa

Katsumi Kitagawa, PharmD, PhD

Our research goal is to understand the role of aneuploidy (chromosome loss or gain) in childhood cancer development. We are currently investigating the mechanism of CIN (chromosome instability) in pediatric tumors.

Dr. Kurmasheva

Raushan Kurmasheva, PhD

Our research is focused on understanding the mechanisms of resistance of Ewing sarcoma cells to PARP1 inhibition with the ultimate goal of developing more effective and less toxic therapy for Ewing sarcoma patients. Another project in which the lab is involved identifies novel drugs and drug combinations to treat pediatric sarcoma and renal tumors. This project is a part of the Pediatric Preclinical Testing Consortium (PPTC) that has been recently funded by NCI.

Dr. Lai

Zhao Lai, PhD

Dr. Zhao Lai is Director of Genome Sequencing Facility (GSF) in the Greehey Children’s Cancer Research Institute (Greehey CCRI) at UT Health San Antonio. The GSF utilizes state-of-the-art genomic platforms to generate high-quality genomic data and provides support with its analysis to scientists of GCCRI, UT Health Cancer Center, UT Health San Antonio and surrounding San Antonio areas.

Dr. Libich

David Libich, PhD

Targeting specific protein interactions can provide unique targets for the treatment of many cancers, yet one major obstacle to this therapeutic approach is the lack of high-resolution structural details of the macromolecular partners often due to their size, disorder and dynamic nature. The Libich laboratory employs unique NMR tools that now allow the structures and dynamics of such interactions, even in large complexes, to be resolved.

Dr. Penalva

Luiz O. F. Penalva, PhD

My laboratory studies post-transcriptional regulation from a global perspective. We use a combination of genomics, systems biology, biochemistry, bioinformatics and molecular biology to investigate the networks formed by RNA binding proteins, miRNAs and their target genes and evaluate their impact on biological processes, cancer and disease states.

Dr. Pertsemlidis

Alexander Pertsemlidis, PhD

Our research interests integrate computational biology, cancer biology and genetics. We study regulatory RNA molecules called non-coding RNAs (called that because they do not code for proteins), including microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), and how they regulate cancer cell growth and response to anti-cancer drugs.

Dr. Rao

Manjeet K. Rao, PhD

Research in my laboratory is directed towards developing new, more efficacious and less toxic treatments for childhood cancers.

Dr. Shiio

Yuzuru Shiio, MD, PhD

Employing a combination of proteomics and molecular cell biology approaches, we study the cytokines secreted from senescent cells and children’s cancers and the oncoproteins driving children’s cancers.

Dr. Tomlinson

Gail Tomlinson, MD, PhD

Our studies are aimed at understanding the underlying genetic basis of pediatric cancers with the goal of applying genetic knowledge to cancer prevention and control.

Dr. Zheng

Siyuan Zheng, PhD

We are a bioinformatics and computational biology lab with a focus on the analysis of cancer genomic and proteomic data. Our goal is to improve our understanding of adult and pediatric cancer through innovative and integrative analyses. We are especially interested in telomere and telomerase, a pair that is of central importance to cancer initiation.