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SUNDAY, MARCH 3rd 2019
7:00pm - 9:00pm
Dr. Peter Houghton
Director, Greehey Children's Cancer Research Institute - UT Health San Antonio
MONDAY, MARCH 4th 2019
SESSION ONE: Genomics
8:15am - 1:30pm
7:30am - 8:30am
Peter Houghton, PhD
Director, Greehey CCRI, UT Health San Antonio
8:15am - 8:30am
David Malkin, MD, FRCP(C), FAAP
"Li-Fraumeni Syndrome: The Potential of Genomics in Early Tumor Detection and Prevention"
8:30am - 9:10am
Charles G. Mullighan, MBBS (Hons), MSC, MD
St. Jude Children's Research Hospital
"Genetics, Risk and Acute Lymphoblastic Leukemia"
9:10am - 9:50am
9:50am - 10:10am
Paul S. Meltzer, MD, PhD
"Searching for Biological Insights and Clinical Opportunities in the Complex Genomes of Osteosarcoma"
10:10am - 10:50am
Marc Remke, MD, PhD
University of Dusseldorf
"Intergrative Pharmacogenomic Profiling Reveals Novel Therapeutic Vulnerabilities in Pediatric Brain Tumors"
10:50am - 11:30am
UT Health San Antonio
"Synonymous But Not Silent: A Synonymous VHL Variant Confers Susceptibility to Familial Pheochromocytomas and VHL Disease"
1:00pm - 1:15pm
" Synthetic Lethality Between MYCN Amplification and ATRX Mutations in Neuroblastoma"
1:15pm - 1:30pm
SESSION TWO: Epigenetics & Pathways in Pediatric Cancer
1:30pm - 4:30pm
Charles W.M. Roberts, MD, PhD
"SSWI/SNF (BAF) Chromatin Remodeling Complexes are Frequently Mutated in Cancer: Mechanisms and Vulnerabilities"
1:30pm - 2:10pm
Eleanor Chen, MD, PhD
University of Washington
"Targeting epigenetic drivers in rhabdomyosarcoma"
2:10pm - 2:50pm
2:50pm - 3:10pm
Greehey CCRI, UT Health San Antonio
"Cause and Consequences of R-Loop Accumulation in Ewing Sarcoma"
3:10pm - 3:50pm
Stephen L. Lessnick, MD, PhD
Nationwide Children's Hospital
"Genomic Junk, EWS/FLI’s Treasure?"
3:50pm - 4:30pm
SESSION THREE: Poster Session
4:30pm - 7:00pm
TUESDAY, MARCH 5th 2019
SESSION FOUR: Immunotherapy
8:30am - 12:00pm
7:30am - 8:30pm
Brigitte Widemann, MD
"Optimizing the development of effective therapies for children and young adults with cancers or genetic tumor predisposition syndromes"
Paul M. Sondel, MD, PhD
University of Wisconsin-Madison
"Engaging Innate and Adaptive Immunity Against Pediatric Solid Tumors"
10:00 - 10:20pm
Terry Fry, MD
University of Colorado
"Addressing the Holes in Highly Active CAR T Therapy: T Cell Persistence and Leukemic Resistance"
Crystal Mackall, MD
"CAR T cells for Pediatric cancers: Progress and Challenges"
11:00am - 11:40am
12:00 - 1:00pm
Johns Hopkins University
"The Immunosuppressive Tumor Microenvironment of Metastatic Osteosarcoma Inhibits the Cytotoxic Effect of Tumor-Infiltrating Lymphocytes"
"FGL2 Expression by Tumor Cells in the CNS Impairs Systemic Adaptive Anti-Tumor Immune Response by Suppressing CD103+ Dendritic Cell Differentiation"
Michael C V Jensen,MD
Seattle Children's Research Institute
"Advancing CAR T Cell Therapies in the Pediatric Oncology Clinic"
SESSION FIVE: Advocacy & Outcomes (Roundtable Style)
2:10pm - 3:45pm
Greg Aune, MD, PhD
Susan L. Weiner, PhD
Children's Cause Cancer Advocacy
Kevin C. Oeffinger, MD
Saro H. Armenian, DO, MPh
City of Hope
WEDNESDAY, MARCH 6th 2019
SESSION SIX: THERAPY & Drug Discovery
8:30am - 11:30am
7:30am - 8:30am
Kimberly Stegmaier, PhD
Dana-Farber Cancer Institute
"Path to New Pediatric Oncology Therapies"
Louis F. Stancato, PhD
"A translational research approach to identifying drugs to fight childhood cancer"
Craig M. Crews, PhD
"PROTAC-mediated Protein Degradation: A New Therapeutic Modality"
9:50am - 10:30am
Cigall Kadoch, PhD
Harvard Medical School
"Structure and :Function of Mammalian SWI/SNF Chromatin Remodeling Complexes in Human Disease"
"Increasing Therapeutic Options for Relapsed and High Risk Pediatric Solid Tumor Patients Through Deep Sequencing of DNA and RNA"
"RNA Demethylase ALKBH5 as a Novel Therapeutic Target for Osteosarcoma"
MARCH 3rd - MARCH 6th
UT Health San Antonio -
Cancer Research Institute
8403 Floyd Curl Drive
San Antonio, TX 78229
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