The mRNA Metabolism in Human Disease: The diverse roles of RNA-binding proteins in glioma development
Abstract
Post-transcriptional regulation of gene expression is fundamental for all forms of life, as it critically contributes to the composition and quantity of a cell’s proteome. These processes encompass splicing, polyadenylation, mRNA decay, mRNA editing, and modification and translation and are modulated by a variety of RNA-binding proteins (RBPs). Alterations affecting RBP expression and activity contribute to the development of different types of cancer. In this chapter, we discuss current research shedding light on the role of different RBPs in gliomas. These studies place RBPs as modulators of critical signaling pathways, establish their relevance as prognostic markers, and open doors for new therapeutic strategies.
Keywords
ADARs Cancer Glioblastoma hnRNP HuR IGF2BPs Musashi1 PTBP RNA-binding proteins Translation initiation
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