Fraternal Order of Eagles: People Helping People

May 18, 2018

2016-17 Texas State Presidents Ron Poling and Rachel Graham were proud to present a check for $50,000 to Dr. Houghton, Director of the Greehey Children’s Cancer Research Institute at the University of Texas Health Science Center in San Antonio. Ron and Rachel would like to thank all the Texas State Aerie and Auxiliary members for […]


Nature Genetics: Discordant inheritance of chromosomal and extrachromosomal DNA elements contributes to dynamic disease evolution in glioblastoma

April 23, 2018

Ana C deCarvalho 1, Hoon Kim 2, Laila M Poisson 3, Mary E Winn 4, Claudius Mueller 5, David Cherba 4, Julie Koeman 6, Sahil Seth 7, Alexei Protopopov 7, Michelle Felicella 8, Siyuan Zheng 9, Asha Multani 10, Yongying Jiang 7, Jianhua Zhang 7, Do-Hyun Nam 11 12 13, Emanuel F Petricoin 5, Lynda Chin 7 9, Tom Mikkelsen 14 15, Roel G W Verhaak 16 Abstract To understand how genomic heterogeneity of glioblastoma (GBM) contributes to poor therapy response, we performed DNA and RNA sequencing on GBM samples and the neurospheres and orthotopic xenograft […]




International Journal of Mass Spectrometry: Comprehensive and sensitive proteogenomics data analysis strategy based on complementary multi-stage database search

April 1, 2018

Inamul Hasan Madar, Wonyeop Lee, Xiaojing Wang, Seung-Ik Ko, Hokeun Kim, Dong-Gi Mun, Bing Zhang, Eunok Paek, Sang-Won Lee Proteogenomics provides opportunities for proteomic validation of gene structures, genomic alterations, and functional relevance of novel findings obtained from genomic data analysis. However, for effective proteogenomic data integration, an extensive proteome profiling, approaching the gene coverage […]


Journal of Pediatric Hematology/Oncology: Aerobic Exercise During Early Murine Doxorubicin Exposure Mitigates Cardiac Toxicity

April 1, 2018

Wang, Fei PhD*; Iskra, Brian BS†; Kleinerman, Eugenie MD*; Alvarez-Florez, Claudia PhD*; Andrews, Thomas MSc†; Shaw, Angela MD*; Chandra, Joya PhD*; Schadler, Keri PhD*; Aune, Gregory J. MD, PhD†,‡ Abstract We report the cardioprotective effects of moderate aerobic exercise from parallel pediatric murine models of doxorubicin (Doxo) exposure in non–tumor-bearing immune-competent (NTB-IC) mice and tumor-bearing nude mice (TB-NM). […]


Technology Networks: Link Discovered Between BRCA1 Protein and Aggressive Pediatric Cancer

March 8, 2018

Scientists with the Greehey Children’s Cancer Research Institute at UT Health San Antonio have discovered a surprising connection between a breast cancer protein, BRCA1, and pediatric cancer called Ewing sarcoma. Their findings, reported March 7 in the journal Nature, reveal a completely new mechanism by which BRCA1 can be rendered dysfunctional. “The observations raise many new […]


UT Health SA Newsroom: Greehey Institute team finds link between BRCA1 and Ewing sarcoma

March 7, 2018

A mutant oncogene in Ewing traps BRCA1 and prevents it from repairing genetic damage. Scientists with the Greehey Children’s Cancer Research Institute at UT Health San Antonio have discovered a surprising connection between a breast cancer protein, BRCA1, and a pediatric cancer called Ewing sarcoma. Their findings, reported March 7 in the journal Nature, reveal a completely new mechanism […]


EurekAlert: Greehey Institute team finds link between BRCA1 and Ewing sarcoma

March 7, 2018

Scientists with the Greehey Children’s Cancer Research Institute at UT Health San Antonio have discovered a surprising connection between a breast cancer protein, BRCA1, and a pediatric cancer called Ewing sarcoma. Their findings, reported March 7 in the journal Nature, reveal a completely new mechanism by which BRCA1 can be rendered dysfunctional. “The observations raise many new […]


Life Extension Advocacy Foundation: Greehey Institute team finds link between BRCA1 and Ewing sarcoma

March 7, 2018

Scientists with the Greehey Children’s Cancer Research Institute at UT Health San Antonio have discovered a surprising connection between a breast cancer protein, BRCA1, and a pediatric cancer called Ewing sarcoma. Their findings, reported March 7 in the journal Nature, reveal a completely new mechanism by which BRCA1 can be rendered dysfunctional. “The observations raise many new […]