Research Paper

Cancer Research: A Very Long-Acting PARP Inhibitor Suppresses Cancer Cell Growth in DNA Repair-Deficient Tumor Models (Houghton, Kurmasheva)

February 19, 2021

Shaun D. Fontaine, Gary W. Ashley, Peter J. Houghton, Raushan T. Kurmasheva, Morgan Diolaiti, Alan Ashworth, Cody J. Peer, Ryan Nguyen, William D. Figg Sr., Denis R. Beckford-Vera, and Daniel V. Santi Abstract PARP inhibitors are approved for the treatment of cancers with BRCA1 or BRCA2 defects. In this study, we prepared and characterized a […]

Cancer Letters: Androgen deprivation-induced elevated nuclear SIRT1 promotes prostate tumor cell survival by reactivation of AR signaling

February 19, 2021

Author links open overlay panels high-BoHuanga, D.Thapaa, A.R.Munoza, S.S.Hussaina, X.Yanga, R.G.Bedollaa, P.Osmulskib, M.E.Gaczynskab, Z.Laibg, Yu-ChiaoChiug, Li-JuWanggY.Chendfg, P.Rivasa, C.Shuddea, R.L.Reddickc, H.Miyamotoh, R.Ghoshabf, A.P.Kumarabef1 Highlights •  High nuclear SIRT1 (nSIRT1) levels were associated with a significantly increased risk of prostate cancer progression. •  Androgen deplete conditions increased nuclear accumulation of SIRT1 protein. •  SIRT1 suppression impacts distinct […]

Clinical Cancer Research: The B7-H3-targeting antibody-drug conjugate m276-SL-PBD is potently effective against pediatric cancer preclinical solid tumor models

February 15, 2021

Nathan M. Kendsersky, Jarrett M Lindsay, Edward A. Kolb, Malcolm A. Smith, Beverly A. Teicher, Stephen Erickson, Eric J Earley, Yaël P. Mossé, Daniel Martinez, Jennifer Pogoriler, Kateryna Krytska, Khushbu Patel, David Groff, Matthew Tsang, Samson Ghilu, Yifei Wang, Steven Seaman, Yang Feng, Brad St. Croix, Richard Gorlick, Raushan T. Kurmasheva, Peter J. Houghton and John M. Maris Abstract Purpose: Patients with relapsed pediatric solid malignancies have few therapeutic options, and many of these patients die of their disease. B7-H3 is an immune checkpoint protein encoded by the CD276 gene that is overexpressed in many pediatric cancers. Here, we investigate the […]

Oncogene: MNK1 and MNK2 enforce expression of E2F1, FOXM1, and WEE1 to drive soft tissue sarcoma

February 9, 2021

Xin-Yu Ke, Ye Chen, Valarie Yu-Yan Tham, Ruby Yu-Tong Lin, Pushkar Dakle, Kassoum Nacro, Mark Edward Puhaindran, Peter Houghton, Angela Pang, Victor Kwanmin Lee, Ling-Wen Ding, Sigal Gery, Jeffrey Hill, Leilei Chen, Liang Xu & H. Phillip Koeffler Abstract Soft tissue sarcoma (STS) is a heterogeneous disease that arises from connective tissues. Clinical outcomes of patients […]

Cell Press: A Modular Master Regulator Landscape Controls Cancer Transcriptional Identity (Zheng Lab)

January 21, 2021

Evan O.Paull114,  Alvaro Aytes121314,  Sunny J.Jones114,  Prem S.Subramaniam1,  Federico M.Giorgi3,  Eugene F.Douglass1,  Somnath Tagore1,  Brennan Chu1,  Alessandro Vasciaveo1,  Siyuan Zheng4,  Roel Verhaak5,  Cory Abate-Shen1678,  Mariano J.Alvarez19,  Andrea Califano16910111215 Summary Despite considerable efforts, the mechanisms linking genomic alterations to the transcriptional identity of cancer cells remain elusive. Integrative genomic analysis, using a network-based approach, identified 407 […]

Methods: Prediction and interpretation of cancer survival using graph convolution neural networks

January 21, 2021

RicardoRamireza, Yu-ChiaoChiub, SongYaoZhangc, JoshuaRamireza, YidongChenbd, YufeiHuangad, Yu-FangJina Highlights •  Predicting cancer survival outcomes using Graph Convolutional Neural Networks with TCGA dataset. •  Combining clinical data and the GCNN improves cancer prognostic prediction. •  Interpreting the GCNN model and identifying significant genes with network modules identified by HotNet2. Abstract The survival rate of cancer has increased […]

MDPI: Synergism of Proneurogenic miRNAs Provides a More Effective Strategy to Target Glioma Stem Cells (Penalva & Pertsemlidis Labs)

January 14, 2021

Adam Kosti, Rodrigo Barreiro, Gabriela D. A. Guardia, Shiva Ostadrahimi, Erzsebet Kokovay, Alexander Pertsemlidis, Pedro A. F. Galante, Luiz O. F. Penalva Simple Summary miRNAs function as critical regulators of gene expression and have been defined as contributors to cancer phenotypes by acting as oncogenes or tumor suppressors. Based on these findings, miRNA-based therapies have been explored in the treatment of many […]

BMC Microbiology: Comparison of rectal swab, glove tip, and participant-collected stool techniques for gut microbiome sampling

January 14, 2021

Meghan I. Short, Robert Hudson, Benjamin D. Besasie, Kelly R. Reveles, Dimpy P. Shah, Susannah Nicholson, Teresa L. Johnson-Pais, Korri Weldon, Zhao Lai, Robin J. Leach, Bernard Fongang & Michael A. Liss Abstract Background Studies of the gut microbiome are becoming increasingly important. Such studies require stool collections that can be processed or frozen in a […]

Nature Communications: Interaction between SNAI2 and MYOD enhances oncogenesis and suppresses differentiation in Fusion Negative Rhabdomyosarcoma (Ignatius, Houghton, Chen)

January 14, 2021

Silvia Pomella, Prethish Sreenivas, Berkley E. Gryder, Long Wang, David Milewski, Matteo Cassandri, Kunal Baxi, Nicole R. Hensch, Elena Carcarino, Young Song, Hsien-Chao Chou, Marielle E. Yohe, Benjamin Z. Stanton, Bruno Amadio, Ignazio Caruana, Cristiano De Stefanis, Rita De Vito, Franco Locatelli, Yidong Chen, Eleanor Y. Chen, Peter Houghton, Javed Khan, Rossella Rota & Myron S. […]

Nature Communications: Integrated analysis of telomerase enzymatic activity unravels an association with cancer stemness and proliferation (Zheng Lab)

January 12, 2021

          Nighat Noureen, Shaofang Wu, Yingli Lv, Juechen Yang, W. K. Alfred Yung, Jonathan Gelfond, Xiaojing Wang, Dimpy Koul, Andrew Ludlow & Siyuan Zheng Abstract Active telomerase is essential for stem cells and most cancers to maintain telomeres. The enzymatic activity of telomerase is related but not equivalent to the expression of TERT, the catalytic subunit of the complex. Here […]