Greehey CCRI Seminar Series: Richard Gregory, PhD, (Harvard Medical School)

Event Date & Time

December 6, 2024

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About the Speaker(s)

The Gregory lab aims to discover pathways of RNA regulation for the development of new therapies for cancer and other diseases.
Our research is focused on identifying and characterizing new mechanisms of RNA regulation in the dynamic control of gene expression. We apply this knowledge to explore how RNA regulatory pathways impact stem cell pluripotency, mammalian development, growth, cancer, and neurological diseases. Ultimately we aim to exploit this understanding for the development of new therapeutic approaches for cancer and degenerative disease.

RNA interference (RNAi) describes the recently identified phenomenon whereby small non-coding RNAs can silence gene expression. It is emerging that cells possess a wide repertoire of tiny regulatory RNAs that are critical for a variety of biological pathways and can repress genes via numerous mechanisms. For posttranscriptional gene silencing, microRNAs (miRNAs) and small inhibitory RNAs (siRNAs) function as guide molecules inducing mRNA degradation or translational repression.

Learn more about Dr. Gregory's research:  hsci.harvard.edu/people/richard-i-gregory-phd

 

Hosted by:Yogesh K. Gupta, M. Tech, PhD