Greehey CCRI ZOOMinar Series Presents: Patrick Sung, PhD – UT Health, San Antonio
Event Date & TimeJanuary 29, 2021 at 11:00 am - 12 noon
LocationZoom Meeting ID: 977 8043 2270, Passcode: 86mwx7
Presentation Title: “Role of the Tumor Suppressor BRCA2 in Chromosome Damage Repair”:
Greehey CCRI Faculty Host: Raushan Kurmasheva, PhD.
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About the Speaker(s)
Patrick Sung, PhD
Biochemistry and structural biology
Endogenous free radicals and environmental agents such as ionizing radiation induce DNA double-strand breaks. The repair of these breaks is crucial for the maintenance of genome stability. Two distinct pathways help eliminate DNA double-strand breaks. In homologous recombination (HR), the repair of a broken DNA molecule requires an intact homologous duplex to direct the process. Alternatively, a pathway known as non-homologous DNA end joining (NHEJ) simply rejoins the ends of the broken DNA molecule. Our research efforts focus on delineating the mechanism of homology-directed repair of DNA double-strand breaks in the yeast Saccharomyces cerevisiae and in humans, with special emphasis being placed on the roles of the breast and ovarian tumor suppressors BRCA1 and BRCA2 in the repair process.
Related diseases: Breast cancer, ovarian cancer, childhood cancers
Techniques: Protein purification, nucleic acid biochemistry, enzymology, cell biology, single-molecule biophysics, structural biology including cryoEM, EM, AFM, SAXS, NMR, and X-ray crystallography