Greehey CCRI Seminar Series ’20: Patrick Sung, DPhil
Event Date & TimeFebruary 21, 2020
LocationGreehey CCRI Auditorium, 2.160
Talk title and subject TBA
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About the Speaker(s)
Interim Chair, Robert A. Welch Distinguished Chair in Chemistry
and Associate Dean for Research, LSOM
Greehey CCRI Host: Raushan Kurmasheva, Ph.D.
About Dr. Sung's Research:
Endogenous free radicals and environmental agents such as ionizing radiation induce DNA double-strand breaks. The repair of these breaks is crucial for the maintenance of genome stability. Two distinct pathways help eliminate DNA double-strand breaks. In homologous recombination (HR), the repair of a broken DNA molecule requires an intact homologous duplex to direct the process. Alternatively, a pathway known as non-homologous DNA ends joining (NHEJ) simply rejoins the ends of the broken DNA molecule. Our research efforts focus on delineating the mechanism of homology-directed repair of DNA double-strand breaks in the yeast Saccharomyces cerevisiae and in humans, with special emphasis being placed on the roles of the breast and ovarian tumor suppressors BRCA1 and BRCA2 in the repair process.