Greehey CCRI Seminar Series ’20: Patrick Sung, DPhil

Event Date & Time

February 21, 2020

Location

Greehey CCRI Auditorium, 2.160


Event Details:

Talk title and subject TBA

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About the Speaker(s)

Patrick Sung, DPhil Interim Chair, Robert A. Welch Distinguished Chair in Chemistry and Associate Dean for Research, LSOMPatrick Sung, DPhil, UT Health San Antonio

Interim Chair, Robert A. Welch Distinguished Chair in Chemistry
and Associate Dean for Research, LSOM

Greehey CCRI Host: Raushan Kurmasheva, Ph.D.

About Dr. Sung's Research:
Endogenous free radicals and environmental agents such as ionizing radiation induce DNA double-strand breaks. The repair of these breaks is crucial for the maintenance of genome stability. Two distinct pathways help eliminate DNA double-strand breaks. In homologous recombination (HR), the repair of a broken DNA molecule requires an intact homologous duplex to direct the process. Alternatively, a pathway known as non-homologous DNA ends joining (NHEJ) simply rejoins the ends of the broken DNA molecule. Our research efforts focus on delineating the mechanism of homology-directed repair of DNA double-strand breaks in the yeast Saccharomyces cerevisiae and in humans, with special emphasis being placed on the roles of the breast and ovarian tumor suppressors BRCA1 and BRCA2 in the repair process.