Greehey CCRI Seminar Series: Edward Seto, PhD – George Washington (in-person)
Event Date & TimeSeptember 2, 2022 at 12 noon CT
Presentation Title: Targeting HDACs for Cancer Therapy and Beyond.
Greehey CCRI Host:Katsumi Kitagawa, Pharm.D., PhD
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About the Speaker(s)
The Seto Lab has a long-standing interest in gene regulation and histone deacetylases (HDACs). We discovered and cloned HDAC2 and HDAC3 enzymes and performed detailed analyses of these proteins early on. Over the last 25 years, we have been actively studying many different aspects of histone deacetylation, including the dissection of all 18 human HDACs. Our work has led to seminal discoveries regarding the regulation of histone deacetylation and the identification of key non-histone targets of the HDAC enzymes. More recently, our work has extended to the analysis of how the activities/functions of histone acetyltransferases (HATs) and HDACs are interrelated, elucidating the role of HDACs in anti-tumor immunity, and identifying HDAC-specific inhibitors for disease treatments.