Greehey CCRI Seminar Series, Spring ’23: Roger Greenberg, M.D., Ph.D. – Penn University

Roger Greenberg, MD, PhD, is the J. Samuel Staub, M.D. Professor in the Department of Cancer Biology at the University of Pennsylvania Perelman School of Medicine, where he also serves as Director of the Penn Center for Genome Integrity and the Director of Basic Science for the Basser Center for BRCA. During Dr. Greenberg’s early training, he demonstrated the first evidence that telomere shortening suppresses carcinogenesis in vivo, and subsequently, he helped define a BRCA1-centered tumor suppressor network. Dr. Greenberg’s independent laboratory investigates basic mechanisms of genome integrity maintenance and their impact on cancer etiology and response to therapy. His group discovered that ubiquitin chains serve as a platform for BRCA1 DNA damage recognition, identified biallelic mutations in BRCA1 as a cause of Fanconi Anemia, and developed novel systems to identify ATM kinase-dependent transcriptional silencing near DNA double-strand breaks. More recently, his group defined the molecular underpinnings of homologous recombination-dependent telomere lengthening mechanisms that occur in nearly 15% of cancers and mechanisms that enable DNA damage responses to communicate with the immune system.

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