Online Seminar Series: Muller Fabbri, MD, PhD (Univ of Hawaii)
Event Date & TimeSeptember 4, 2020 at 11:00 am CDT
LocationZoom Meeting ID: TBA
Join Greehey CCRI online as we welcome Muller Fabbri, MD, Ph.D., Program Co-Leader, Cancer Biology Program, Full Member - Cancer Biology Program, University of Hawaiʻi Cancer Center
Dr. Fabbri's presentation will be conducted virtually, Zoom meeting info to follow.
Presentation Title: TBA
Zoom Meeting ID: TBA
Greehey CCRI Host: Alexander Pertsemlidis, Ph.D.
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About the Speaker(s)
My research focuses on the role of microRNAs (and other non-coding RNAs) in the biology of cancer. Non-coding RNAs have been shown to be involved in all aspects of cancer biology. My lab focuses on how microRNAs and long non-coding RNAs mediate intercellular communication within the Tumor Microenvironment (TME). Specifically, we have pioneered the idea that microRNAs can function as ligands of receptors and have shown that cancer cells can release microRNAs within extracellular vesicles able to deliver them to surrounding Tumor-Associated Macrophages (TAMs). Cancer-derived vesicular microRNAs can bind to Toll-like receptor 8 (TLR8) in TAMs triggering downstream NF-κB signaling and the secretion of cytokines and other vesicular microRNAs that promote cancer cell growth, dissemination and the development of drug resistance. Currently, my laboratory is interested in developing effective methods to interrupt this aberrant cross-talk between cancer cells and surrounding cells of the TME, in order to prevent/overcome drug resistance. Another interest of my lab is to investigate the role of exosomes (and other extracellular vesicles) in modulating the immune response against cancer cells and to assess their implications as biomarkers for liquid biopsies conducive to early cancer detection, prognosis, and prediction of response therapy. Finally, we are interested in defining the mechanism of action of transcribed ultraconserved regions and other long non-coding RNAs and assess their function and role in cancer biology and resistance to therapy, with the ultimate goal to identify new molecular targets for cancer treatment.