Greehey CCRI Seminar Series: Qing Richard Lu, PhD (Distinguished) Cincinnati Children’s Hospital
Event Date & Time
March 11, 2022 at 11:00 AM CSTLocation
https://zoom.us/j/91409021393?pwd=YzloQnFvalFtVXE4T0YybWMxZEZsQT09Event Details:
Presentation Title: “Targeting of Tumor Heterogeneity and Plasticity for Brain Cancer Therapy”
Greehey CCRI Hosts
Yidong Chen, PhD
Siyuan Zheng, PhD
About the Speaker(s)
Professor, UC Department of Pediatrics
Glial cell biology, myelination, and brain/nerve tumor biology
Research in Lu Lab aims to understand how distinct glial cell subtypes (oligodendrocytes, astrocytes, and Schwann cells) in the central and peripheral nervous systems are generated, how they are regenerated after injury, and how their progenitors are transformed into cancerous cells under pathological conditions. We study the development and regeneration of glial progenitors using a variety of novel molecular, cellular, and imaging technologies in combination with in vivo targeting and fate mapping approaches. A major focus of our lab research is to elucidate the transcriptional, posttranscriptional, epigenetic, and signaling regulatory networks that govern glial progenitor fate specification, myelination, and glioma formation. We have established a series of animal models for demyelinating neurodegenerative diseases such as multiple sclerosis, developmental neurological disorders such as CHARGE syndrome, MOWAT-WILSON syndrome, and autisms, as well as brain tumor animal models and patients-derived xenograft models. Our research goal is to dissect the etiological mechanisms of these neurological diseases and develop effective therapies through promoting myelin repair, nerve regeneration, or functional recovery in various neurological diseases while blocking brain tumor initiation and progression.