Greehey CCRI Seminar Series: Richard White, MD, PhD, Memorial Sloan Kettering Cancer Center

We are interested in the ways in which developmental programs affect cancer progression, and how these programs are altered by the microenvironment. To address these questions, we primarily utilize the zebrafish as a model, given its strengths in genetic manipulation and imaging, which is enhanced in our previously developed transparent casper strain of fish. We additionally use human pluripotent stem cell models of cancer to complement what can be done in vivo in the fish. With state-of-the-art genetic engineering and high-resolution imaging, our goal is to dissect these interactions to understand how tumors start and eventually metastasize to new locations.

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