Greehey CCRI News & Events Archive

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iScience: PEGylated talazoparib enhances therapeutic window of its combination with temozolomide in Ewing sarcoma (Kurmasheva & Houghton Labs)

January 18, 2022

Vanessa del Pozo Andrew J.Robles Shaun D.Fontaine QianqianLiu Joel E.Michalek Peter J.Houghton Raushan T.Kurmasheva Highlights Nanoparticle-formulated drugs minimize drug-induced toxicity PEG∼TLZ enhances in vivo activity of TMZ in pediatric tumor xeno …

Cellular Oncology: Single-cell RNA profiling identifies diverse cellular responses to EWSR1/FLI1 down regulation in Ewing sarcoma cells (Houghton, Chen, Kitagawa, Ignatius)

January 12, 2022

Roxane Khoogar, Fuyang Li, Yidong Chen, Myron Ignatius, Elizabeth R. Lawlor, Katsumi Kitagawa, Tim H.-M. Huang, Doris A. Phelps & Peter J. Houghton Background The EWSR1/FLI1 gene fusion is the most common rearrangement leading to cell transformatio …

Genes & Cancer: EZH2 suppresses endogenous retroviruses and an interferon response in cancers (Shiio Lab)

January 10, 2022

Panneerselvam Jayabal1, Xiuye Ma1 and Yuzuru Shiio1,2,3 ABSTRACT Ewing sarcoma is an aggressive cancer of the bone and soft tissue in children. It is characterized by the chromosomal translocation between EWS and an Ets family transcription factor, mos …

PMC: The Role of Hedgehog Pathway in Uterine Leiomyosarcoma (Houghton Lab)

January 7, 2022

Natalia Garcia,1 Mara Ulin,2 Ayman Al-Hendy,3 and Qiwei Yang3 DESCRIPTION The uterine Leiomyosarcoma (LMS) represents 3%-7% of all uterine cancers. This rare tumor has an annual incidence of 0.8 per 100,00 women. Unfortunately, LMS is well known for it …

MDPI: Altertoxin II, a Highly Effective and Specific Compound against Ewing Sarcoma (Houghton Lab)

January 6, 2022

Andrew J. Robles Wentao Dai Saikat Haldar Hongyan Ma Victoria M. Anderson Ross D. Overacker April L. Risinger, Sandra Loesgen Peter J. Houghton Robert H. Cichewicz Susan L. Mooberry Simple Summary Ewing sarcoma is a cancer of the bone and soft tissues …

ASM Journals: GRWD1-WDR5-MLL2 Epigenetic Complex Mediates H3K4me3 Mark and Is Essential for Kaposi’s Sarcoma-Associated Herpesvirus-Induced Cellular Transformation (Lai)

January 5, 2022

Shan Wei, Songjian Lu, Lifan Liang, Xian Wang, Wan Li, Tingting Li, Luping Chen, , Enguo Ju, Xinquan Zhang, Zhao Lai, Yufei Huang, Xinghua Lu, Shou-Jiang Gao  ABSTRACT Infection by Kaposi’s sarcoma-associated herpesvirus (KSHV) is causally associated w …

Briefings in Bioinformatics: Deep learning tackles single-cell analysis—a survey of deep learning for scRNA-seq analysis (Chen Lab)

January 4, 2022

        Mario Flores, Zhentao Liu, Tinghe Zhang, Md Musaddaqui Hasib, Yu-Chiao Chiu, Zhenqing Ye, Karla Paniagua, Sumin Jo, Jianqiu Zhang, Shou-Jiang Gao, Yu-Fang Jin, Yidong Chen, Yufei Huang Abstract Since its selection as the met …

MDPI: The RNA-Binding Protein Musashi1 Regulates a Network of Cell Cycle Genes in Group 4 Medulloblastoma (Penalva Lab)

December 25, 2021

by  Mirella Baroni 1 , Gabriela D. A. Guardia 2 , Xiufen Lei 1, Adam Kosti 1,3, Mei Qiao 1, Tesha Landry 1, Karl Mau 1, Pedro A. F. Galante 2  and Luiz O. F. Penalva Abstract Medulloblastoma is the most common malignant brain tumor in children. Treatme …

Journal of Clinical & Translational Science: Examining access to care in clinical genomic research and medicine: Experiences from the CSER Consortium (Tomlinson)

December 13, 2021

Amanda M. Gutierrez Jill O. Robinson, Simon M. Outram, Hadley S. Smith, Stephanie A. Kraft, Katherine E. Donohue, Barbara B. Biesecker, Kyle B. Brothers, Flavia Chen, Benyam Hailu, Lucia A. Hindorff, Hannah Hoban, Rebecca L. Hsu, Sara J. Knight, Barbar …

CANCER RESEARCH: SNAI2-Mediated Repression of BIM Protects Rhabdomyosarcoma from Ionizing Radiation (Houghton, Ignatius, Vaseva, and Zheng labs)

November 24, 2021

Long Wang, Nicole R. Hensch, Kathryn Bondra, Prethish Sreenivas, Xiang R. Zhao, Jiangfei Chen, Rodrigo Moreno Campos, Kunal Baxi, Angelina V. Vaseva, Benjamin D. Sunkel, Berkley E. Gryder, Silvia Pomella, Benjamin Z. Stanton, Siyuan Zheng, Eleanor Y. C …

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