NPJ – Precision Oncology: Benchmarking mouse contamination removing protocols in patient-derived xenografts genomic profiling (Zheng, Wang, Kurmasheva, Houghton, Lai, & Chen Labs)
April 17, 2025Mukund Bhandari, Funan He, Anna Rogojina, Fuyang Li, Yi Zou, Jing Jiang, Zhao Lai, Peter Houghton, Raushan T. Kurmasheva, Yidong Chen, Xiaojing Wang & Siyuan Zheng Abstract Patient-derived xenograft (PDX) models are widely used in cancer research. …
Clinical Cancer Research: Update on Cancer and Central Nervous System Tumor Surveillance in Pediatric NF2-, SMARCB1-, and LZTR1-Related Schwannomatosis (Tomlinson)
April 15, 2025Melissa R. Perrino Marjolijn C.J. Jongmans Gail E. Tomlinson Mary-Louise C. Greer Sarah R. Scollon Sarah G. Mitchell Jordan R. Hansford Kris Ann P. Schultz Wendy K. Kohlmann Jennifer M. Kalish Suzanne P. MacFarland Anirban Das Kara N. Maxwell Stefan M. …
IScience: Dissection of tumoral niches using spatial transcriptomics and deep learning (Chen)
April 15, 2025Karla Paniagua1 ∙ Yu-Fang Jin1 ∙ Yidong Chen2,3 ∙ Shou-Jiang Gao4,5 ∙ Yufei Huang4,6,7 ∙ Mario Flores1,8 mario.flores@utsa.edu Highlights •TG-ME integrates transformer and GraphVAE for cancer niche analysis •Achieves superior clustering and profiling t …
Structure: Structural insights into the assembly and regulation of 2′-O RNA methylation by SARS-CoV-2 nsp16/nsp10 (Gupta Lab)
April 14, 2025Anurag Misra 1 2, R. Rahisuddin 1 2, Manish Parihar 1, Shailee Arya 1, Thiruselvam Viswanathan 1 2, Nathaniel Jackson 3, Shan Qi 1 2, Siu-Hong Chan 4, Reuben S. Harris 2 5, Luis Martinez-Sobrido 3, Yogesh K. Gupta 1 2 6 Highlights SARS-CoV-2 nsp16/nsp1 …
Molecular Oncology: Hijacking the BAF complex: the mechanistic interplay of ARID1A and EWS::FLI1 in Ewing sarcoma (Libich Lab)
April 10, 2025Erich J. Sohn, David S. Libich Abstract Ewing sarcoma, an aggressive pediatric cancer, is driven by the EWS::FLI1 fusion protein, which disrupts gene expression by hijacking the BAF chromatin remodeling complex. Central to this mechanism is the formati …
Biomolecular NMR Assignments: The 1H, 15N and 13C backbone resonance assignments of the N-terminal (1-149) domain of Serpine mRNA Binding Protein 1 (SERBP1) (Libich Lab)
March 31, 2025Antoine Baudin1, Hoang H Dinh1, Xiaoping Xu1, David S Libich2 Abstract Serpine mRNA-Binding Protein 1 (SERBP1) is an RNA-binding protein implicated in diverse cellular functions, including translational regulation, tumor progression, and stress respons …
Int’l Journal of Molecular Sciences: The Role of the Tumor Microenvironment (TME) in Advancing Cancer Therapies: Immune System Interactions, Tumor-Infiltrating Lymphocytes (TILs), and the Role of Exosomes and Inflammasomes (Aune Lab)
March 28, 2025by, Atef M. Erasha Hanem EL-Gendy Ahmed S. Aly Marisol Fernández-Ortiz Ramy K. A. Sayed Abstract Understanding how different contributors within the tumor microenvironment (TME) function and communicate is essential for effective cancer detection and …
Progress in Neurobiology: Pathogenic Oligomeric Tau alters Neuronal RNA Processes through the Formation of Nuclear Heteromeric Amyloids with RNA-Binding Protein Musashi1 (Penalva)
March 11, 2025Nicha Puangmalai a b 1, Abbigael E. Aday a b 1, Madison Samples a b, Nemil Bhatt a b, Filippa Lo Cascio a b, Michela Marcatti a b, Suhyeorn J. Park a b, Leiana Fung a b, Cynthia Jerez a b, Luiz O. Penalva c d, Yingxin Zhao e, Haiping Hao f, Doreen Luga …
ELife: SERBP1 interacts with PARP1 and is present in PARylation-dependent protein complexes regulating splicing, cell division, and ribosome biogenesis (Libich, Penalva, et al)
February 13, 2025Kira Breunig#1, Xuifen Lei#1, Mauro Montalbano#23, Gabriela D A Guardia4, Shiva Ostadrahimi15, Victoria Alers156, Adam Kosti15, Jennifer Chiou7, Nicole Klein1, Corina Vinarov1, Lily Wang1, Mujia Li1, Weidan Song8, W Lee Kraus8, David S Libich16, Stefan …
ELife: Structure of METTL3-METTL14 with an m6A nucleotide reveals insights into m6A conversion and sensing (Rao, Gupta, et al)
February 11, 2025Abstract The nuclear METTL3-METTL14 transfers a methyl group from SAM to convert the N6 of adenosine (A) in RNA to m6A and in ssDNA to 6mA. m6A marks are prevalent in eukaryotic mRNAs and lncRNAs and modulate their stability and fate in a context-depen …
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