Clinical Cancer Research: Preclinical Activity of the B7-H3-Targeting Antibody Drug Conjugate (ADC) Vobramitamab Duocarmazine (Vobra Duo) in Pediatric Cancer Solid Tumors (Chen, Houghton, Kurmasheva Lab)
April 22, 2026Edward Favours Haiying Tang Peyton Wong Samuel Ghilu Vanessa del Pozo Elena Mironova Yidong Chen Tim Stearns Steven Neuhauser Eric J. Earley Stephen W. Erickson Jee Young Kwon Emily L. Jocoy David Groff Kateryna Krytska Matthew Tsang Be …
Journal of Biological Chemistry: Structural Basis for the Mechanism and Stability of the EEPD1 5’ Endonuclease (Gupta Lab)
April 10, 2026Robert A. Hromas1,∗ guptay@uthscsa.edu ∙ Aruna S. Jaiswal1,∗ ∙ Anurag Misra2,∗ ∙ Yaxia Yuan3 ∙ Daohong Zhou3 ∙ John I. Beckman2 ∙ Shailee Arya2 ∙ Adhishree Chidambaram2 ∙ Alexander B. Taylor2 ∙ Wendell Griffith4 ∙ Arunima Jaiswal1 ∙ Elizabeth A. Willia …
Nature Structural & Molecular Biology: Resolution of R-loops and transcription–replication conflicts by SETX–BRCA1–BARD1 complex (Sung Lab, Rao Lab)
April 1, 2026Abstract Senataxin (SETX), an RNA–DNA helicase, accumulates at transcription pause sites through the tumor suppressor BRCA1. Here, we provide mechanistic insight into how SETX–BRCA1 resolves transcription-associated R-loops to prevent deleterious outco …
Cancers: Biological Advances and Current Challenges for Pediatric Rhabdomyosarcoma (Houghton, Ignatius, et al)
March 30, 2026by Katie E. Hebron, Patience Odeniyide, Yun Wei, Berkley E. Gryder, G. Barr, Dana L. Casey, Eleanor Y. Chen, Brian D. Crompton, Filemon S. Dela Cruz, Adam D. Durbin, Heide L. Ford, Susanne A. Gatz, Mark E. Hatley, Anton G. Henssen, Simone Hettmer, Pete …
BioRxiv: Diverse Mechanisms of SMARCB1 Inactivation and Genome Maintenance Defects in Ultra-Rare Malignant Rhabdoid Tumors (Kurmasheva Lab, Chen, Lai)
March 27, 2026Elizabeth Rasmussen, Elena Mironova, Zhao Lai, Kendra Maaß, Stefanie Volz, Dias Kurmashev, Stefan M. Pfister, Yidong Chen, Raushan T. Kurmasheva ABSTRACT Malignant rhabdoid tumors (MRTs) are extremely rare and highly aggressive pediatric cancers classi …
BioRxiv: Intrinsically disordered SERBP1 regulates translation through topology-driven G-quadruplex recognition (Libich Lab)
March 19, 2026Antoine Baudin, Hoang H. Dinh, Kira Breunig, Xuifen Lei, Xiaoping Xu, View Luiz O. Penalva, David S. Libich Abstract Serpine mRNA-binding protein 1 (SERBP1) is an intrinsically disordered RNA-binding protein that regulates translat …
iScience: Predicting and interpreting protein and phosphoprotein abundance from pan-cancer and single-cell transcriptomes (Chen Lab)
March 12, 2026Hui-Mei Tsai1,2,3,12 ∙ Tzu-Hung Hsiao2,4,5,12 ∙ Yu-Chiao Chiu6,7 ∙ Yufei Huang6,7 ∙ Eric Y. Chuang1,8,9,10 chuangey@ntu.edu.tw ∙ Yidong Chen3,11,13 cheny8@uthscsa.edu Highlights • DeepGxP provides a framework to translate transcriptomes into proteomic …
Chemical Science: Unveiling BCL-xL-specific PROTAC efficiency and dissociation pathways using native mass spectrometry (Olsen, Zhou)
February 24, 2026Mohamed I. Gadallah, Kailyn L. Nonhof, Digant Nayak, Peiyi Zhang, Olivia Dioli, Guangrong Zheng, Shaun K. Olsen, Daohong Zhou and Jennifer S. Brodbelt Author affiliations Abstract Overexpression of anti-apoptotic proteins such as BCL-xL …
Haematologica: IGF2BP3 inhibition: another home run for RNA-binding protein targeting in hematological malignancies (Penalva)
February 10, 2026Luiz O.F. Penalva RNA-binding proteins (RBPs) are critical regulators of gene expression, aNecting RNA processing till translation. More than 1,500 proteins have been catalogued as RBPs in the human genome. 1 RBPs are very diverse in respect to structu …
BioRxiv: High-throughput mapping of 6,888 RAD51D variants identifies distinct biochemical functions needed for homologous recombination and olaparib response (Sung)
January 30, 2026Kristie E. Darrah, Shelby L. Hemker, Yashpal Rawal, Noah J. Goff, Phoebe Parker, Gayatri Ganesan, Caleb M. Stratton, Katherine Oppenheimer, Ella Roberts, Elena Glick, Nicole Banks, Arjun Kumar, Silvia Casadei, Matthew W. Snyder, Katherine Nathanson, Su …
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