Nucleic Acids Research: Researchers Find a New Weak Spot in Cancer’s DNA Repair System (Olsen, Zhou, Sung Lab, Hromas)
September 1, 2026Every time a cell divides, it has to copy billions of pieces of DNA. It is an incredibly complicated process, and mistakes or damage are inevitable. Healthy cells have several ways to fix those problems before they become dangerous. Cancer cells do, to …
Cell Reports: EWSR1::FLI1 promotes neocentromere formation in Ewing sarcoma cells (Zheng, Sung Lab, Kitagawa Lab)
August 17, 2026Risa Kitagawa1,2 ∙ Ediri E. Metitiri1,2 ∙ Bin Yu1,2 ∙ Changxian Shen1,2,6 ∙ Alexander J.R. Bishop1,3,5 ∙ Siyuan Zheng1,4 ∙ Peter J. Houghton1,2 ∙ Katsumi Kitagawa1,2,7 Send email to kitagawak@uthscsa.edu Highlights Summary Ewing sarcoma (EwS) is charac …
Nature Communications: HELZ-BRCA2 complex resolves R-loops to drive transcription-coupled homologous recombination (Wasmuth, Zheng, Sung Lab, Zhao)
August 12, 2026Wenjing Li, Bo Wu, Boya Gao, Elizabeth M. Irvin, Arijit Ghosh, Lillian Eliaz, Yuxin Huang, Youngho Kwon, Clara M. Stiefel, Tram Thi Ngoc Nguyen, David Zhao, Humberto Javier Suarez, Tengyang Ni, Salvador Alejo, O’Taveon Fitzgerald, Xuemei Song, Sandip K …
International Journal of Molecular Sciences: Biogenic Metal Nanoparticles from Indian Flora as Programmable Bio-Interfaces: From Phytochemical Coronas to Precision Nanomedicine (Wasmuth Lab)
August 3, 2026Sharad Shriram Tat Kailas D. Datkhile Jayant R. Pawar Amar R. Mohite Tanisha Sharma Abstract Biogenic metal nanoparticles are naturally covered with the phytochemical corona, which includes plant-derived metabolites. Emerging evidence suggests that the …
Function: Constitutive mTORC1 Activation in Skeletal Muscle Increases Inflammation but is not Sufficient to Impair Glucose Tolerance (Lai Lab)
July 23, 2026Erik D. Marchant, Hanna Kalenta, Sean P. Kilroe, Jacquelyn May, Wenjun Z. Martini, Korri S. Weldon, Zhao Lai, and Blake B. Rasmussen Abstract Aberrant mechanistic target of rapamycin complex 1 (mTORC1) signaling in skeletal muscle has been implicated …
Nature Communications: Multifaceted roles of PDS5B in RAD51-dependent homology-directed DNA repair and replication fork protection (Sung Lab, Libich, Olsen, Wasmuth, Rao, et al)
July 22, 2026Jeffrey N. Katz, Lorena Samentar, Qingming Fang, Jae-Hoon Ji, Wenjing Li, Qiongmei Gao, Sahiti Kuppa, Boya Gao, Cody M. Rogers, Hardeep Kaur, Aida Badamchi Shabestari, Arijit Dutta, Shahrez Syed, Miriam Tovar, Nozomi Tomimatsu, Bipasha Mukherjee, Eliza …
Nature Structural & Molecular Biology: CST complex promotes second-strand synthesis in break-induced replication (Sung Lab, Malkova, et al)
July 21, 2026Pilendra Thakre, Jeff Wang, Liping Liu, Sameer Shah, Zhenxin Yan, Nhung Pham, Meng-Chia Tsai, Yuqin Zhao, Cody M. Rogers, Zhitong Feng, Hengyao Niu, Youngho Kwon, Xiaohua Wu, Anna Malkova, Patrick Sung & Grzegorz Ira Abstract Break-induced DNA repl …
Nature Communications: Break-induced replication forms long mutable single-strand DNA during meiosis (Malkova)
June 22, 2026Thanks to advances in treatment, more than 85% of children diagnosed with cancer now survive into adulthood. However, many survivors face long-term health challenges caused by their cancer treatments, including heart disease, diabetes, high blood press …
mBio: Identification and characterization of a SARS-CoV-2 Mpro G23 deletion ensitrelvir-resistant mutant (Gupta Lab)
June 8, 2026Yao Ma, R. Rahisuddin, Sara H. Mahmoud, Anastasija Cupic, Ahmed Magdy Khalil, Esteban Castro, Nathaniel Jackson, Mahmoud Bayoumi, Shailee Arya, Yogesh K. Gupta, Adolfo García-Sastre , Richard K. Plemper, Luis Martinez-Sobrido ABSTRACT Ensitrelvir is an …
Nature Structural & Molecular Biology: Structural insight into how RAD51 paralog exchange regulates RAD51 filament formation (Sung Lab, Hromas, Zhou, Zhao, Wasmuth, Olsen)
June 5, 2026Yashpal Rawal, Youngho Kwon, Lijia Jia, Eliza A. Ruben, Jae-Hoon Ji, Lijuan Guo, Caleb M. Stratton, Digant Nayak, Miriam Tovar, Qingming Fang, Mohd Azrin Jamalruddin, Shuo Zhou, Sahiti Kuppa, Shahrez Syed, Angela M. Jasper, Jeffrey N. Katz, Cody M. Rog …
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