Greehey CCRI Archives
MedicalXpress – One Mouse at a Time: a New Approach to Testing Potential Drugs for Children’s Cancers (Houghton, Kurmasheva, PPTC)
October 22, 2020by European Organisation for Research and Treatment of Cancer A team of researchers in the US and Australia have developed a way of testing potential drugs for children’s cancers so as to take account of the wide genetic diversity of these diseases. In …
Stand Up to Cancer: Alexander J. R. Bishop, DPhil to Lead One of Three Trans-Atlantic Teams to Study Hard-to-Treat Childhood Cancers
October 20, 2020Published On: October 19, 2020 Shared by Rosanne Fohn SAN ANTONIO (Oct. 19, 2020) — Although COVID-19 has become the top health and research priority around the world, a child is still diagnosed with cancer every two minutes globally. To meet this urge …
Pediatric Blood & Cancer: Radiation therapy and molecular‐targeted agents in preclinical testing for immunotherapy, brain tumors, and sarcomas: Opportunities and challenges (Houghton)
October 14, 2020Radiation therapy and molecular‐targeted agents in preclinical testing for immunotherapy, brain tumors, and sarcomas: Opportunities and challenges Ralph Vatner, Charles D. James, Vythialingam Sathiaseelan, Kathryn M. Bondra, John A. Kalapurakal, Peter …
Breast Cancer Research and Treatment: KDM1A inhibition is effective in reducing stemness and treating triple negative breast cancer
October 14, 2020Abstract Purpose Cancer stem cells (CSCs) are highly tumorigenic, spared by chemotherapy, sustain tumor growth, and are implicated in tumor recurrence after conventional therapies in triple-negative breast cancer (TNBC). Lysine-specific histone demethy …
Pipette Gazette: Trevi Mancilla First Author Publication in PLOS One About The Significance Of Non-Cardiomyocyte Cells (Aune Lab)
September 30, 2020Trevi Mancilla, a student in the South Texas Medical Scientist Training Program, has published a first-author publication in PLOS ONE. The title is “Doxorubicin-induced p53 interferes with mitophagy in cardiac fibroblasts.” Her mentor is Dr. Greg Aune. …
Cardiovascular Business: Chemotherapy could be damaging children’s heart cells, leading to problems later in life (Aune)
September 30, 2020Undergoing chemotherapy can have a negative impact on the cells responsible for repairing heart damage, according to a new study published in PLOS One. This may explain why 20% of children treated with anthracyclines go on to experience heart failure l …
Medical Xpress: Childhood Chemo Alters Heart’s Caretaker Cells, Study Finds (Aune Lab)
September 30, 2020by Will Sansom, UT Health San Antonio Cancer chemotherapy changes the function of cells that repair heart injury, researchers at The University of Texas Health Science Center at San Antonio (UT Health San Antonio) discovered. Twenty percent of children …
Scientific Reports: “Transcriptomic Sex Differences in Sensory Neuronal Populations of Mice”
September 23, 2020Jennifer Mecklenburg 1, Yi Zou 2, Andi Wangzhou 3, Dawn Garcia 2, Zhao Lai 2 4, Alexei V Tumanov 5, Gregory Dussor 3, Theodore J Price 3, Armen N Akopian 6 7 Abstract Many chronic pain conditions show sex differences in their epidemiology. This could b …
PLOS One: Doxorubicin-induced p53 interferes with mitophagy in cardiac fibroblasts (Aune)
September 22, 2020T. R. Mancilla, L. R. Davis, G. J. Aune Abstract Anthracyclines are the critical component in a majority of pediatric chemotherapy regimens due to their broad anticancer efficacy. Unfortunately, the vast majority of long-term childhood cancer survivor …
Scientific Reports: Transcriptomic sex differences in sensory neuronal populations of mice
September 17, 2020Jennifer Mecklenburg 1, Yi Zou 2, Andi Wangzhou 3, Dawn Garcia 2, Zhao Lai 2 4, Alexei V Tumanov 5, Gregory Dussor 3, Theodore J Price 3, Armen N Akopian 6 7 Abstract Many chronic pain conditions show sex differences in their epidemiology. This could b …