Greehey CCRI Archives

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Advanced Photon Source: How SARS-CoV-2 RNA Evades Host Immune Responses (Gupta Lab)

August 26, 2020

As we all know too well, the virus SARS-CoV-2 causes severe respiratory illness COVID-19. In parallel with the critical search for a cure, scientists are working diligently to develop effective treatments that can help lower the morbidity of this deadl …


Luiz O.F. Penalva PhD Awarded CPRIT Grant to Study New Glioblastoma (GBM) Regulator

August 20, 2020

PROJECT SUMMARY Glioblastoma (GBM) is the most common and most aggressive brain tumor type among adults with a 14 months average patient survival. Despite all genomic efforts in recent years, novel therapies based on GBM common mutations and alteration …


Genome Biology: The RNA-binding protein SERBP1 functions as a novel oncogenic factor in glioblastoma by bridging cancer metabolism and epigenetic regulation.

August 20, 2020

Background RNA-binding proteins (RBPs) function as master regulators of gene expression. Alterations in RBP expression and function are often observed in cancer and influence critical pathways implicated in tumor initiation and growth. Identification a …


Alexander Pertsemlidis, PhD Co-Awarded National Science Foundation Grant.

August 20, 2020

PI: Leonidas Bleris, PhD                       Co-PI: Alexander Pertsemlidis, PhD (UT Dallas)                                              (UT Health San Antonio) PROJECT SUMMARY Collaborative Research: Unraveling extracellular microRNA communication O …


Luiz O.F. Penalva PhD Awarded CPRIT Grant to Study Glioblastoma (GBM)

August 20, 2020

PROJECT SUMMARY Glioblastoma (GBM) is the most common and most aggressive brain tumor type among adults with a 14 months average patient survival. Despite all genomic efforts in recent years, novel therapies based on GBM common mutations and alteration …


Cellular and Molecular Bioengineering: Scaffold Architecture and Matrix Strain Modulate Mesenchymal Cell and Microvascular Growth and Development in a Time Dependent Manner

August 18, 2020

2020 CMBE Young Innovators issue Gennifer Chiou, Elysa Jui, Allison C. Rhea, Aparna Gorthi, Solaleh Miar, Francisca M. Acosta, Cynthia Perez, Yasir Suhail, Kshitiz, Yidong Chen, Joo L. Ong, Rena Bizios, Christopher Rathbone & Teja Guda Abstract Bac …


Genome Biology: The RNA-binding protein SERBP1 functions as a novel oncogenic factor in glioblastoma by bridging cancer metabolism and epigenetic regulation (Bishop & Penalva Labs)

August 6, 2020

Adam Kosti 1 2, Patricia Rosa de Araujo 1 2, Wei-Qing Li 1 3, Gabriela D A Guardia 4, Jennifer Chiou 5, Caihong Yi 1, Debashish Ray 6, Fabiana Meliso 4, Yi-Ming Li 3, Talia Delambre 1, Mei Qiao 1, Suzanne S Burns 1, Franziska K Lorbeer 1, Fanny Georgi  …


PNAS: Necroptosis-based CRISPR knockout screen reveals Neuropilin-1 as a critical host factor for early stages of murine cytomegalovirus infection

August 3, 2020

Rebecca K Lane 1, Hongyan Guo 2, Amanda D Fisher 1, Jonathan Diep 3, Zhao Lai 4 5, Yidong Chen 5 6, Jason W Upton 7, Jan Carette 3, Edward S Mocarski 8, William J Kaiser 9 Abstract Herpesviruses are ubiquitous human pathogens that cause a wide range of …


UNITED PRESS INTERNATIONAL – Researchers identify enzyme that helps COVID-19 evade immune system (Gupta Lab)

July 30, 2020

Researchers announced Friday that they have discovered an enzyme that helps COVID-19 enter cells in the human body, allowing the infection to grow. Called non-structural protein 16, or nsp16, the enzyme is produced by the new coronavirus and acts as a …


NEWS 4 WOAI: Decoding Coronavirus Structure Could Lead to New Antiviral Drugs (Gupta lab)

July 28, 2020

SOURCE: WOAI Broadcast Date: July 27, 2020 A new discovery by researchers right here in San Antonio is giving doctors a better idea about how the coronavirus works. “I’m still not 100 percent,” said Rudy Palacios, a man who battled COVID-19 in a hospit …