mBio: Identification and characterization of a SARS-CoV-2 Mpro G23 deletion ensitrelvir-resistant mutant (Gupta Lab)
June 8, 2026Yao Ma, R. Rahisuddin, Sara H. Mahmoud, Anastasija Cupic, Ahmed Magdy Khalil, Esteban Castro, Nathaniel Jackson, Mahmoud Bayoumi, Shailee Arya, Yogesh K. Gupta, Adolfo García-Sastre , Richard K. Plemper, Luis Martinez-Sobrido ABSTRACT Ensitrelvir is an …
Nature Structural & Molecular Biology: Structural insight into how RAD51 paralog exchange regulates RAD51 filament formation (Sung Lab, Hromas, Zhou, Zhao, Wasmuth, Olsen)
June 5, 2026Yashpal Rawal, Youngho Kwon, Lijia Jia, Eliza A. Ruben, Jae-Hoon Ji, Lijuan Guo, Caleb M. Stratton, Digant Nayak, Miriam Tovar, Qingming Fang, Mohd Azrin Jamalruddin, Shuo Zhou, Sahiti Kuppa, Shahrez Syed, Angela M. Jasper, Jeffrey N. Katz, Cody M. Rog …
What if we could stop chronic pain before it starts? (Lai Lab)
May 6, 2026Nature Communications: Highly mutagenic copying of telomeric circles promotes ALT establishment (Malkova Lab)
May 5, 2026Meng-Chia Tsai, Jacob M. Wells, Kelley A. Renninger, Kendra Musmaker, Ryan Pellow, Andrey Malkov, Josep M. Comeron & Anna Malkova Abstract Alternative lengthening of telomeres (ALT) is a recombination-based pathway that enables cancer cells to main …
Nature Structural & Molecular Biology: Structural insight into how RAD51 paralog exchange regulates RAD51 filament formation (Rao, Libich, Wasmuth, Sung, Olsen et al)
April 24, 2026Yashpal Rawal, Youngho Kwon, Lijia Jia, Eliza A. Ruben, Jae-Hoon Ji, Lijuan Guo, Caleb M. Stratton, Digant Nayak, Miriam Tovar, Qingming Fang, Mohd Azrin Jamalruddin, Shuo Zhou, Sahiti Kuppa, Shahrez Syed, Angela M. Jasper, Jeffrey N. Katz, Cody M. Rog …
Science Advances: Selective elimination of circulating effector CD8 T cells via LTβR blockade separates anti-CD137 efficacy from toxicity (Lai, Chen)
April 24, 2026Sergey A. Shein Anna A. Korchagina Li-Ju Wang Zhao Lai, Yidong Chen Jacob S. Fisher Burkhard Ludewig Jessica N. Lancaster Yang-Xin Fu , Ekaterina Koroleva and Alexei V. Tumanov Abstract The major barrier to clinical translation of αCD137 immunothe …
Journal of Applied Physiology: Hyperactive Muscle mTORC1 Attenuates Functional Adaptations to Endurance Training Despite Alterations in Mitochondrial and Lipid Profiles (Lai Lab)
April 24, 2026Abstract Mechanistic target of rapamycin complex I (mTORC1) is a key regulator of cell growth and metabolism, and its activity increases with aging. Hyperactivation of mTORC1 is associated with the pathology of sarcopenia and mitochondrial dysfunction. …
Journal of Biological Chemistry: Structural Basis for the Mechanism and Stability of the EEPD1 5’ Endonuclease (Gupta Lab)
April 10, 2026Robert A. Hromas1,∗ guptay@uthscsa.edu ∙ Aruna S. Jaiswal1,∗ ∙ Anurag Misra2,∗ ∙ Yaxia Yuan3 ∙ Daohong Zhou3 ∙ John I. Beckman2 ∙ Shailee Arya2 ∙ Adhishree Chidambaram2 ∙ Alexander B. Taylor2 ∙ Wendell Griffith4 ∙ Arunima Jaiswal1 ∙ Elizabeth A. Willia …
Nature Structural & Molecular Biology: Resolution of R-loops and transcription–replication conflicts by SETX–BRCA1–BARD1 complex (Sung Lab, Rao Lab)
April 1, 2026Abstract Senataxin (SETX), an RNA–DNA helicase, accumulates at transcription pause sites through the tumor suppressor BRCA1. Here, we provide mechanistic insight into how SETX–BRCA1 resolves transcription-associated R-loops to prevent deleterious outco …
Cancers: Biological Advances and Current Challenges for Pediatric Rhabdomyosarcoma (Houghton, Ignatius, et al)
March 30, 2026by Katie E. Hebron, Patience Odeniyide, Yun Wei, Berkley E. Gryder, G. Barr, Dana L. Casey, Eleanor Y. Chen, Brian D. Crompton, Filemon S. Dela Cruz, Adam D. Durbin, Heide L. Ford, Susanne A. Gatz, Mark E. Hatley, Anton G. Henssen, Simone Hettmer, Pete …