Greehey CCRI Archives
JCO Precision Oncology: Disparate Rates of Germline Variants in Cancer Predisposition Genes in African American/Black Compared With Non-Hispanic White Individuals Between 2015 and 2022 (Tomlinson)
July 12, 2024Rachel B. Wyatt Castillo, MS, CGC, Sarah M. Nielsen, MS, CGC, Elaine Chen, PhD, Brandie Heald, MS, CGC,, Rachel E. Ellsworth, PhD Edward D. Esplin, MD, PhD, FACMG, and Gail E. Tomlinson, MD, PhD Abstract Purpose African American/Black (AA/B) individu …
eLife: SERBP1 interacts with PARP1 and is Present in PARylation-Dependent Protein Complexes Regulating Splicing, Cell Division, and Ribosome Biogenesis (Penalva, Libich, et al)
July 3, 2024Kira Breunig Xiufen Lei Mauro Montalbano Gabriela D. A. Guardia Shiva Ostadrahimi Victoria Alers Adam Kosti Jennifer Chiou Nicole Klein Corina Vinarov Lily Wang Mujia Li Weidan Song W. Lee Kraus David S. Libich Stefano Tiziani Susan T. Weintraub Pedro …
Scientific Reports: STEAP2 promotes hepatocellular carcinoma progression via increased copper levels and stress-activated MAP kinase activity (Chen)
June 20, 2024Carla Zeballos Torrez, Acarizia Easley, Hakim Bouamar, Guixi Zheng, Xiang Gu, Junhua Yang, Yu-Chiao Chiu, Yidong Chen, Glenn A. Halff, Francisco G. Cigarroa Lu-Zhe Sun Abstract Six Transmembrane Epithelial Antigen of Prostate 2 (STEAP2) belong to a fam …
MDPI Cancers: Synergistic Antitumor Activity of Talazoparib and Temozolomide in Malignant Rhabdoid Tumors (Kurmasheva, Lai, & Chen)
June 18, 2024Elena Mironova, Sebastian Molinas, Vanessa Del Pozo, Abhik M. Bandyopadhyay, Zhao Lai, Dias Kurmashev, Eric L. Schneider, Daniel V. Santi, Yidong Chen, Raushan T. Kurmasheva Simple Summary Mutation of the SMARCB1 gene can cause one …
Neoplasia: Aurkin-A, a TPX2-aurora a small molecule inhibitor, disrupts Alisertib-induced polyploidy in aggressive diffuse large B cell lymphoma. (Sung Lab)
June 18, 2024Patrick J Conway 1, Bárbara De La Peña Avalos 2, Jonathan Dao 3, Sebastian Montagnino 4, Dmytro Kovalskyy 2, Eloise Dray 5, Daruka Mahadevan 6 Abstract Chemotherapy-induced polyploidy is a mechanism of inherited drug resistance resulting in an aggressi …
Cell Death & Disease: Impact of the thyroid hormone T3 and its nuclear receptor TRα1 on colon cancer stem cell phenotypes and response to chemotherapies (Penalva)
May 2, 2024Maria Virginia Giolito, Serguei Bodoirat, Theo La Rosa, Mathieu Reslinger, Gabriela D. A. Guardia, Jana Mourtada, Leo Claret, Alain Joung, Pedro A. F. Galante, Luiz O. F. Penalva & Michelina Plateroti Abstract Colorectal cancers (CRCs) are highly h …
Current Protocols: Approaches for Mapping and Analysis of R-loops (Bishop Lab)
April 29, 2024Pramiti Mukhopadhyay, Henry Miller, Aiola Stoja, Alexander J. R. Bishop Abstract R-loops are nucleic acid structures composed of a DNA: RNA hybrid with a displaced non-template single-stranded DNA. Current approaches to identify and map R-loop formatio …
Patterns: Predicting drug response through tumor deconvolution by cancer cell lines (Chen Lab)
April 23, 2024Yu-Ching Hsu 1 2 3 4, Yu-Chiao Chiu 5 6, Tzu-Pin Lu 3, Tzu-Hung Hsiao 7, Yidong Chen 4 8 9 Highlights •Scaden-CA is a deep-learning model for tumor deconvolution •Tumor deconvolution facilitates the use of a drug response prediction algorithm •The mode …
Journal of the American Chemical Society: ights into Molecular Diversity within the FUS/EWS/TAF15 Protein Family: Unraveling Phase Separation of the N-Terminal Low-Complexity Domain from RNA-Binding Protein EWS (Libich Lab)
April 8, 2024Abstract The FET protein family, comprising FUS, EWS, and TAF15, plays crucial roles in mRNA maturation, transcriptional regulation, and DNA damage response. Clinically, they are linked to Ewing family tumors and neurodegenerative diseases such as amyo …
Frontiers in Cell and Developmental Biology: Editorial: RNA-binding proteins in cancer: advances in translational research (Penalva)
March 27, 2024Caterina Mancarella1* Nadine Bley2 Luiz O. F. Penalva3,4 RNA-binding proteins (RBPs) regulate RNA metabolism, processing, and translation by establishing highly dynamic interactions with hundreds of coding and non-coding target RNAs within ribonucleopr …