Greehey CCRI News & Events Archive

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Development: The murine intestinal stem cells are highly sensitive to the modulation of the T3/TRα1-dependent pathway (Penalva Lab)

March 30, 2021

Matthias Godart, Carla Frau, Diana Farhat, Maria Virginia Giolito, Catherine Jamard, Clementine Le Nevé, Jean-Noel Freund, Luiz O. Penalva, Maria Sirakov, Michelina Plateroti Abstract The thyroid hormone T3 and its nuclear receptor TRα1 control gut dev …


MDPI: Musashi1 Contribution to Glioblastoma Development via Regulation of a Network of DNA Replication, Cell Cycle and Division Genes (Penalva Lab)

March 30, 2021

Mirella Baroni 1,†,  OrcID,Caihong Yi 1,2,†,  Saket Choudhary 3,†,  Xiufen Lei 1,  Adam Kosti 1,4,   Denise Grieshober 1,  Mitzli Velasco 1,  Mei Qiao 1,  Suzanne S. Burns 1,‡,  Patricia R. Araujo 1,  Talia DeLambre 1,  Mi Young Son 5,  Michelina Plate …


Cell Cycle: Regulation of DNA duplication by the mTOR signaling pathway (Houghton)

March 11, 2021

ABSTRACT Accurate and complete DNA replication and separation are essential for genetic information inheritance and organism maintenance. Errors in DNA duplication are the main source of genetic instability. Understanding DNA duplication regulation is …


FASEB Journal: Identification of a novel mechanism for meso‐tetra (4‐carboxyphenyl) porphyrin (TCPP) uptake in cancer cells

February 25, 2021

            David J. Elzi,   William E. Bauta,  Jamila R. Sanchez,  Trisha Das, Shweta Mogare, Peter Zannes Fatland,  Moises Iza, Alexander Pertsemlidis,  Vivienne I. Rebel  Abstract Porphyrins are used for cancer diagnost …


Cancer Research: A Very Long-Acting PARP Inhibitor Suppresses Cancer Cell Growth in DNA Repair-Deficient Tumor Models (Houghton, Kurmasheva)

February 19, 2021

Shaun D. Fontaine, Gary W. Ashley, Peter J. Houghton, Raushan T. Kurmasheva, Morgan Diolaiti, Alan Ashworth, Cody J. Peer, Ryan Nguyen, William D. Figg Sr., Denis R. Beckford-Vera, and Daniel V. Santi Abstract PARP inhibitors are approved for the treat …


Cancer Letters: Androgen deprivation-induced elevated nuclear SIRT1 promotes prostate tumor cell survival by reactivation of AR signaling

February 19, 2021

Author links open overlay panels high-BoHuanga, D.Thapaa, A.R.Munoza, S.S.Hussaina, X.Yanga, R.G.Bedollaa, P.Osmulskib, M.E.Gaczynskab, Z.Laibg, Yu-ChiaoChiug, Li-JuWanggY.Chendfg, P.Rivasa, C.Shuddea, R.L.Reddickc, H.Miyamotoh, R.Ghoshabf, A.P.Kumarab …


Clinical Cancer Research: The B7-H3-targeting antibody-drug conjugate m276-SL-PBD is potently effective against pediatric cancer preclinical solid tumor models

February 15, 2021

Nathan M. Kendsersky, Jarrett M Lindsay, Edward A. Kolb, Malcolm A. Smith, Beverly A. Teicher, Stephen Erickson, Eric J Earley, Yaël P. Mossé, Daniel Martinez, Jennifer Pogoriler, Kateryna Krytska, Khushbu Patel, David Groff, Matthew Tsang, Samson Ghil …


Oncogene: MNK1 and MNK2 enforce expression of E2F1, FOXM1, and WEE1 to drive soft tissue sarcoma

February 9, 2021

Xin-Yu Ke, Ye Chen, Valarie Yu-Yan Tham, Ruby Yu-Tong Lin, Pushkar Dakle, Kassoum Nacro, Mark Edward Puhaindran, Peter Houghton, Angela Pang, Victor Kwanmin Lee, Ling-Wen Ding, Sigal Gery, Jeffrey Hill, Leilei Chen, Liang Xu & H. Phillip Koeffler A …


Cell Press: A Modular Master Regulator Landscape Controls Cancer Transcriptional Identity (Zheng Lab)

January 21, 2021

Evan O.Paull114,  Alvaro Aytes121314,  Sunny J.Jones114,  Prem S.Subramaniam1,  Federico M.Giorgi3,  Eugene F.Douglass1,  Somnath Tagore1,  Brennan Chu1,  Alessandro Vasciaveo1,  Siyuan Zheng4,  Roel Verhaak5,  Cory Abate-Shen1678,  Mariano J.Alvarez19 …


Methods: Prediction and interpretation of cancer survival using graph convolution neural networks

January 21, 2021

RicardoRamireza, Yu-ChiaoChiub, SongYaoZhangc, JoshuaRamireza, YidongChenbd, YufeiHuangad, Yu-FangJina Highlights •  Predicting cancer survival outcomes using Graph Convolutional Neural Networks with TCGA dataset. •  Combining clinical data and the GCN …