Nature Structural & Molecular Biology: Cryo-EM structures reveal the molecular mechanism of SUMO E1–E2 thioester transfer (Olsen Lab, Sung Lab)
September 26, 2025Anindita Nayak, Digant Nayak, Lijia Jia, Eliza A. Ruben, Suryavathi Viswanadhapalli, Priscila dos Santos Bury, Khaled Mohamed Nassar, Corey H. Yu, Anna A. Tumanova, Caleb M. Stratton, Pirouz Ebadi, Dmitri N. Ivanov, Patrick Sung, Ratna K. Vadlamudi, El …
BioRxiv: Phosphoregulation of RAD51AP1 function in homology-directed repair (Sung Lab)
September 22, 2025Neelam Sharma, Mollie Uhrig, Youngho Kwon, Patrick Sung, Claudia Wiese ABSTRACT Homology-directed DNA repair (HDR) is critical for genome stability and tumor suppression. HDR is initiated by the RAD51 single-stranded (ss)DNA nucleoprotein filament whi …
Protein Science: Molecular basis of EWS interdomain self-association and its role in condensate formation (Libich Lab)
September 22, 2025Erich J. Sohn, Kandarp A. Sojitra, Leticia Rodrigues, Xiaoping Xu, Bess Frost, Jeetain Mittal, David S. Libich Abstract Ewing sarcoma, the second most common pediatric bone and soft tissue cancer, is caused by the aberrant fusion of the RNA-binding pro …
Trends in Biochemical Sciences: E3 Ubiquitin Ligases in Signaling, Disease, and Therapeutics (Olsen)
September 15, 2025Pirouz Ebadi 1, Caleb M Stratton 1, Shaun K Olsen 2 Abstract The ubiquitin-proteasome system (UPS) is a central regulator of protein turnover and signaling, with E3 ubiquitin ligases conferring substrate specificity and chain-type control. Recent advan …
Aging Cell: Inhibition of Hippo Signaling Through Ablation of Lats1 and Lats2 Protects Against Cognitive Decline in 5xFAD Mice via Increasing Neuronal Resilience Against Ferroptosis (Zheng)
September 10, 2025Robert C. Evans, Nawab John Dar, Liuji Chen, Ren Na, Jason C. O’Connor, Jing Jiang, Siyuan Zheng, Qitao Ran ABSTRACT The Hippo signaling pathway is a key regulator of cell growth and cell survival, and hyperactivation of the Hippo pathway has been impl …
Biochemistry: The Spliceosomal Peptidyl Prolyl Isomerase Like 1 Interacts with the Low-Complexity Domain of the RNA Binding Protein EWS Modulating Its Phase Separation Behavior (Libich Lab)
August 8, 2025George L Parra 1, Erich J Sohn 1, Xiaoping Xu 1, David S Libich 1 Abstract RNA-binding protein EWS, a member of the FET (FUS, EWS, TAF15) family, contributes to mRNA biogenesis through roles in transcription, splicing, and RNA transport. Despite eviden …
Molecular Cell: PALB2 and 53BP1 govern post-resection homologous recombination DNA repair (Sung Lab)
August 4, 2025Yifan Wang 1, Yan Coulombe 2,Wei-Ting Yueh 1,Gregory D. Conway 1,Larissa Milano 2,David J. Glass 1 3,Mélissa Thomas 2,Amélie Rodrigue 2,Joseph Nacson 1,Dongbo Lu 4,Andrea J. Bernhardy 1, Robert G. Betsch 1,Alyssa I. Russo 1,Gamal A. Elfar 1,Kathy Q. Ca …
Journal of Applied Physiology: Evaluating the effects of exercise and phellodendron amurense on cardiac function in a prostate cancer mouse model (Aune Lab)
August 4, 2025Neha Kumar, Logan R. Davis, Gregory J. Aune Paul Rivas, Addanki P. Kumar, Darpan I. Patel Abstract Cytotoxic treatments pose a significant cardiotoxic risk to men with prostate cancer (PCa). Exercise has been found to prevent cardiotoxicities. Previous …
Cancer Epidemiology Biomarkers Prevention: Multiancestry Transcriptome-Wide Association Study Identifies Candidate Genes Associated with Hepatoblastoma (Tomlinson)
August 1, 2025Tiankai Xie Josey C. Sorenson Logan G. Spector Nathan Pankratz R. Stephanie Huang Eiso Hiyama Jenny N. Poynter Gail E. Tomlinson Carolina Armengol Roland Kappler Michael E. Scheurer Eve Roman Aurora Castellano Michael A. Grotzer David S. Ziegler Saonli …
Journal of Clinical Investigation: Efficacy and safety of a therapeutic humanized FSH–blocking antibody in obesity and Alzheimer’s disease models (Gupta)
July 30, 2025Anusha R. Pallapati,1 Funda Korkmaz,1 Satish Rojekar,1 Steven Sims,1 Anurag Misra,2 Judit Gimenez–Roig,1 Aishwarya Gangadhar,1 Victoria Laurencin,1 Anissa Gumerova,1 Uliana Cheliadinova,1 Farhath Sultana,1 Darya Vasilyeva,1 Liam Cullen,1 Jonathan Schue …