BioRxiv: Diverse Mechanisms of SMARCB1 Inactivation and Genome Maintenance Defects in Ultra-Rare Malignant Rhabdoid Tumors (Kurmasheva Lab, Chen, Lai)
March 27, 2026Elizabeth Rasmussen, Elena Mironova, Zhao Lai, Kendra Maaß, Stefanie Volz, Dias Kurmashev, Stefan M. Pfister, Yidong Chen, Raushan T. Kurmasheva ABSTRACT Malignant rhabdoid tumors (MRTs) are extremely rare and highly aggressive pediatric cancers classi …
BioRxiv: Intrinsically disordered SERBP1 regulates translation through topology-driven G-quadruplex recognition (Libich Lab)
March 19, 2026Antoine Baudin, Hoang H. Dinh, Kira Breunig, Xuifen Lei, Xiaoping Xu, View Luiz O. Penalva, David S. Libich Abstract Serpine mRNA-binding protein 1 (SERBP1) is an intrinsically disordered RNA-binding protein that regulates translat …
iScience: Predicting and interpreting protein and phosphoprotein abundance from pan-cancer and single-cell transcriptomes (Chen Lab)
March 12, 2026Hui-Mei Tsai1,2,3,12 ∙ Tzu-Hung Hsiao2,4,5,12 ∙ Yu-Chiao Chiu6,7 ∙ Yufei Huang6,7 ∙ Eric Y. Chuang1,8,9,10 chuangey@ntu.edu.tw ∙ Yidong Chen3,11,13 cheny8@uthscsa.edu Highlights • DeepGxP provides a framework to translate transcriptomes into proteomic …
Chemical Science: Unveiling BCL-xL-specific PROTAC efficiency and dissociation pathways using native mass spectrometry (Olsen, Zhou)
February 24, 2026Mohamed I. Gadallah, Kailyn L. Nonhof, Digant Nayak, Peiyi Zhang, Olivia Dioli, Guangrong Zheng, Shaun K. Olsen, Daohong Zhou and Jennifer S. Brodbelt Author affiliations Abstract Overexpression of anti-apoptotic proteins such as BCL-xL …
Haematologica: IGF2BP3 inhibition: another home run for RNA-binding protein targeting in hematological malignancies (Penalva)
February 10, 2026Luiz O.F. Penalva RNA-binding proteins (RBPs) are critical regulators of gene expression, aNecting RNA processing till translation. More than 1,500 proteins have been catalogued as RBPs in the human genome. 1 RBPs are very diverse in respect to structu …
BioRxiv: High-throughput mapping of 6,888 RAD51D variants identifies distinct biochemical functions needed for homologous recombination and olaparib response (Sung)
January 30, 2026Kristie E. Darrah, Shelby L. Hemker, Yashpal Rawal, Noah J. Goff, Phoebe Parker, Gayatri Ganesan, Caleb M. Stratton, Katherine Oppenheimer, Ella Roberts, Elena Glick, Nicole Banks, Arjun Kumar, Silvia Casadei, Matthew W. Snyder, Katherine Nathanson, Su …
Journal of Biological Chemistry: Phosphoregulation of RAD51AP1 function in homology-directed repair (Sung Lab)
January 16, 2026Neelam Sharma1 ∙ Mollie E. Uhrig1,2 ∙ Youngho Kwon3 ∙ Patrick Sung3 ∙ Claudia Wiese1 cwiese@colostate.edu ABSTRACT Homology-directed DNA repair (HDR) is critical for genome stability and tumor suppression. HDR is initiated by the RAD51 single-stranded …
BioMolecules: The PELP1 Pathway and Its Importance in Cancer Treatment (Rao Lab)
January 13, 2026Khaled Mohamed Nassar Panneerdoss Subbarayalu Suryavathi Viswanadhapalli Ratna K. Vadlamudi Abstract Proline-, glutamic acid-, and leucine-rich protein 1 (PELP1) is a proto-oncogene that serves as a nuclear and cytoplasmic scaffolding protein. PELP1 p …
Star Protocols: Transformer and graph variational autoencoder to identify microenvironments: A deep learning protocol for spatial transcriptomics (Chen)
January 6, 2026Karla Paniagua 1 8, Yufei Huang 2 3 4, Shou-jiang Gao 2 5, Yidong Chen 6 7, Yu-Fang Jin 1, Mario Flores 1 9 Highlights Workflow to build spatial objects linking stitched images with transcriptomics data Steps to apply the transformer and GraphVAE for s …
Editorial: Efficacy of larotrectinib in pediatric cancers with NTRK gene fusions (Houghton)
December 31, 2025Peter J Houghton 1, Mary-Ann Bjornsti 2 PMID: 41502892 PMCID: PMC12771222 DOI: 10.21037/tp-2025-664 No abstract available Figures Figure 1 Signaling pathways downstream of ligand… Figure 2 Schema showing characteristics of fusion… Comment on Elective D …