Greehey CCRI News & Events Archive

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Cancer Letters: COX-2 promotes mammary adipose tissue inflammation, local estrogen biosynthesis, and carcinogenesis in high-sugar/fat diet treated mice

January 9, 2021

Author links open overlay panelRosângela MayerGonçalvesa,  MarinaDelgoboa, Jonathan PauloAgnesa, Raquel Nascimentodas Nevesa, MarceloFalchettia, TuanyCasagrandea, Ana Paula VargasGarciab, Thaynan CunhaVieirab, NauanaSomensic, Maciel AlencarBruxeld, Dan …


MDPI: MSI1 Promotes the Expression of the GBM Stem Cell Marker CD44 by Impairing miRNA-Dependent Degradation

December 5, 2020

Rebecca Pötschke  1,2,†, Jacob Haase  1,†, Markus Glaß  1, Sebastian Simmermacher  3, Claudia Misiak  1, Luiz O. F. Penalva  4,5, Caspar D. Kühnöl  2,* and Stefan Hüttelmaier  1,* Simple Summary Glioblastoma (GBM) is the most lethal brain tumor with a …


Molecular Oncology: Interaction of transcription factor AP‐2 gamma with proto‐oncogene PELP1 promotes tumorigenesis by enhancing RET signaling

December 2, 2020

Junhao Liu, Zexuan Liu, Mengxing Li, , Weiwei Tang, Uday P. Pratap, Yiliao Luo, Kristin A. Altwegg, Xiaonan Li, Yi Zou, Hong Zhu, Gangadhara R. Sareddy,  Suryavathi Viswanadhapalli, Ratna K. Vadlamudi Abstract A significant proportion of estrogen recep …


PNAS: Oncogenic allelic interaction in Xiphophorus highlights hybrid incompatibility

November 24, 2020

Yuan Lu,  View ORCID ProfileAngel Sandoval,  View ORCID ProfileSarah Voss, Zhao Lai, Susanne Kneitz, Will Boswell, Mikki Boswell, Markita Savage,  View ORCID ProfileChristi Walter, Wes Warren,  View ORCID ProfileManfred Schartl, and Ronald Walter Abstr …


Mucosal Immunology: Campylobacter infection promotes IFNγ-dependent intestinal pathology via ILC3 to ILC1 conversion

November 19, 2020

Wayne T. Muraoka, Anna A. Korchagina, Qingqing Xia, Sergey A. Shein, Xi Jing, Zhao Lai, Korri S. Weldon, Li-Ju Wang, Yidong Chen, Lawrence W. Kummer, Markus Mohrs, Eric Vivier, Ekaterina P. Koroleva & Alexei V. Tumanov Abstract Innate lymphoid cell …


Nature Communications: Integrative transcriptome and chromatin landscape analysis reveals distinct epigenetic regulations in human memory B cells (Pertsemlidis)

November 16, 2020

Justin B. Moroney, Anusha Vasudev, Alexander Pertsemlidis, Hong Zan & Paolo Casali Abstract Memory B cells (MBCs) are long-lived and produce high-affinity, generally, class-switched antibodies. Here, we use a multiparameter approach involving CD27 …


Cell Reports: GDF6-CD99 Signaling Regulates Src and Ewing Sarcoma Growth

November 3, 2020

Fuchun Zhou (1), David J.Elzi (1, 2), Panneerselvam Jayabal(1), Xiuye Ma(1), Yu-Chiao Chiu (1) Yidong Chen 1,3,4) Barron Blackman(1) Susan T.Weintraub (4, 5) Peter J.Houghton 1,4,6) Yuzuru Shiio (1,4,5,7) Highlights The autocrine signaling mediated by …


MedicalXpress – One Mouse at a Time: a New Approach to Testing Potential Drugs for Children’s Cancers (Houghton, Kurmasheva, PPTC)

October 22, 2020

by European Organisation for Research and Treatment of Cancer A team of researchers in the US and Australia have developed a way of testing potential drugs for children’s cancers so as to take account of the wide genetic diversity of these diseases. In …


Greehey CCRI Director, Peter J. Houghton, PhD and Members of His Lab Co-Author Pediatric Blood & Cancer Paper

October 14, 2020

Radiation therapy and molecular‐targeted agents in preclinical testing for immunotherapy, brain tumors, and sarcomas: Opportunities and challenges Ralph Vatner, Charles D. James, Vythialingam Sathiaseelan, Kathryn M. Bondra, John A. Kalapurakal, Peter …


Breast Cancer Research and Treatment: KDM1A inhibition is effective in reducing stemness and treating triple negative breast cancer

October 14, 2020

Abstract Purpose Cancer stem cells (CSCs) are highly tumorigenic, spared by chemotherapy, sustain tumor growth, and are implicated in tumor recurrence after conventional therapies in triple-negative breast cancer (TNBC). Lysine-specific histone demethy …


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