Greehey CCRI News & Events Archive

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Biochemistry: Confinement and Stabilization of Fyn SH3 Folding Intermediate Mimetics within the Cavity of the Chaperonin GroEL Demonstrated by Relaxation-Based NMR

February 21, 2017

David S Libich 1, Vitali Tugarinov 1, Rodolfo Ghirlando 1, G Marius Clore 1 Abstract The interaction of two folding intermediate mimetics of the model protein substrate Fyn SH3 with the chaperonin GroEL, a supramolecular foldase/unfoldase machine, has …


Journal of Clinical Oncology: Successful integration of genetic counseling in a comprehensive childhood cancer survivorship clinic.

February 10, 2017

Shafqat Shah, Gregory John Aune, Lindsey Mette, Natalie Poullard Background: Awareness of inherited genetic risk and cancer predisposition has markedly increased. Research has shown that germline mutations in known cancer predisposition genes are ident …


Bioinformatics: Riborex: fast and flexible identification of differential translation from Ribo-seq data

January 31, 2017

Authors Wenzheng Li, Weili Wang, Philip J Uren, Luiz OF Penalva, Andrew D Smith Abstract Motivation Global analysis of translation regulation has recently been enabled by the development of Ribosome Profiling, or Ribo-seq, technology. This approach pro …


Pediatric Hematology Oncology: Paraneoplastic Galactorrhea in Childhood T-ALL: An Evaluation of Tumor-derived Prolactin

January 1, 2017

Allison Grimes 1, Nooshin Mirkheshti, Bandana Chatterjee, Gail Tomlinson, Chatchawin Assanasen Abstract T-cell acute lymphoblastic leukemia (T-ALL) comprises 15% of childhood leukemia. Although multiagent pulse chemotherapy has improved event-free surv …


Washington Post: A new urgency to protect survivors of childhood cancer

December 25, 2016

SAN ANTONIO — When Brittany Galan was diagnosed with leukemia at 6 weeks old, doctors warned her parents she had little chance of surviving — she was so young and so sick. But after being treated with chemotherapy, “I lived and lived!” said the exubera …


Developmental Cell: CENP-A Ubiquitylation Is Required for CENP-A Deposition at the Centromere

December 20, 2016

YoheiNiikura1, RisaKitagawa1, KatsumiKitagawa1 Main Text CENP-A is a centromere-specific histone variant that determines centromere identity, but how it localizes to centromeres is not completely understood. Previously, we demonstrated that CENP-A depo …


Ft. Worth Business: Cancer treatments that save children’s lives exact a heavy price years later

December 16, 2016

The lifesaving chemo, however, took a heavy toll. It “messed me up neurologically,” Galan said. In grade school, she had trouble with reading and math and eventually went on ADHD medication. In college, the once-avid runner developed a heart problem. R …


IEEE Xplore: Analyzing Differential Regulatory Networks Modulated by Continuous-State Genomic Features in Glioblastoma Multiforme

December 5, 2016

Yu-Chiao Chiu; Tzu-Hung Hsiao; Li-Ju Wang; Yidong Chen; Eric Y. Chuang Abstract: Gene regulatory networks are a global representation of complex interactions between molecules that dictate cellular behavior. The study of a regulatory network modulated …


Genome Biology: Functional genomics analyses of RNA-binding proteins reveal the splicing regulator SNRPB as an oncogenic candidate in glioblastoma

December 1, 2016

Bruna R Correa, Patricia Rosa de Araujo, Mei Qiao, Suzanne C Burns, Chen Chen, Richard Schlegel, Seema Agarwal, Pedro AF Galante, Luiz OF Penalva Background Glioblastoma (GBM) is the most common and aggressive type of brain tumor. Currently, GBM has an …


Molecular Cancer Therapeutics: Alkylating Agent–Induced NRF2 Blocks Endoplasmic Reticulum Stress–Mediated Apoptosis via Control of Glutathione Pools and Protein Thiol Homeostasis

December 1, 2016

Alfeu Zanotto-Filho, V. Pragathi Masamsetti, Eva Loranc, Sonal S. Tonapi, Aparna Gorthi, Xavier Bernard, Rosângela Mayer Gonçalves, José C.F. Moreira, Yidong Chen and Alexander J.R. Bishop Abstract Alkylating agents are a commonly used cytotoxic class …


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