Greehey CCRI Archives
BMG Medical Genomics: Convolutional neural network models for cancer type prediction based on gene expression
April 3, 2020Milad Mostavi, Yu-Chiao Chiu, Yufei Huang & Yidong Chen Abstract Background Precise prediction of cancer types is vital for cancer diagnosis and therapy. Through a predictive model, important cancer marker genes can be inferred. Several studies hav …
Pain Reports: Reliable approaches to extract high-integrity RNA from skin and other pertinent tissues used in pain research
March 27, 2020Peter M LoCoco 1, Jacob T Boyd 1, Claudia M Espitia Olaya 2, Ashley R Furr 1, Dawn K Garcia 3, Korri S Weldon 3, Yi Zou 3, Erin Locke 1, Alejandro Tobon 4, Zhao Lai 3 5, Shivani B Ruparel 1, Nikita B Ruparel 1, Kenneth M Hargreaves 1 Abstract Introduct …
Katsumi Kitagawa, Pharm.D., PhD Awarded $1M NSF Grant
March 16, 2020Overview: Centromeres are essential for chromosome segregation during mitosis. The kinetochore is the protein complex associated with the centromere. Dysfunction in centromeres causes chromosome instability and can result in aneuploidy. The overall goa …
bioRxiv : Assessing the Heterogeneity of Cardiac Non-myocytes and the Effect of Cell Culture with Integrative Single Cell Analysis
March 4, 2020Abstract Cardiac non-myocytes comprise a diverse and crucial cell population in the heart that plays dynamic roles in cardiac wound healing and growth. Non-myocytes broadly fall into four cell types: endothelium, fibroblasts, leukocytes, and pericytes. …
Greehey CCRI Receives Its First NIH K99 Award (Chen Lab)
March 2, 2020Yu-Chiao Chiu, PhD, a postdoctoral researcher at the Greehey Children’s Cancer Research Institute (GCCRI), received the prestigious NIH Pathway to Independence Award (K99/R00) from the National Cancer Institute (NCI). The highly co …
Clinical Cancer Research: EGFR Amplification Induces Increased DNA Damage Response and Renders Selective Sensitivity to Talazoparib (PARP Inhibitor) in Glioblastoma
March 1, 2020Shaofang Wu 1, Feng Gao 1, Siyuan Zheng 2, Chen Zhang 1, Emmanuel Martinez-Ledesma 1 3, Ravesanker Ezhilarasan 4, Jie Ding 1, Xiaolong Li 1, Ningping Feng 5, Asha Multani 6, Erik P Sulman 4, Roel G Verhaak 2, John F de Groot 1, Tim P Heffernan 5, W K A …
Future Focus: San Antonio lands one of its largest Cancer Grants to Bring in New Talent
February 27, 2020CPRIT officials said this is one of the largest amounts San Antonio institutions have collectively received from the institute in a single funding round since it was established by Texas voters in 2007. CPRIT CEO Wayne Roberts said it’s also further in …
Manjeet Rao, PhD, Awarded NCI, R01 Grant to Test Efficacy of Novel Drug
Dr. Manjeet Rao, Greehey CCRI Deputy Director (interim), was recently awarded a grant from National Cancer Institute ($2.1 million) to test the therapeutic efficacy of a novel drug that can inhibit the function of a protein that is highly expressed in …
Frontiers in Oncology: Nanoformulation of Talazoparib Increases Maximum Tolerated Doses in Combination With Temozolomide for Treatment of Ewing Sarcoma (Kurmasheva Lab)
Paige Baldwin1, Rostislav Likhotvorik2, Nabeela Baig2, Jodie Cropper2, Ruth Carlson2, Raushan Kurmasheva2,3*† and Srinivas Sridhar1,4,5*† The Pediatric Preclinical Testing Program previously identified the PARP inhibitor talazoparib (TLZ) as a me …
Greehey CCRI Faculty Awarded $1.2M CPRIT Grant to Support Osteosarcoma Research
Written by: Will Sansom An award of $1.2 million from the Cancer Prevention and Research Institute of Texas (CPRIT) went to Greehey CCRI Deputy Director and principal investigator Manjeet Rao, PhD, professor of cell systems and anatomy, for studies of …