Greehey CCRI News & Events Archive

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Aging: Aging is associated with an expansion of CD49fhi mammary stem cells that show a decline in function and increased transformation potential

November 15, 2016

Qiaoxiang Dong1,2 , Hui Gao1,2 , Yuanshuo Shi1,3 , Fuchuang Zhang1,3 , Xiang Gu1 , Anqi Wu3 , Danhan Wang3 , Yuanhong Chen3 , Abhik Bandyopadhyay1 , I-Tien Yeh4 , Benjamin J. Daniel5 , Yidong Chen6,8 , Yi Zou8 , Vivienne L. Rebel1,7,8 , Christi A. Walt …


Scientific Reports: Differential network analysis reveals the genome-wide landscape of estrogen receptor modulation in hormonal cancers

November 12, 2016

Tzu-Hung Hsiao, Yu-Chiao Chiu, Pei-Yin Hsu, Tzu-Pin Lu, Liang-Chuan Lai, Mong-Hsun Tsai, Tim H.-M. Huang, Eric Y. Chuang Yidong Chen Abstract Several mutual information (MI)-based algorithms have been developed to identify dynamic gene-gene and functio …


JoVE: Methyl-binding DNA capture Sequencing for Patient Tissues

October 31, 2016

Rohit R Jadhav 1, Yao V Wang 1, Ya-Ting Hsu 1, Joseph Liu 1, Dawn Garcia 2, Zhao Lai 2, Tim H M Huang 1, Victor X Jin 3 Abstract Methylation is one of the essential epigenetic modifications to the DNA, which is responsible for the precise regulation of …


Cancer Chemotherapy and Pharmacology: Identifying novel therapeutic agents using xenograft models of pediatric cancer

May 18, 2016

Raushan T. Kurmasheva & Peter J. Houghton Abstract In the USA, the overall cure rate for all childhood cancers is seventy percent, and in many patients that ultimately fail curative therapy, initial responses to current multimodality treatments (su …


Molecular Cancer Therapy: The Bromodomain BET Inhibitor JQ1 Suppresses Tumor Angiogenesis in Models of Childhood Sarcoma

May 15, 2016

Hemant K Bid 1, Doris A Phelps 1, Linlin Xaio 1, Denis C Guttridge 2, Jiayuh Lin 1, Cheryl London 3, Laurence H Baker 4, Xiaokui Mo 5, Peter J Houghton 6 Abstract The bromodomain and extra-terminal domain inhibitor JQ1 has marked antitumor activity aga …


Biochimica et Biophysica Acta (BBA) – Molecular Basis of Disease: Vascular mTOR-dependent mechanisms linking the control of aging to Alzheimer’s disease

May 1, 2016

Abstract Aging is the strongest known risk factor for Alzheimer’s disease (AD). With the discovery of the mechanistic target of rapamycin (mTOR) as a critical pathway controlling the rate of aging in mice, molecules at the interface between the regulat …


Clinical Cancer Research: Recurrent Mutations of Chromatin-Remodeling Genes and Kinase Receptors in Pheochromocytomas and Paragangliomas

May 1, 2016

Rodrigo A. Toledo, Yuejuan Qin, Zi-Ming Cheng, Qing Gao, Shintaro Iwata, Gustavo M. Silva, Manju L. Prasad, I. Tolgay Ocal, Sarika Rao, Neil Aronin, Marta Barontini, Jan Bruder, Robert L. Reddick, Yidong Chen, Ricardo C.T. Aguiar and Patricia L.M. Dahi …


PLOS One: Combined Gene Expression and RNAi Screening to Identify Alkylation Damage Survival Pathways from Fly to Human

April 21, 2016

Alfeu Zanotto-Filho, Ravi Dashnamoorthy, Eva Loranc, Luis H. T. de Souza, José C. F. Moreira, Uthra Suresh, Yidong Chen, Alexander J. R. Bishop Abstract Alkylating agents are a key component of cancer chemotherapy. Several cellular mechanisms are known …


PLOS One: Combined Gene Expression and RNAi Screening to Identify Alkylation Damage Survival Pathways from Fly to Human

April 21, 2016

Alfeu Zanotto-Filho, Ravi Dashnamoorthy, Eva Loranc, Luis H. T. de Souza, José C. F. Moreira, Uthra Suresh, Yidong Chen, Alexander J. R. Bishop  Abstract Alkylating agents are a key component of cancer chemotherapy. Several cellular mechanisms are know …


JCI Insight: Synergism of FAK and tyrosine kinase inhibition in Ph+ B-ALL

April 17, 2016

Michelle L. Churchman,1 Kathryn Evans,2 Jennifer Richmond,2 Alissa Robbins,2 Luke Jones,2 Irina M. Shapiro,3 Jonathan A. Pachter,3 David T. Weaver,3 Peter J. Houghton,4 Malcolm A. Smith,5 Richard B. Lock,2 and Charles G. Mullighan1 Abstract BCR-ABL1+ B …


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