Greehey CCRI News & Events Archive

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BMC Genomics: Parameter optimization for constructing competing endogenous RNA regulatory network in glioblastoma multiforme and other cancers

April 21, 2015

Yu-Chiao Chiu, Tzu-Hung Hsiao, Yidong Chen & Eric Y Chuang Abstract Background In addition to direct targeting and repressing mRNAs, recent studies reported that microRNAs (miRNAs) can bridge up an alternative layer of post-transcriptional gene reg …


Fitoterapia: Jonquailine, a new pretazettine-type alkaloid isolated from Narcissus jonquilla quail, with activity against drug-resistant cancer

April 1, 2015

Marco Masi 1, Liliya V Frolova 2, Xiaojie Yu 3, Véronique Mathieu 4, Alessio Cimmino 1, Annelise De Carvalho 4, Robert Kiss 4, Snezna Rogelj 2, Alexander Pertsemlidis 3, Alexander Kornienko 5, Antonio Evidente 6 Abstract A new alkaloid, belonging to th …


IEEE Xplore: MeTDiff: A Novel Differential RNA Methylation Analysis for MeRIP-Seq Data

March 2, 2015

Lin Zhang; Jia Meng; Manjeet K. Rao; Yidong Chen; Yufei Huang Abstract: N6-Methyladenosine (m6A) transcriptome methylation is an exciting new research area that just captures the attention of the research community. We present in this paper, MeTDiff, a …


Familial Cancers: Mutations of HNRNPA0 and WIF1 predispose members of a large family to multiple cancers

February 26, 2015

Chongjuan Wei 1, Bo Peng, Younghun Han, Wei V Chen, Joshua Rother, Gail E Tomlinson, C Richard Boland, Damien Chaussabel, Marsha L Frazier, Christopher I Amos Erratum in Erratum to: Mutations of HNRNPA0 and WIF1 predispose members of a large family to …


Genes & Cancer: Microarray profile of human kidney from diabetes, renal cell carcinoma and renal cell carcinoma with diabetes

February 14, 2015

Adam Kosti2, Hung-I Harry Chen4, Sumathy Mohan3, Sitai Liang2, Yidong Chen4,5, and Samy L. Habib1,2 ABSTRACT A recent study from our laboratory showed that patients with diabetes are at a higher risk of developing kidney cancer. In the current study, w …


SA Express-News: Childhood cancer survivor active in Obama’s ‘precision medicine’ effort

February 9, 2015

S.A. scientist also a cancer survivor As a childhood cancer survivor, San Antonio pediatric oncologist Greg Aune understood the excitement felt by cancer patients and their families when President Barack Obama announced his “precision medicine” initiat …


International Journal of Molecular Sciences (MDPI): Potential Relationship between Inadequate Response to DNA Damage and Development of Myelodysplastic Syndrome

January 5, 2015

Ting Zhou 1,2,Peishuai Chen 1,3,Jian Gu 3,Alexander J. R. Bishop 1,2,4,5,Linda M. Scott 6,Paul Hasty 4,5,7 and Vivienne I. Rebel 1,2,4,5,* Abstract Hematopoietic stem cells (HSCs) are responsible for the continuous regeneration of all types of blood ce …


Journal of Biological Chemistry: Hormone-induced and DNA Demethylation-induced Relief of a Tissue-specific and Developmentally Regulated Block in Transcriptional Elongation*

December 19, 2014

Abstract Genome-wide studies have revealed that genes commonly have a high density of RNA polymerase II just downstream of the transcription start site. This has raised the possibility that genes are commonly regulated by transcriptional elongation, bu …


American Journal of Physiology – Heart & Circulatory Physiology: The tell-tale heart: molecular and cellular responses to childhood anthracycline exposure

November 15, 2014

Merry L. Lindsey, Richard A. Lange, Helen Parsons, Thomas Andrews, and Gregory J. Aune Abstract Since the modern era of cancer chemotherapy that began in the mid-1940s, survival rates for children afflicted with cancer have steadily improved from 10% t …


American Journal of Physiology: The tell-tale heart: molecular and cellular responses to childhood anthracycline exposure

November 14, 2014

Abstract Since the modern era of cancer chemotherapy that began in the mid-1940s, survival rates for children afflicted with cancer have steadily improved from 10% to current rates that approach 80% (60). Unfortunately, many long-term survivors of pedi …


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