Computational & Structural Biotechnology: Cell type prediction with neighborhood-enhanced cellular embedding using deep learning on hematoxylin and eosin-stained images (Chen Lab)
July 30, 2025Nam Nhut Phana ∙ Hanzhou Wanga ∙ Tapsya Nayaka ∙ Zhenqing Yea ∙ Yu-Chiao Chiub,c ∙ Yufang Jind ∙ Yufei Huangc,e,f ∙ Yidong Chena,g cheny8@uthscsa.edu Abstract Purpose This study aimed to predict the cell types that infiltrate the tumor microenvironmen …
Cell Reports: IGSF10 is a RET antagonist regulating Ewing sarcoma growth and GnRH neuron migration (Chen, Houghton, & Shiio Lab)
July 24, 2025Panneerselvam Jayabal1 ∙ Xiuye Ma1 ∙ Maleeha Akram2 ∙ Hannah Bow2 ∙ Pranay Mandal2 ∙ Naira Mansano2 ∙ Yidong Chen1,3,4 ∙ Susan T. Weintraub4,5 ∙ Peter J. Houghton1,4,6 ∙ Susan Wray2 ∙ Yuzuru Shiio Highlights Ewing sarcoma depends on IGSF10, which inhib …
BioRxiv: Robust statistical assessment of Oncogenotype to Organotropism translation in xenografted zebrafish (Kurmasheva, et al)
June 24, 2025Abstract Organotropism results from the functional versatility of metastatic cancer cells to survive and proliferate in diverse microenvironments. This adaptivity can originate in clonal variation of the spreading tumor and is often empowered by epigen …
Advanced Science: Biosecurity Primitive: Polymerase X-based Genetic Physical Unclonable Functions (Pertsemlidis)
June 18, 2025Zikun Zhou, Taek Kang, Jie Chen, Yesh Doctor, Jocelyn G Camposagrado, Yiorgos Makris, Alexander Pertsemlidis, Leonidas Bleris Abstract A Physical Unclonable Function (PUF) is a security primitive that exploits inherent variations in manufacturing proto …
BioMolecular NMR Assignments: The 1H, 15N and 13C backbone resonance assignments of the N-terminal (1-149) domain of Serpine mRNA Binding Protein 1 (SERBP1) (Libich Lab)
May 30, 2025Antoine Baudin, Hoang H. Dinh, Xiaoping Xu & David S. Libich Abstract Serpine mRNA-Binding Protein 1 (SERBP1) is an RNA-binding protein implicated in diverse cellular functions, including translational regulation, tumor progression, and stress resp …
Science: CTC1-STN1-TEN1 controls DNA break repair pathway choice via DNA end resection blockade (Sung & Libich Labs)
May 23, 2025Cody M. Rogers, Hardeep Kaur, Michelle L. Swift , Vivek B. Raina , Shuo Zhou , Ajinkya S. Kawale Shahrez Syed , Korilynn G. Kelly , Angela M. Jasper , Sameer Salunkhe, Youngho Kwon , Jeffrey Wang, Aida Badamchi Shabestari, James M. Daley, Adam Sacks , …
PNAS: Phase separation of the oncogenic fusion protein EWS::FLI1 is modulated by its DNA-binding domain (Libich & Bishop Labs)
May 16, 2025Emily E. Selig Erich J. Sohn Aiola Stoja, Alma K. Moreno-Romero, Shivani Akula, Xiaoping Xu, Alexander J. R. Bishop, and David S. Libich Significance The oncogenic fusion protein, EWS::FLI1, responsible for more than 85% of Ewing sarcoma tumors, comb …
Cell Reports: Distinct roles of the two BRCA2 DNA-binding domains in DNA damage repair and replication fork preservation (Sung, Libich Labs)
May 7, 2025Francisco E. Neal1,2 ∙ Wenjing Li1 ∙ Mollie E. Uhrig3,4 ∙ Jeffrey N. Katz1,2 ∙ Shahrez Syed1,2 ∙ Neelam Sharma3 ∙ Arijit Dutta1,2,8 ∙ Sandeep Burma1,5 ∙ Robert Hromas6 ∙ Alexander V. Mazin1 ∙ Eloise Dray1 ∙ David S. Libich1,2 ∙ Shaun K. Olsen1,2 ∙ Eliz …
Trends in Molecular Medicine: The RB protein: more than a sentry of cell cycle entry (Sung Lab)
May 1, 2025Pulari U. Thangavelu1,11 ∙ Cheng-Yu Lin1,11 ∙ Farzaneh Forouz2 ∙ Kozo Tanaka3 ∙ Eloïse Dray4,5,6 ∙ Pascal H.G. Duijf7,8,9,10 pascal.duijf@unisa.edu.au Highlights The retinoblastoma protein (RB) signal transduction pathway suppresses tumor development a …
Nature Communications: Epigenetic silencing of DNA sensing pathway by FOXM1 blocks stress ligand-dependent antitumor immunity and immune memory (Rao, Chen, Zheng, Sung Labs et al)
April 29, 2025Santosh Timilsina, Jian Yu Huang, Nourhan Abdelfattah, Daisy Medina, Deepika Singh, Shahad Abdulsahib, Panneerdoss Subbarayalu, Trong Phat Do, Prabhakar Pitta Venkata, Saif Nirzhor, Jack Prochnau, Mukund Bhandari, Siyuan Zheng, Yidong Chen, Gang Huang, …