Greehey CCRI News & Events Archive

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Science Advances: Predicting and characterizing a cancer dependency map of tumors with deep learning (Aune, Chen, Rao, Houghton & Zheng Labs)

August 24, 2021

Yu-Chiao Chiu1, Siyuan Zheng1,2, Li-Ju Wang1, View ORCID ProfileBrian S. Iskra1, View ORCID ProfileManjeet K. Rao1,3, Peter J. Houghton1,4, View ORCID ProfileYufei Huang5,6,* and View ORCID ProfileYidong Chen1,2,* Abstract Genome-wide loss-of-function …


BRCA2 Promotes Spontaneous Homologous Recombination In Vivo (Bishop)

August 9, 2021

Adam D. Brown, Scott Greenman, Alison B. Claybon, Alexander J. R. Bishop Simple Summary Inherited mutation of either BRCA1 or BRCA2 is associated with familial breast and ovarian cancer. As a tumor suppressor, BRCA2 functions to maintain genome stabili …


Neuro-Oncololgy Advances: The effects of palbociclib in combination with radiation in preclinical models of aggressive meningioma (Houghton)

August 4, 2021

Craig Horbinski, Guifa Xi, Yufen Wang, Rintaro Hashizume, Mahesh Gopalakrishnan, Joanna J Phillips, Peter Houghton, Charles D James, John A Kalapurakal Abstract Background Meningiomas are the most common tumor arising within the cranium of adults. Desp …


MSystems: Identification of a GrgA-Euo-HrcA Transcriptional Regulatory Network in Chlamydia (Lai Lab)

August 4, 2021

Wurihan Wurihan , Yi Zou, Alec M. Weber, Korri Weldon, Yehong Huang, Xiaofeng Bao, Chengsheng Zhu, Xiang Wu, Yaqun Wang, Zhao Lai, and Huizhou Fan  ABSTRACT Chlamydia trachomatis is an obligate intracellular bacterium whose unique developmental cycle c …


Science Advances: Regulation of telomere homeostasis and genomic stability in cancer by N6-adenosine methylation (m6A) (Rao & Zheng Labs)

July 29, 2021

View ORCID ProfileJi Hoon Lee1,†, View ORCID ProfileJuyeong Hong1,†, View ORCID ProfileZhao Zhang1,†, View ORCID ProfileBárbara de la Peña Avalos2,3, View ORCID ProfileCecilia J. Proietti4, View ORCID ProfileAgustina Roldán Deamicis4, View ORCID Profil …


Scientific Reports: A comprehensive meta-analysis and a case–control study give insights into genetic susceptibility of lung cancer and subgroups (Bishop Lab)

July 19, 2021

Debmalya Sengupta, Souradeep Banerjee, Pramiti Mukhopadhyay (Bishop Lab)  Ritabrata Mitra, Tamohan Chaudhuri, Abhijit Sarkar, Gautam Bhattacharjee, Somsubhra Nath, Susanta Roychoudhury, Samsiddhi Bhattacharjee & Mainak Sengupta Abstract Reports of …


eLife Sciences: Loss of MGA repression mediated by an atypical polycomb complex promotes tumor progression and invasiveness (Shiio Lab)

July 9, 2021

    Haritha Mathsyaraja,  Jonathen Catchpole,  Brian Freie,  Emily Eastwood,  Ekaterina Babaeva,  Michael Geuenich,  Pei Feng Cheng,  Jessica Ayers,  Ming Yu,  Nan Wu,  Sitapriya Moorthi,  Kumud R Poudel,  Amanda Koehne,  William Grady,  A Mc …


Cell Reports: NELL2-cdc42 signaling regulates BAF complexes and Ewing sarcoma cell growthNELL2-cdc42 signaling regulates BAF complexes and Ewing sarcoma cell growth (Shiio, Houghton)

July 8, 2021

Panneerselvam Jayabal1, Fuchun Zhou1, Xiufen Lei1, XiuyeMa1, Barron Blackman1, Susan T.Weintraub23, Peter J.Houghton134, YuzuruShiio1235 Highlights • The autocrine signaling mediated by NELL2 maintains Ewing sarcoma cell growth • NELL2 signaling inhibi …


Dr. Houghton Co-Authors MDPI paper, “Dihydroartemisinin Inhibits mTORC1 Signaling by Activating the AMPK Pathway in Rhabdomyosarcoma Tumor Cells

July 2, 2021

Authored by: Jun Luo, Yoshinobu Odaka, Zhu Huang, Bing Cheng, Wang Liu, Lin Li, Chaowei Shang, Chao Zhang, Yang Wu, Yan Luo, Shengyong Yang, Peter J. Houghton, Xiaofeng Guo, Shile Huang Abstract Dihydroartemisinin (DHA), an anti-malarial drug, has been …


Nature Communications: Structural basis of DNA synthesis opposite 8-oxoguanine by human PrimPol primase-polymerase (Gupta)

June 29, 2021

Yogesh Gupta PhD Olga Rechkoblit, Robert E. Johnson, Yogesh K. Gupta, Louise Prakash, Satya Prakash & Aneel K. Aggarwal Abstract PrimPol is a human DNA polymerase-primase that localizes to mitochondria and nucleus and bypasses the major oxidative l …