Greehey CCRI News & Events Archive
Journal of Biological Chemistry: The transcription factor Wilms tumor 1 confers resistance in myeloid leukemia cells against the proapoptotic therapeutic agent TRAIL (tumor necrosis factor α-related apoptosis-inducing ligand) by regulating the antiapoptotic protein Bcl-xL
September 21, 2012Hima Bansal 1, Theresea Seifert, Carlos Bachier, Manjeet Rao, Gail Tomlinson, Swaminathan Padmanabhan Iyer, Sanjay Bansal Abstract Tumor necrosis factor α-related apoptosis-inducing ligand (TRAIL) is considered a promising cancer therapeutic agent due …
Pediatric Blood & Cancer: Clinical, histologic, and genetic features of mesothelioma in a 7-year-old child
September 7, 2012Aaron Sugalski 1, Mary Davis, Latha Prasannan, Victor Saldivar, Jaclyn Y Hung, Gail E Tomlinson Abstract Malignant mesothelioma (MM) is a highly aggressive malignancy that is extremely rare in children. This case report documents a 7-year-old male with …
Journal of Clinical Investigation: ZEB1 drives prometastatic actin cytoskeletal remodeling by downregulating miR-34a expression
August 1, 2012Young-Ho Ahn,1 Don L. Gibbons,1,2 Deepavali Chakravarti,3 Chad J. Creighton,4 Zain H. Rizvi,1 Henry P. Adams,5 Alexander Pertsemlidis,6 Philip A. Gregory,7,8 Josephine A. Wright,7,8 Gregory J. Goodall,7,8,9 Elsa R. Flores,3 and Jonathan M. Kurie1 Abstr …
Cancer Epidemiology Biomarkers & Prevention: A nonsynonymous polymorphism in IRS1 modifies risk of developing breast and ovarian cancers in BRCA1 and ovarian cancer in BRCA2 mutation carriers
August 1, 2012Yuan C Ding 1, Lesley McGuffog, Sue Healey, Eitan Friedman, Yael Laitman, Shani- Paluch-Shimon, Bella Kaufman, SWE-BRCA; Annelie Liljegren, Annika Lindblom, Håkan Olsson, Ulf Kristoffersson, Marie Stenmark-Askmalm, Beatrice Melin, Susan M Domchek, Kath …
DNA Repair Protocols: Identification of Genes Required for Damage Survival Using a Cell-Based RNAi Screen Against the Drosophila Genome
July 23, 2012Abstract Exposure to DNA-damaging agents invokes biological responses necessary for damage recovery and cell survival. Despite the presence of intact DNA repair pathways, a lack of certain other biological pathways has been shown to sensitize cells to …
PLOS One: Androgen-Responsive MicroRNAs in Mouse Sertoli Cells
July 20, 2012Subbarayalu Panneerdoss, Yao-Fu Chang, Kalyan C. Buddavarapu, Hung-I Harry Chen, Gunapala Shetty, Huizhen Wang, Yidong Chen, T. Rajendra Kumar, Manjeet K. Rao Abstract Although decades of research have established that androgen is essential for sperma …
Pediatric Blood & Cancer: Genetics and epigenetics of hepatoblastoma
July 13, 2012Gail E Tomlinson 1, Roland Kappler Abstract A number of unique genetic features are observed in hepatoblastoma that has provided insights into the origins of hepatoblastoma. Hallmark cytogenetic changes in hepatoblastoma include the acquisition of addi …
IEEE: Evaluating Dynamic Effects of Copy Number Alterations on Gene Expression Using a Single Transcription Model
July 13, 2012Fang-Han Hsu; Erchin Serpedin; Yidong Chen; Edward R. Dougherty Abstract: DNA copy number alterations (CNAs) are known to be related to genetic diseases, including cancer. The unlimited transcription (UT) model, in which transcription occurs permissive …
Expert Opinion on Biological Therapy: microRNA regulation of cell viability and drug sensitivity in lung cancer
June 26, 2012Liqin Du , & Alexander Pertsemlidis Abstract Introduction:microRNAs (miRNAs) are 19 – 23 nucleotide long RNAs found in multiple organisms that regulate gene expression and have been shown to play important roles in tumorigenesis. In the context of …
Transnational Cancer Research: Chain-reaction, a model of gene expression dynamics
June 21, 2012Submitted May 21, 2012. Accepted for publication Jun 21, 2012. doi: 10.3978/j.issn.2218-676X.2012.06.01 One of the fundamental studies of transcription response to stimuli is to model the activation, repression of hundreds of genes, and their regulatio …