Greehey CCRI Archives
Atlas of Science: The position of the centromere is marked with ubiquitylation of CENP-A
January 30, 2018Chromosomes must segregate equally between daughter cells during cell division, and for proper chromosome segregation, spindle microtubules must attach to a single region of each chromosome, termed the “centromere,” in most eukaryotes. The kinetochore …
Journal of Biological Chemistry: Cohesin SA2 is a sequence-independent DNA-binding protein that recognizes DNA replication and repair intermediates
January 19, 2018Preston Countryman 1, Yanlin Fan 2, Aparna Gorthi 3 4, Hai Pan 1, Jack Strickland 1, Parminder Kaur 1, Xuechun Wang 5, Jiangguo Lin 1 6, Xiaoying Lei 2 7, Christian White 1, Changjiang You 8, Nicolas Wirth 9, Ingrid Tessmer 9, Jacob Piehler 8, Robert R …
Neuro-Oncology: Activation of WEE1 confers resistance to PI3K inhibition in glioblastoma
January 1, 2018Shaofang Wu, Shuzhen Wang, Feng Gao, Luyuan Li, Siyuan Zheng, W K Alfred Yung, Dimpy Koul Abstract Background Oncogenic activation of phosphatidylinositol-3 kinase (PI3K) signaling plays a pivotal role in the development of glioblastoma (GBM). However, …
ACS Journals: Addressing late effects and quality of life essential to improving survivorship care (Aune Lab)
December 14, 2017Abstract This news section offers Cancer readers timely information on events, public policy analysis, topical issues, and personalities. In this issue, we highlight efforts being made to improve cancer survivorship care and mitigate the late effects o …
Genome Biology: The 3′ end of the story: deciphering combinatorial interactions that control mRNA fate.
November 29, 2017Authors Penalva LOF Sanford JR Precise control of messenger RNA (mRNA) fate—its translation, stability, and localization—is required for accurate eukaryotic gene expression and is of fundamental importance to human health and disease. Initial efforts t …
Pediatric Blood & Cancer: Evaluation of patritumab with or without erlotinib in combination with standard cytotoxic agents against pediatric sarcoma xenograft models
October 28, 2017Abhik Bandyopadhyay 1, Edward Favours 1, Doris A Phelps 1, Vanessa Del Pozo 1, Samson Ghilu 1, Dias Kurmashev 1, Joel Michalek 2, Aron Trevino 2, Denis Guttridge 3, Cheryl London 4, Kenji Hirotani 5, Ling Zhang 5, Raushan T Kurmasheva 1, Peter J Hought …
BMC Genomics: Genome-wide identification of key modulators of gene-gene interaction networks in breast cancer
October 3, 2017Yu-Chiao Chiu, Li-Ju Wang, Tzu-Hung Hsiao, Eric Y. Chuang & Yidong Chen Abstract Background With the advances in high-throughput gene profiling technologies, a large volume of gene interaction maps has been constructed. A higher-level layer of gene …
BMC Bioinformatics: XBSeq2: a fast and accurate quantification of differential expression and differential polyadenylation
October 3, 2017Yuanhang Liu, Ping Wu, Jingqi Zhou, Teresa L. Johnson-Pais, Zhao Lai, Wasim H. Chowdhury, Ronald Rodriguez & Yidong Chen Abstract Background RNA sequencing (RNA-seq) is a high throughput technology that profiles gene expression in a genome-wide man …
Science Signaling: Evaluation of the selectivity and sensitivity of isoform- and mutation-specific RAS antibodies
September 26, 2017Andrew M. Waters1,2, Irem Ozkan-Dagliyan3, Angelina V. Vaseva1,4, View ORCID ProfileNicole Fer2, Leslie A. Strathern2, View ORCID ProfileG. Aaron Hobbs1, View ORCID ProfileBasile Tessier-Cloutier5, View ORCID ProfileWilliam K. Gillette2, View ORCID Pro …
JoVE: Genome-wide Analysis of HDAC Inhibitor-mediated Modulation of microRNAs and mRNAs in B Cells Induced to Undergo Class-switch DNA Recombination and Plasma Cell Differentiation
September 20, 2017Helia N Sanchez 1, Tian Shen 2, Dawn Garcia 3, Zhao Lai 3, Paolo Casali 1, Hong Zan 4 Abstract Antibody responses are accomplished through several critical B cell-intrinsic processes, including somatic hypermutation (SHM), class-switch DNA recombinatio …