Greehey CCRI Archives
Nature Communications: Cross-talk between miR-471-5p and autophagy component proteins regulates LC3-associated phagocytosis (LAP) of apoptotic germ cells
September 19, 2017Subbarayalu Panneerdoss, Suryavathi Viswanadhapalli, Nourhan Abdelfattah, Benjamin C. Onyeagucha, Santosh Timilsina, Tabrez A. Mohammad, Yidong Chen, Michael Drake, Kristiina Vuori, T. Rajendra Kumar & Manjeet K. Rao Abstract Phagocytic clearance o …
Oncotarget: Novel post-transcriptional and post-translational regulation of pro-apoptotic protein BOK and anti-apoptotic protein Mcl-1 determine the fate of breast cancer cells to survive or die
September 12, 2017Benjamin Onyeagucha1,2, Panneerdoss Subbarayalu1,2, Nourhan Abdelfattah1,2, Subapriya Rajamanickam1,2, Santosh Timilsina1,2, Rosa Guzman1, Carla Zeballos2, Vijay Eedunuri1,2, Sanjay Bansal1, Tabrez Mohammad2, Yidong Chen1,3, Ratna K. Vadlamudi4, and Ma …
Familial Cancer: Discovery of mutations in homologous recombination genes in African-American women with breast cancer
September 2, 2017Yuan Chun Ding 1, Aaron W Adamson 1, Linda Steele 1, Adam M Bailis 2, Esther M John 3 4, Gail Tomlinson 5 6, Susan L Neuhausen 7 Abstract African-American women are more likely to develop aggressive breast cancer at younger ages and experience poorer c …
Human Genetics: RNA processing as an alternative route to attack glioblastoma
September 1, 2017Fabiana Marcelino Meliso, Christopher G Hubert, Pedro A Favoretto Galante, Luiz O Penalva Genomic analyses have become an important tool to identify new avenues for therapy. This is especially true for cancer types with extremely poor outcomes since ou …
Human Genetics: From mechanisms to therapy: RNA processing’s impact on human genetics
September 1, 2017Authors Luiz O Penalva, Jeremy R Sanford Protein-coding genes defy the one gene-one enzyme paradigm, in part, through the process of alternative pre-mRNA splicing. This mode of gene regulation is critical for generating protein isoforms with specific f …
Journal of Clinical and Translational Science: 2337: Doxorubicin exposure in vitro stimulates ROS production and directly suppresses cardiac fibroblast proliferation
September 1, 2017Trevi A. Mancilla (a1) and Gregory J. Aune (a1) Trevi A. Mancilla and Gregory J. Aune Abstract OBJECTIVES/SPECIFIC AIMS: Our research strives to understand the pathophysiology of doxorubicin cardiotoxicity, focusing on the understudied nonmyocyte cardi …
Scientific Reports: A miR-SNP biomarker linked to an increased lung cancer survival by miRNA-mediated down-regulation of FZD4 expression and Wnt signaling
August 22, 2017Jing Lin, Roza Zandi, Ruping Shao, Jian Gu, Yuanqin Ye, Jing Wang, Yang Zhao, Alexander Pertsemlidis, Ignacio I. Wistuba, Xifeng Wu, Jack A. Roth & Lin Ji Abstract Through a new hypothesis-driven and microRNA-pathway-based SNP (miR-SNP) association …
Cell Cycle: SGT1-HSP90 complex is required for CENP-A deposition at centromeres
August 17, 2017Yohei Niikura,Risa Kitagawa,Hiroo Ogi &Katsumi Kitagawa ABSTRACT The centromere plays an essential role in accurate chromosome segregation, and defects in its function lead to aneuploidy and thus cancer. The centromere-specific histone H3 variant C …
CPRIT Grant: Recruitment of First-Time, Tenure-Track Faculty Members
August 16, 2017“Big Data” is a driving force in cancer research today. Sifting through the data from thousands of cancer genomes will help researchers understand what drives cancer, and help them make predictions about therapies that will be most beneficial to indivi …
Cancer Research: IGFBP7 Deletion Promotes Hepatocellular Carcinoma
August 1, 2017Maaged Akiel, Chunqing Guo, Xia Li, Devaraja Rajasekaran, Rachel G. Mendoza, Chadia L. Robertson, Nidhi Jariwala, Fang Yuan, Mark A. Subler, Jolene Windle, Dawn K. Garcia, Zhao Lai, Hung-I Harry Chen, Yidong Chen, Shah Giashuddin, Paul B. Fisher, Xiang …