Greehey CCRI News & Events Archive

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Cell Chemical Biology: MYC Regulation of D2HGDH and L2HGDH Influences the Epigenome and Epitranscriptome

May 1, 2020

ZhiJun Qiu 1, An-Ping Lin 1, Shoulei Jiang 1, Sara M Elkashef 1, Jamie Myers 1, Subramanya Srikantan 2, Binu Sasi 1, John Z Cao 3, Lucy A Godley 3, Dinesh Rakheja 4, Yingli Lyu 5, Siyuan Zheng 6, Muniswamy Madesh 2, Yuzuru Shiio 7, Patricia L M Dahia 1 …


MDPI Cancers Magazine – Reconstruction of Ewing Sarcoma Developmental Context from Mass-Scale Transcriptomics Reveals Characteristics of EWSR1-FLI1 Permissibility (Bishop Lab)

April 16, 2020

by  Henry E. Miller 1,2, Aparna Gorthi 1,2, Nicklas Bassani 2, Liesl A. Lawrence 1,2, Brian S. Iskra 1,2 and Alexander J. R. Bishop 1,2,* This study aims at defining the features of the cell of origin for Ewing sarcoma through comparative bioinformatic …


“Singing in the Mud”, Message from the Dean

April 13, 2020

Former UT Chancellor, retired Admiral, and retired Navy Seal William H. McRaven wrote a story in the Washington Post that is worth sharing widely- “For a would-be Navy SEAL, Hell Week is the worst week of the toughest military training in the world. It …


Familial Cancer: Highly aggressive thoracic desmoid tumors in adolescent siblings with fatal outcomes in an FAP kindred: a need for increased vigilance and intervention in at-risk AYAs

April 13, 2020

Mohamed M. Gad, Anne-Marie Langevin, Aaron J. Sugalski & Gail E. Tomlinson Abstract Desmoid tumors are a manifestation of familial adenomatous polyposis (FAP), associated with mutation of the APC gene. Although considered benign tumors, desmoids ca …


Pipette Gazette: Unknown Pathogenic Agents: When Common Decency Is Better Than Nothing (Aune Lab)

April 6, 2020

Originally Published, Pipette Gazette: By: Brian Iskra, The pandemic of COVID-19 is a challenging situation for every member of society; we all have our role to play in mitigating the mortality caused by the infection. Medical professionals are at the …


BMG Medical Genomics: Convolutional neural network models for cancer type prediction based on gene expression

April 3, 2020

Milad Mostavi, Yu-Chiao Chiu, Yufei Huang & Yidong Chen Abstract Background Precise prediction of cancer types is vital for cancer diagnosis and therapy. Through a predictive model, important cancer marker genes can be inferred. Several studies hav …


Pain Reports: Reliable approaches to extract high-integrity RNA from skin and other pertinent tissues used in pain research

March 27, 2020

Peter M LoCoco 1, Jacob T Boyd 1, Claudia M Espitia Olaya 2, Ashley R Furr 1, Dawn K Garcia 3, Korri S Weldon 3, Yi Zou 3, Erin Locke 1, Alejandro Tobon 4, Zhao Lai 3 5, Shivani B Ruparel 1, Nikita B Ruparel 1, Kenneth M Hargreaves 1 Abstract Introduct …


Katsumi Kitagawa, Pharm.D., PhD Awarded $1M NSF Grant

March 16, 2020

Overview: Centromeres are essential for chromosome segregation during mitosis. The kinetochore is the protein complex associated with the centromere. Dysfunction in centromeres causes chromosome instability and can result in aneuploidy. The overall goa …


bioRxiv : Assessing the Heterogeneity of Cardiac Non-myocytes and the Effect of Cell Culture with Integrative Single Cell Analysis

March 4, 2020

Abstract Cardiac non-myocytes comprise a diverse and crucial cell population in the heart that plays dynamic roles in cardiac wound healing and growth. Non-myocytes broadly fall into four cell types: endothelium, fibroblasts, leukocytes, and pericytes. …


Clinical Cancer Research: EGFR Amplification Induces Increased DNA Damage Response and Renders Selective Sensitivity to Talazoparib (PARP Inhibitor) in Glioblastoma

March 1, 2020

Shaofang Wu 1, Feng Gao 1, Siyuan Zheng 2, Chen Zhang 1, Emmanuel Martinez-Ledesma 1 3, Ravesanker Ezhilarasan 4, Jie Ding 1, Xiaolong Li 1, Ningping Feng 5, Asha Multani 6, Erik P Sulman 4, Roel G Verhaak 2, John F de Groot 1, Tim P Heffernan 5, W K A …


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