Greehey CCRI Archives
Cancer Research: M6A RNA Methylation Regulates Histone Ubiquitination to Support Cancer Growth and Progression (Gupta, Zheng, Houghton, Chen, and Rao Labs)
March 21, 2022Pooja Yadav; Panneerdoss Subbarayalu; Daisy Medina, Saif Nirzhor; Santosh Timilsina; Subapriya Rajamanickam; Vijay K. Eedunuri; Yogesh Gupta Siyuan Zheng Nourhan Abdelfattah Yufei Huang Ratna Vadlamudi Robert Hromas; Paul Meltzer Peter Houghton; Yidon …
Cell Death & Disease: Global profiling reveals common and distinct N6-methyladenosine (m6A) regulation of innate immune responses during bacterial and viral infections (Lai & Chen Labs)
March 15, 2022Jian Feng, Teng Zhang, Océane Sorel, Wen Meng, Xinquan Zhang, Zhao Lai, Weiming Yuan, Yidong Chen, Yufei Huang & Shou-Jiang Gao Abstract N6-methyladenosine (m6A) is a dynamic post-transcriptional RNA modification influencing all aspects of mRNA bio …
eLife: Signature-scoring methods developed for bulk samples are not adequate for cancer single-cell RNA sequencing data (Zheng, Chen, & Wang Labs)
March 7, 2022Nighat Noureen, Zhenqing Ye, Yidong Chen, Xiaojing Wang, Siyuan Zheng Abstract Quantifying the activity of gene expression signatures is common in analyses of single-cell RNA sequencing data. Methods originally developed for bulk samples are often …
Angelina Vaseva, PhD to Receive NCI Method to Extend Research in Time (MERIT)(R37) Award.
March 2, 2022Angelina Vaseva, PhDAssistant Professor,Department of Molecular Medicine,Greehey Children’s Cancer Research Institute Congratulations to Dr. Vaseva on being awarded an NCI Method to Extend Research in Time (MERIT)(R37) Award. NCI R37 award provides lon …
Non-Coding RNA, FibroDB: Expression Analysis of Protein-Coding and Long Non-Coding RNA Genes in Fibrosis (Bishop Lab)
February 25, 2022by Mirolyuba Ilieva 1ORCID,Henry E. Miller 2,3,4ORCID,Arav Agarwal 4,5,Gabriela K. Paulus 4,6,Jens Hedelund Madsen 1,Alexander J. R. Bishop 2,3,7ORCID,Sakari Kauppinen 1 and Shizuka Uchida 1,*ORCID Abstract Most long non-coding RNAs (lncRNAs) are expre …
Cancers: Global Genomic and Proteomic Analysis Identified Critical Pathways Modulated by Proto-Oncogene PELP1 in TNBC (Chen & Lai)
February 25, 2022by Zexuan Liu 1,2,†,Kristin A. Altwegg 1,3,†ORCID,Junhao Liu 1,2,Susan T. Weintraub 4,Yidong Chen 5,6,Zhao Lai 5,7,Gangadhara R. Sareddy 1,3,Suryavathi Viswanadhapalli 1,3,*ORCID and Ratna K. Vadlamudi 1,3,8,* Simple Summary The proto-oncogene PELP1 is …
Journal of Pediatric Hematology/Oncology: Extrarenal Anaplastic Wilms Tumor A Case Report With Genomic Analysis And Tumor Models (Kurmasheva & Houghton)
February 8, 2022Willis, Kelsi R. MS*; Sathe, Adwait A. PhD†; Xing, Chao PhD†,‡,§; Koduru, Prasad PhD*; Artunduaga, Maddy MD∥,¶; Butler, Erin B. MD#; Park, Jason Y. MD, PhD*,¶; Kurmasheva, Raushan T. PhD**,††; Houghton, Peter J. PhD**,††; Chen, Kenneth S. MD¶,#; Rakhej …
Brain, Behavior, & Immunity: Sex-dependent pain trajectories induced by prolactin require an inflammatory response for pain resolution (Lai Lab)
January 24, 2022Author links open overlay panelJenniferMecklenburga AndiWangzhouf Anahit H.Hovhannisyana PriscillaBarba-Escobedoa Sergey A.Sheinb YiZoud KorriWeldond ZhaoLaideVincentGoffing GregoryDussorf Alexei V.Tumanovb Theodore J.Pricef Armen N.Akopiana …
eLife: RNA binding to human METTL3-METTL14 restricts N6-deoxyadenosine methylation of DNA in vitro (Gupta Lab)
January 21, 2022Shan Qi, Javier Mota, Siu-Hong Chan, Johanna Villarreal, Nan Dai, Shailee Arya, Robert A Hromas, Manjeet K Rao, Ivan R Corrêa Jr Yogesh K Gupta Abstract Methyltransferase like-3 (METTL3) and METTL14 complex transfer a methyl group from S-aden …