Greehey CCRI Archives
eLife: RNA binding to human METTL3-METTL14 restricts N6-deoxyadenosine methylation of DNA in vitro (Gupta Lab)
January 21, 2022Shan Qi, Javier Mota, Siu-Hong Chan, Johanna Villarreal, Nan Dai, Shailee Arya, Robert A Hromas, Manjeet K Rao, Ivan R Corrêa Jr Yogesh K Gupta Abstract Methyltransferase like-3 (METTL3) and METTL14 complex transfer a methyl group from S-aden …
Frontiers in Microbiology: Robust Heat Shock Response in Chlamydia Lacking a Typical Heat Shock Sigma Factor (Lai Lab)
January 20, 2022Yehong Huang1,2†, Wurihan Wurihan2†, Bin Lu1,2†, Yi Zou3, Yuxuan Wang2†, Korri Weldon3, Joseph D. Fondell2†, Zhao Lai3,4, Xiang Wu1*†, and Huizhou Fan2*† Cells reprogram their transcriptome in response to stress, such as heat shock. In free-living bact …
Frontiers in Genetics: Differential lncRNA/mRNA Expression Profiling and Functional Network Analyses in Bmp2 Deletion of Mouse Dental Papilla Cells (Lai Lab)
January 20, 2022Feng Wang1,2†, Ran Tao1†, Li Zhao1, Xin-Hui Hao1, Yi Zou3, Qing Lin1, Meng Meng Liu2, Graham Goldman2, Daoshu Luo1* and Shuo Chen2* Bmp2 is essential for dentin development and formation. Bmp2 conditional knock-out (KO) mice display a similar tooth phe …
iScience: SARS-CoV-2 infection enhances mitochondrial PTP complex activity to perturb cardiac energetics (Aune)
January 19, 2022Karthik Ramachandran110 Soumya Maity110 Alagar R.Muthukumar2 Soundarya Kandala1 Dhanendra Tomar3 Tarek Mohamed Abd El-Aziz49 Cristel Allen1 Yuyang Sun5 Manigandan Venkatesan1 Travis R.Madaris1 Kevin Chiem6 RachelTruitt7 Neelanjan Vishnu1 G …
Urologic Oncology: Prevalence of pathogenic germline cancer risk variants in testicular cancer patients: Identifying high risk groups (Tomlinson)
January 19, 2022ChethanRamamurthyM.D.a‡Amin H.NassarM.D.bc‡SarahAbou AlaiwiM.D.bcElioAdibM.D.bcElie W.AklM.D.cShanYangPh.D.dEdward D.EsplinM.D., Ph.D.dMichael A.LissM.D.aGail E.TomlinsonM.D.eGuru P.SonpavdeM.D.b Highlights • Testicular cancer patients are at risk for …
iScience: PEGylated talazoparib enhances therapeutic window of its combination with temozolomide in Ewing sarcoma (Kurmasheva & Houghton Labs)
January 18, 2022Vanessa del Pozo Andrew J.Robles Shaun D.Fontaine QianqianLiu Joel E.Michalek Peter J.Houghton Raushan T.Kurmasheva Highlights Nanoparticle-formulated drugs minimize drug-induced toxicity PEG∼TLZ enhances in vivo activity of TMZ in pediatric tumor xeno …
Cellular Oncology: Single-cell RNA profiling identifies diverse cellular responses to EWSR1/FLI1 down regulation in Ewing sarcoma cells (Houghton, Chen, Kitagawa, Ignatius)
January 12, 2022Roxane Khoogar, Fuyang Li, Yidong Chen, Myron Ignatius, Elizabeth R. Lawlor, Katsumi Kitagawa, Tim H.-M. Huang, Doris A. Phelps & Peter J. Houghton Background The EWSR1/FLI1 gene fusion is the most common rearrangement leading to cell transformatio …
Genes & Cancer: EZH2 suppresses endogenous retroviruses and an interferon response in cancers (Shiio Lab)
January 10, 2022Panneerselvam Jayabal1, Xiuye Ma1 and Yuzuru Shiio1,2,3 ABSTRACT Ewing sarcoma is an aggressive cancer of the bone and soft tissue in children. It is characterized by the chromosomal translocation between EWS and an Ets family transcription factor, mos …
PMC: The Role of Hedgehog Pathway in Uterine Leiomyosarcoma (Houghton Lab)
January 7, 2022Natalia Garcia,1 Mara Ulin,2 Ayman Al-Hendy,3 and Qiwei Yang3 DESCRIPTION The uterine Leiomyosarcoma (LMS) represents 3%-7% of all uterine cancers. This rare tumor has an annual incidence of 0.8 per 100,00 women. Unfortunately, LMS is well known for it …
MDPI: Altertoxin II, a Highly Effective and Specific Compound against Ewing Sarcoma (Houghton Lab)
January 6, 2022Andrew J. Robles Wentao Dai Saikat Haldar Hongyan Ma Victoria M. Anderson Ross D. Overacker April L. Risinger, Sandra Loesgen Peter J. Houghton Robert H. Cichewicz Susan L. Mooberry Simple Summary Ewing sarcoma is a cancer of the bone and soft tissues …