Cell Reports: EWSR1::FLI1 promotes neocentromere formation in Ewing sarcoma cells (Kitagawa, Zheng, & Sung Labs)
September 30, 2026EWSR1::FLI1 promotes neocentromere formation in ewing sarcoma cells Risa Kitagawa1,2 ∙ Ediri E. Metitiri1,2 ∙ Bin Yu1,2 ∙ Changxian Shen1,2,6 ∙ Alexander J.R. Bishop1,3,5 ∙ Siyuan Zheng1,4 ∙ Peter J. Houghton1,2 ∙ Katsumi Kitagawa1,2,7 Highlights • EW …
Childhood Cancer Awareness Month: THE SCIENCE BEHIND THE GOLD RIBBON: THE KITAGAWA LAB 🎗️
September 8, 2026Cancer cells are notorious rule-breakers. Sometimes, they even end up with the wrong number of chromosomes. At the Greehey Children’s Cancer Research Institute, the Kitagawa Lab, led by Katsumi Kitagawa, Pharm.D., PhD, is investigating how mistakes inv …
Cell Reports: EWSR1::FLI1 promotes neocentromere formation in Ewing sarcoma cells (Zheng, Sung Lab, Kitagawa Lab)
August 17, 2026Risa Kitagawa1,2 ∙ Ediri E. Metitiri1,2 ∙ Bin Yu1,2 ∙ Changxian Shen1,2,6 ∙ Alexander J.R. Bishop1,3,5 ∙ Siyuan Zheng1,4 ∙ Peter J. Houghton1,2 ∙ Katsumi Kitagawa1,2,7 Send email to kitagawak@uthscsa.edu Highlights Summary Ewing sarcoma (EwS) is charac …
Scientific Reports: A CIC-related-epigenetic factors-based model associated with prediction, the tumor microenvironment and drug sensitivity in osteosarcoma (Kitagawa Lab)
January 16, 2024Bin Yu, Chengkui Geng, Zhongxiong Wu, Zhongzi Zhang, Aili Zhang, Ze Yang, Jiazheng Huang, Ying Xiong, Huiqin Yang & Zhuoyuan Chen Abstract Osteosarcoma is generally considered a cold tumor and is characterized by epigenetic alterations. Although tu …
Katsumi Kitagawa, Pharm.D., PhD, to Receive NIH Grant to study “The Role of EWSR1 at the Centromere.”
June 16, 2023Abstract Text The centromere is a unique chromosomal region that is essential for high-fidelity chromosome transmission during cell division. In mitosis, microtubules attached to the kinetochore help ensure the faithful segregation of sister chromatids …
Cell Reports: EWSR1 Maintains Centromere Identity (Kitagawa & Houghton labs)
May 30, 2023Risa Kitagawa 1, Yohei Niikura 1 2, Argentina Becker 1 3, Peter J. Houghton 1, Katsumi Kitagawa 1 4 Highlights EWSR1 is required to maintain CENP-A at the centromere in interphase cells EWSR1 binds to CENP-A through the SYGQ2 region, important for phas …
Cellular Oncology: Single-cell RNA profiling identifies diverse cellular responses to EWSR1/FLI1 down regulation in Ewing sarcoma cells (Houghton, Chen, Kitagawa, Ignatius)
January 12, 2022Roxane Khoogar, Fuyang Li, Yidong Chen, Myron Ignatius, Elizabeth R. Lawlor, Katsumi Kitagawa, Tim H.-M. Huang, Doris A. Phelps & Peter J. Houghton Background The EWSR1/FLI1 gene fusion is the most common rearrangement leading to cell transformatio …
Please welcome the Greehey CCRI summer 2021 interns
June 7, 2021*not all summer program students pictured Greehey CCRI would like to welcome the 2021 Donald G McEwen, Memorial Summer Undergraduate Research Program students. Gaby Ruban – Dr. Chen …
Frontiers in Molecular Biosciences: The Role of Human Centromeric RNA in Chromosome StabilityThe Role of Human Centromeric RNA in Chromosome Stability (Kitagawa Lab)
April 20, 2021Introduction Accurate chromosome segregation is fundamental for cell division. Errors in this process can lead to chromosome instability, leading to aneuploidy, which is correlated with cancer (Zhu et al., 2011; Santaguida and Amon, 2015). The centrome …
Jove: Mass Spectrometry Analysis to Identify Ubiquitylation of EYFP-tagged CENP-A (EYFP-CENP-A)
June 10, 2020Yohei Niikura*1, Lei Fang*2, Risa Kitagawa*3, Peizhao Li1, Yao Xi1, Ju You1, Yan Guo2, Katsumi Kitagawa3 Summary CENP-A ubiquitylation is an important requirement for CENP-A deposition at the centromere, inherited through dimerization between cell divi …
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