Greehey CCRI News & Events Archive
Cell Cycle: SGT1-HSP90 complex is required for CENP-A deposition at centromeres
August 17, 2017Yohei Niikura,Risa Kitagawa,Hiroo Ogi &Katsumi Kitagawa ABSTRACT The centromere plays an essential role in accurate chromosome segregation, and defects in its function lead to aneuploidy and thus cancer. The centromere-specific histone H3 variant C …
Developmental Cell: CENP-A Ubiquitylation Is Required for CENP-A Deposition at the Centromere
December 20, 2016YoheiNiikura1, RisaKitagawa1, KatsumiKitagawa1 Main Text CENP-A is a centromere-specific histone variant that determines centromere identity, but how it localizes to centromeres is not completely understood. Previously, we demonstrated that CENP-A depo …
Molecular & Cellular Oncology: The inheritance of centromere identity
June 30, 2016Yohei Niikura,Risa Kitagawa & Katsumi Kitagawa ABSTRACT CENP-A (Centromere protein A) is a histone H3 variant that epigenetically determines the centromere position, but the mechanism of its centromere inheritance is obscure. We propose that CENP-A …
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