Greehey CCRI Archives

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Atlas of Science: The position of the centromere is marked with ubiquitylation of CENP-A

January 30, 2018

Chromosomes must segregate equally between daughter cells during cell division, and for proper chromosome segregation, spindle microtubules must attach to a single region of each chromosome, termed the “centromere,” in most eukaryotes. The kinetochore …


UT Health SA Newsroom: Greehey Institute begins 2018 with new faculty studying children’s cancer

January 18, 2018

The Greehey Children’s Cancer Research Institute at UT Health San Antonio is on an impressive and rising trajectory as 2018 begins. This includes the recruitment of seven new faculty members, further bolstering the Alamo City’s thriving biosciences sec …


Cell Cycle: SGT1-HSP90 complex is required for CENP-A deposition at centromeres

August 17, 2017

Yohei Niikura,Risa Kitagawa,Hiroo Ogi &Katsumi Kitagawa ABSTRACT The centromere plays an essential role in accurate chromosome segregation, and defects in its function lead to aneuploidy and thus cancer. The centromere-specific histone H3 variant C …


Developmental Cell: CENP-A Ubiquitylation Is Required for CENP-A Deposition at the Centromere

December 20, 2016

YoheiNiikura1, RisaKitagawa1, KatsumiKitagawa1 Main Text CENP-A is a centromere-specific histone variant that determines centromere identity, but how it localizes to centromeres is not completely understood. Previously, we demonstrated that CENP-A depo …


Molecular & Cellular Oncology: The inheritance of centromere identity

June 30, 2016

Yohei Niikura,Risa Kitagawa & Katsumi Kitagawa ABSTRACT CENP-A (Centromere protein A) is a histone H3 variant that epigenetically determines the centromere position, but the mechanism of its centromere inheritance is obscure. We propose that CENP-A …