Greehey CCRI Archives

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Cancer Research: Deciphering the role of intestinal crypt cell populations in resistance to chemotherapy (Penalva Lab)

March 30, 2021

Carla Frau, Catherine Jamard, Gaspard Delpouve, Gabriela D. A. Guardia, Christelle Machon, Camilla Pilati, Clementine Le Neve, Pierre Laurent-Puig, Jérôme Guitton, Pedro A. F. Galante, Luiz O. Penalva, Jean-Noel Freund, Christelle de la Fouchardière an …


Development: The murine intestinal stem cells are highly sensitive to the modulation of the T3/TRα1-dependent pathway (Penalva Lab)

March 30, 2021

Matthias Godart, Carla Frau, Diana Farhat, Maria Virginia Giolito, Catherine Jamard, Clementine Le Nevé, Jean-Noel Freund, Luiz O. Penalva, Maria Sirakov, Michelina Plateroti Abstract The thyroid hormone T3 and its nuclear receptor TRα1 control gut dev …


MDPI: Musashi1 Contribution to Glioblastoma Development via Regulation of a Network of DNA Replication, Cell Cycle and Division Genes (Penalva Lab)

March 30, 2021

Mirella Baroni 1,†,  OrcID,Caihong Yi 1,2,†,  Saket Choudhary 3,†,  Xiufen Lei 1,  Adam Kosti 1,4,   Denise Grieshober 1,  Mitzli Velasco 1,  Mei Qiao 1,  Suzanne S. Burns 1,‡,  Patricia R. Araujo 1,  Talia DeLambre 1,  Mi Young Son 5,  Michelina Plate …


MDPI: Synergism of Proneurogenic miRNAs Provides a More Effective Strategy to Target Glioma Stem Cells (Penalva & Pertsemlidis Labs)

January 14, 2021

Adam Kosti, Rodrigo Barreiro, Gabriela D. A. Guardia, Shiva Ostadrahimi, Erzsebet Kokovay, Alexander Pertsemlidis, Pedro A. F. Galante, Luiz O. F. Penalva Simple Summary miRNAs function as critical regulators of gene expression and have been defined as …


MDPI: MSI1 Promotes the Expression of the GBM Stem Cell Marker CD44 by Impairing miRNA-Dependent Degradation

December 5, 2020

Rebecca Pötschke  1,2,† Jacob Haase 1,†,  Markus Glaß 1  Sebastian Simmermacher  3,Claudia Misiak 1,Luiz O. F. Penalva 4,5  Caspar D. Kühnöl, 2 and Stefan Hüttelmaier  1, Simple Summary Glioblastoma (GBM) is the most lethal brain tumor with a median su …


Luiz O.F. Penalva PhD Awarded CPRIT Grant to Study New Glioblastoma (GBM) Regulator

August 20, 2020

PROJECT SUMMARY Glioblastoma (GBM) is the most common and most aggressive brain tumor type among adults with a 14 months average patient survival. Despite all genomic efforts in recent years, novel therapies based on GBM common mutations and alteration …


Genome Biology: The RNA-binding protein SERBP1 functions as a novel oncogenic factor in glioblastoma by bridging cancer metabolism and epigenetic regulation.

August 20, 2020

Background RNA-binding proteins (RBPs) function as master regulators of gene expression. Alterations in RBP expression and function are often observed in cancer and influence critical pathways implicated in tumor initiation and growth. Identification a …


Luiz O.F. Penalva PhD Awarded CPRIT Grant to Study Glioblastoma (GBM)

August 20, 2020

PROJECT SUMMARY Glioblastoma (GBM) is the most common and most aggressive brain tumor type among adults with a 14 months average patient survival. Despite all genomic efforts in recent years, novel therapies based on GBM common mutations and alteration …


Genome Biology: The RNA-binding protein SERBP1 functions as a novel oncogenic factor in glioblastoma by bridging cancer metabolism and epigenetic regulation (Bishop & Penalva Labs)

August 6, 2020

Adam Kosti 1 2, Patricia Rosa de Araujo 1 2, Wei-Qing Li 1 3, Gabriela D A Guardia 4, Jennifer Chiou 5, Caihong Yi 1, Debashish Ray 6, Fabiana Meliso 4, Yi-Ming Li 3, Talia Delambre 1, Mei Qiao 1, Suzanne S Burns 1, Franziska K Lorbeer 1, Fanny Georgi  …


Prof. Luiz O.F. Penalva, PhD

Luiz O.F. Penalva, PhD, Co-corresponding Senior Author on NPJ Genomic Medicine publication.

“Proneural and mesenchymal glioma stem cells display major differences in splicing and lncRNA profiles” Abstract Therapy resistance and recurrence in high-grade gliomas are driven by their populations of glioma stem cells (GSCs). Thus, detailed molecul …