Greehey CCRI News & Events Archive

Filter results


 

MDPI: MSI1 Promotes the Expression of the GBM Stem Cell Marker CD44 by Impairing miRNA-Dependent Degradation

December 5, 2020

Rebecca Pötschke  1,2,† Jacob Haase 1,†,  Markus Glaß 1  Sebastian Simmermacher  3,Claudia Misiak 1,Luiz O. F. Penalva 4,5  Caspar D. Kühnöl, 2 and Stefan Hüttelmaier  1, Simple Summary Glioblastoma (GBM) is the most lethal brain tumor with a median su …


Luiz O.F. Penalva PhD Awarded CPRIT Grant to Study New Glioblastoma (GBM) Regulator

August 20, 2020

PROJECT SUMMARY Glioblastoma (GBM) is the most common and most aggressive brain tumor type among adults with a 14 months average patient survival. Despite all genomic efforts in recent years, novel therapies based on GBM common mutations and alteration …


Genome Biology: The RNA-binding protein SERBP1 functions as a novel oncogenic factor in glioblastoma by bridging cancer metabolism and epigenetic regulation.

August 20, 2020

Background RNA-binding proteins (RBPs) function as master regulators of gene expression. Alterations in RBP expression and function are often observed in cancer and influence critical pathways implicated in tumor initiation and growth. Identification a …


Luiz O.F. Penalva PhD Awarded CPRIT Grant to Study Glioblastoma (GBM)

August 20, 2020

PROJECT SUMMARY Glioblastoma (GBM) is the most common and most aggressive brain tumor type among adults with a 14 months average patient survival. Despite all genomic efforts in recent years, novel therapies based on GBM common mutations and alteration …


Genome Biology: The RNA-binding protein SERBP1 functions as a novel oncogenic factor in glioblastoma by bridging cancer metabolism and epigenetic regulation (Bishop & Penalva Labs)

August 6, 2020

Adam Kosti 1 2, Patricia Rosa de Araujo 1 2, Wei-Qing Li 1 3, Gabriela D A Guardia 4, Jennifer Chiou 5, Caihong Yi 1, Debashish Ray 6, Fabiana Meliso 4, Yi-Ming Li 3, Talia Delambre 1, Mei Qiao 1, Suzanne S Burns 1, Franziska K Lorbeer 1, Fanny Georgi  …


Prof. Luiz O.F. Penalva, PhD

Luiz O.F. Penalva, PhD, Co-corresponding Senior Author on NPJ Genomic Medicine publication.

“Proneural and mesenchymal glioma stem cells display major differences in splicing and lncRNA profiles” Abstract Therapy resistance and recurrence in high-grade gliomas are driven by their populations of glioma stem cells (GSCs). Thus, detailed molecul …


Cell Stem Cell: Zika virus targets glioblastoma stem cells through a SOX2-integrin αvβ5 axis

February 6, 2020

Zhe Zhu, Pinar Mesci, Jean A Bernatchez, Ryan C Gimple, Xiuxing Wang, Simon T Schafer, Hiromi I Wettersten, Sungjun Beck, Alex E Clark, Qiulian Wu, Briana C Prager, Leo JY Kim, Rekha Dhanwani, Sonia Sharma, Alexandra Garancher, Sara M Weis, Stephen C M …


Adam Kosti Publishes First, First-Author Paper (Penalva Lab)

January 10, 2020

ELF4 is a Target of miR-124 and Promotes Neuroblastoma Proliferation and Undifferentiated State Abstract 13-Cis-retinoic acid (RA) is typically used in postremission maintenance therapy in patients with neuroblastoma. However, side effects and recurren …


Molecular Cancer Research: ELF4 is a target of miR-124 and promotes neuroblastoma proliferation and undifferentiated state

January 1, 2020

Adam Kosti, Liqin Du, Haridha Shivram, Mei Qiao, Suzanne Burns, Juan Gabriel Garcia, Alexander Pertsemlidis, Vishwanath R Iyer, Erzsebet Kokovay, Luiz OF Penalva 13-Cis-retinoic acid (RA) is typically used in postremission maintenance therapy in patien …


Scientific Reports: Genomic analyses of early responses to radiation in glioblastoma reveal new alterations at transcription, splicing, and translation levels

January 1, 2020

Choudhary Saket, Suzanne C Burns, Mirsafian Hoda, Wenzheng Li, Dat T Vo, Qiao Mei, Lei Xiufen, Andrew D Smith, Luiz O Penalva High-dose radiation is the main component of glioblastoma therapy. Unfortunately, radio-resistance is a common problem and a m …