Greehey CCRI Archives
Aging Cell: mTOR drives cerebrovascular, synaptic, and cognitive dysfunction in normative aging
November 6, 2019Candice E. Van Skike, Ai‐Ling Lin, Raquel Roberts Burbank, Jonathan J. Halloran, Stephen F. Hernandez, James Cuvillier, Vanessa Y. Soto, Stacy A. Hussong, Jordan B. Jahrling, Martin A. Javors, Matthew J. Hart, Kathleen E. Fischer, Steven N. Austad, Ver …
Bioorganic & Medicinal Chemistry: Synthesis and SAR of novel capsazepine analogs with significant anti-cancer effects in multiple cancer types
June 1, 2019JorgeDe La Chapaa, Matthew Valdezb, Franscisco RuizIIIb, Keith Gonzalesb, Wes Mitchellb, Stanton F.McHardybc, Matthew Hartbc, Srikanth R.Polusanib, Cara B.Gonzalesac Abstract We previously demonstrated that capsazepine (CPZ), a synthetic transient rece …
Journal of Oral Pathology & Medicine: The novel capsazepine analog, CIDD‐99, significantly inhibits oral squamous cell carcinoma in vivo through a TRPV1‐independent induction of ER stress, mitochondrial dysfunction, and apoptosis
February 3, 2019Jorge J. De La Chapa, Prajjal K. Singha, Kristen K. Self, McKay L. Sallaway, Stanton F. McHardy, Matthew J. Hart, Howard Stan McGuff, Matthew C. Valdez Francisco Ruiz II, Srikanth R. Polusani, Cara B. Gonzales Abstract Background Oral squamous cell car …
RNA Biology: Luteolin inhibits Musashi1 binding to RNA and disrupts cancer phenotypes in glioblastoma cells
November 18, 2018Caihong Yi,Guiming Li,Dmitri N. Ivanov,Zhonghua Wang,Mitzli X. Velasco,Greco Hernández,Soni Kaundal,Johanna Villarreal,Yogesh K. Gupta ,Mei Qiao,Christopher G. Hubert,Matthew J. Hart &Luiz O.F. Penalva ABSTRACT RNA binding proteins have emerged as …
International Journal of Oncology: Novel polygodial analogs P3 and P27: Efficacious therapeutic agents disrupting mitochondrial function in oral squamous cell carcinoma
October 5, 2018Jorge De La Chapa, Prajjal Kanti Singha, Mckay Sallaway, Kristen Self, Ranna Nasreldin, Ramesh Dasari, Matthew Hart., Alexander Kornienko, Jeremy Just, Jason A. Smith, Alex C. Bissember, Cara B. Gonzales Abstract Polygodial, a drimane sesquiterpenoid …
Cell: Inborn Errors of RNA Lariat Metabolism in Humans with Brainstem Viral Infection
February 22, 2018Author links open overlay panelShen-YingZhang12339, Nathaniel E.Clark436, Catherine A.Freije536, Elodie Pauwels136Allison J.Taggart636, SatoshiOkada737, Hanna Mandel8937, PaulaGarcia1037, Michael J.Ciancanelli137, Anat Biran137, Fabien G.Lafaille137, M …
Journal of Biological Chemistry: An engineered transforming growth factor β (TGF-β) monomer that functions as a dominant negative to block TGF-β signaling
February 22, 2017Sun Kyung Kim‡1, Lindsey Barron§, Cynthia S. Hinck¶, Elyse M. Petrunak¶, Kristin E. Cano‡, Avinash Thangirala‡, Brian Iskra‡, Molly Brothers‡, Machell Vonberg‡, Belinda Leal‡, Blair Richter‡, Ravindra Kodali¶, Alexander B. Taylor‡, Shoucheng Du¶, Chris …
UT Health SA Newsroom: Health Science Center, UTSA gain $4.6 million for cancer research
August 25, 2016The Center for Innovative Drug Discovery (CIDD), a joint program of the UT Health Science Center San Antonio and The University of Texas at San Antonio (UTSA), is receiving a $4,598,728 grant from the Cancer Prevention & Research Institute of Texas …
Biochimica et Biophysica Acta (BBA) – Molecular Basis of Disease: Vascular mTOR-dependent mechanisms linking the control of aging to Alzheimer’s disease
May 1, 2016Abstract Aging is the strongest known risk factor for Alzheimer’s disease (AD). With the discovery of the mechanistic target of rapamycin (mTOR) as a critical pathway controlling the rate of aging in mice, molecules at the interface between the regulat …
Pathobiology of Aging & Age-related Diseases: Rapamycin improves motor function, reduces 4-hydroxynonenal adducted protein in brain, and attenuates synaptic injury in a mouse model of synucleinopathy
August 24, 2015Xiang Bai, Margaret Chia-Ying Wey, Elizabeth Fernandez, Matthew J. Hart, Jonathan Gelfond, Alex F. Bokov, Sheela Rani & Randy Strong Abstract Background Synucleinopathy is any of a group of age-related neurodegenerative disorders including Parkinso …