Greehey CCRI News & Events Archive

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APPLICATIONS NOW BEING ACCEPTED: Greehey CCRI Donald G McEwen, Memorial Summer 2021 Undergraduate Research Program

April 6, 2021

Applications are now being accepted for the Greehey CCRI Undergraduate Summer Internship Program.   The purpose of the Greehey CCRI Undergraduate Summer Internship Program is to allow talented undergraduate students interested in a career in academic r …


Aging Cell: mTOR drives cerebrovascular, synaptic, and cognitive dysfunction in normative aging

November 6, 2019

Candice E. Van Skike, Ai‐Ling Lin, Raquel Roberts Burbank, Jonathan J. Halloran, Stephen F. Hernandez, James Cuvillier, Vanessa Y. Soto, Stacy A. Hussong, Jordan B. Jahrling, Martin A. Javors, Matthew J. Hart, Kathleen E. Fischer, Steven N. Austad, Ver …


Bioorganic & Medicinal Chemistry: Synthesis and SAR of novel capsazepine analogs with significant anti-cancer effects in multiple cancer types

June 1, 2019

JorgeDe La Chapaa, Matthew Valdezb, Franscisco RuizIIIb, Keith Gonzalesb, Wes Mitchellb, Stanton F.McHardybc, Matthew Hartbc, Srikanth R.Polusanib, Cara B.Gonzalesac Abstract We previously demonstrated that capsazepine (CPZ), a synthetic transient rece …


Journal of Oral Pathology & Medicine: The novel capsazepine analog, CIDD‐99, significantly inhibits oral squamous cell carcinoma in vivo through a TRPV1‐independent induction of ER stress, mitochondrial dysfunction, and apoptosis

February 3, 2019

Jorge J. De La Chapa, Prajjal K. Singha, Kristen K. Self, McKay L. Sallaway, Stanton F. McHardy, Matthew J. Hart, Howard Stan McGuff, Matthew C. Valdez Francisco Ruiz II, Srikanth R. Polusani, Cara B. Gonzales Abstract Background Oral squamous cell car …


RNA Biology: Luteolin inhibits Musashi1 binding to RNA and disrupts cancer phenotypes in glioblastoma cells

November 18, 2018

Caihong Yi,Guiming Li,Dmitri N. Ivanov,Zhonghua Wang,Mitzli X. Velasco,Greco Hernández,Soni Kaundal,Johanna Villarreal,Yogesh K. Gupta  ,Mei Qiao,Christopher G. Hubert,Matthew J. Hart &Luiz O.F. Penalva ABSTRACT RNA binding proteins have emerged as …


International Journal of Oncology: Novel polygodial analogs P3 and P27: Efficacious therapeutic agents disrupting mitochondrial function in oral squamous cell carcinoma

October 5, 2018

Jorge De La Chapa, Prajjal Kanti Singha, Mckay Sallaway, Kristen Self, Ranna  Nasreldin, Ramesh Dasari, Matthew Hart., Alexander Kornienko, Jeremy  Just, Jason A. Smith, Alex C. Bissember, Cara B. Gonzales Abstract Polygodial, a drimane sesquiterpenoid …


Cell: Inborn Errors of RNA Lariat Metabolism in Humans with Brainstem Viral Infection

February 22, 2018

Author links open overlay panelShen-YingZhang12339, Nathaniel E.Clark436, Catherine A.Freije536, Elodie Pauwels136Allison J.Taggart636, SatoshiOkada737, Hanna Mandel8937, PaulaGarcia1037, Michael J.Ciancanelli137, Anat Biran137, Fabien G.Lafaille137, M …


Journal of Biological Chemistry: An engineered transforming growth factor β (TGF-β) monomer that functions as a dominant negative to block TGF-β signaling

February 22, 2017

Sun Kyung Kim‡1, Lindsey Barron§, Cynthia S. Hinck¶, Elyse M. Petrunak¶, Kristin E. Cano‡, Avinash Thangirala‡, Brian Iskra‡, Molly Brothers‡, Machell Vonberg‡, Belinda Leal‡, Blair Richter‡, Ravindra Kodali¶, Alexander B. Taylor‡, Shoucheng Du¶, Chris …


UT Health SA Newsroom: Health Science Center, UTSA gain $4.6 million for cancer research

August 25, 2016

The Center for Innovative Drug Discovery (CIDD), a joint program of the UT Health Science Center San Antonio and The University of Texas at San Antonio (UTSA), is receiving a $4,598,728 grant from the Cancer Prevention & Research Institute of Texas …


Biochimica et Biophysica Acta (BBA) – Molecular Basis of Disease: Vascular mTOR-dependent mechanisms linking the control of aging to Alzheimer’s disease

May 1, 2016

Abstract Aging is the strongest known risk factor for Alzheimer’s disease (AD). With the discovery of the mechanistic target of rapamycin (mTOR) as a critical pathway controlling the rate of aging in mice, molecules at the interface between the regulat …


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