Editorial: Efficacy of larotrectinib in pediatric cancers with NTRK gene fusions (Houghton)
December 31, 2025Peter J Houghton 1, Mary-Ann Bjornsti 2 PMID: 41502892 PMCID: PMC12771222 DOI: 10.21037/tp-2025-664 No abstract available Figures Figure 1 Signaling pathways downstream of ligand… Figure 2 Schema showing characteristics of fusion… Comment on Elective D …
Cell Reports: IGSF10 is a RET antagonist regulating Ewing sarcoma growth and GnRH neuron migration (Chen, Houghton, & Shiio Lab)
July 24, 2025Panneerselvam Jayabal1 ∙ Xiuye Ma1 ∙ Maleeha Akram2 ∙ Hannah Bow2 ∙ Pranay Mandal2 ∙ Naira Mansano2 ∙ Yidong Chen1,3,4 ∙ Susan T. Weintraub4,5 ∙ Peter J. Houghton1,4,6 ∙ Susan Wray2 ∙ Yuzuru Shiio Highlights Ewing sarcoma depends on IGSF10, which inhib …
Neuro-Oncology: Dual inhibition of MAPK and TORC1 signaling retards development of radiation resistance in pediatric BRAFV600E glioma models (Chen Lab, Zheng, Houghton)
July 1, 2025Fuyang Li , Kathryn M Bondra , Hanzhou Wang , Dias Kurmashev , Bipasha Mukherjee , Suman Kanji , Amyn A Habib , Yidong Chen , Siyuan Zheng , Sandeep Burma , Peter J Houghton Abstract Background MAPK pathway inhibitors (MAPKi) have shown signi …
NPJ – Precision Oncology: Benchmarking mouse contamination removing protocols in patient-derived xenografts genomic profiling (Zheng, Wang, Kurmasheva, Houghton, Lai, & Chen Labs)
April 17, 2025Mukund Bhandari, Funan He, Anna Rogojina, Fuyang Li, Yi Zou, Jing Jiang, Zhao Lai, Peter Houghton, Raushan T. Kurmasheva, Yidong Chen, Xiaojing Wang & Siyuan Zheng Abstract Patient-derived xenograft (PDX) models are widely used in cancer research. …
Neuro-Oncology: Dual Inhibition of MAPK and TORC1 Signaling Retards Development of Radiation Resistance in Pediatric BRAF V600E Glioma Models (Chen, Houghton, et al labs)
April 11, 2025Abstract Background MAPK pathway inhibitors (MAPKi) have shown significant efficacy in treating childhood BRAF-activated brain tumors. For tumors harboring BRAFV600E mutations, the drugs are rarely curative, and patients can become refractory to treatm …
Molecular Cancer Therapeutics: Abstract B016: RNA demethylase ALKBH5 drives medulloblastoma growth and progression (Rao, Chen, Gupta, & Houghton Labs)
November 18, 2024Panneerdoss Subbarayalu; Daisy Medina; Pitta Prabhakar; Shahad Abdulsahib; Saif Nirzhor; Desiree Denman; Santosh Timilsina; Deepika Singh; Phat Do; Krishna Evani; Dhiya Billa; Esha Reddy; Peter Houghton; Yogesh Gupta; Yidong Chen; Suryavathi Viswanadha …
Pharmacology & Therapeutics: Lessons learned from 20 years of preclinical testing in pediatric cancers (Houghton, Kurmasheva)
November 11, 2024Malcolm A. Smith a, Peter J. Houghton b, Richard B. Lock c, John M. Maris d, Richard Gorlick e, Raushan T. Kurmasheva b, Xiao-Nan Li f, Beverly A. Teicher a, Jeffrey H. Chuang g, Filemon S. Dela Cruz h, Michael A. Dyer i, Andrew L. Kung h, Michael W. L …
MDPI Cancers: Synergistic Antitumor Activity of Talazoparib and Temozolomide in Malignant Rhabdoid Tumors (Kurmasheva, Lai, & Chen)
June 18, 2024Elena Mironova, Sebastian Molinas, Vanessa Del Pozo, Abhik M. Bandyopadhyay, Zhao Lai, Dias Kurmashev, Eric L. Schneider, Daniel V. Santi, Yidong Chen, Raushan T. Kurmasheva Simple Summary Mutation of the SMARCB1 gene can cause one …
IScience: Comprehensive Characterization of Patient-Derived Xenograft Models of Pediatric Leukemia (Houghton, Grimes, Lai, Chen, Zheng, Kurmasheva, & Tomlinson Labs)
December 6, 2023Anna Rogojina 1 12, Laura, J. Klesse 2 3 4 12, Erin Butler 2 3 4 12, Jiwoong Kim 5, He Zhang 5, Xue Xiao 5, Lei Guo 5, Qinbo Zhou 5, Taylor Hartshorne 2, Dawn Garcia 1, Korri Weldon 1, Trevor Holland 1, Abhik Bandyopadhyay 1, Luz Perez Prado 1, Shidan …
Nature Communications: Genomic profiling of subcutaneous patient-derived xenografts reveals immune constraints on tumor evolution in childhood solid cancer (Zheng, Grimes, Lai, Chen, Wang, Tomlinson, Houghton, & Kurmasheva Labs)
November 27, 2023Funan He, Abhik M. Bandyopadhyay, Laura J. Klesse, Anna Rogojina, Sang H. Chun, Erin Butler, Taylor Hartshorne, Trevor Holland, Dawn Garcia, Korri Weldon, Luz-Nereida Perez Prado, Anne-Marie Langevin, Allison C. Grimes, Aaron Sugalski, Shafqat Shah, Ch …
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