Zhao Lai, PhD to Receive $365K NIH Grant to Expand Integrated High-Performance Imaging-Based in-situ Spatial Profiling
July 8, 2025The 10x Genomics Xenium Analyzer is a cutting-edge, fully integrated platform for high-performance, imaging-based in situ spatial transcriptomics. It enables researchers to perform highly sensitive, high-throughput targeted gene expression profiling at …
NPJ – Precision Oncology: Benchmarking mouse contamination removing protocols in patient-derived xenografts genomic profiling (Zheng, Wang, Kurmasheva, Houghton, Lai, & Chen Labs)
April 17, 2025Mukund Bhandari, Funan He, Anna Rogojina, Fuyang Li, Yi Zou, Jing Jiang, Zhao Lai, Peter Houghton, Raushan T. Kurmasheva, Yidong Chen, Xiaojing Wang & Siyuan Zheng Abstract Patient-derived xenograft (PDX) models are widely used in cancer research. …
Pigment Cell & Melanoma: Segregation Between an Ornamental and a Disease Driver Gene Provides Insights Into Pigment Cell Regulation (Lai Lab)
September 25, 2024Erika Soria, Qiusheng Lu, Will Boswell, Kang Du, Yanting Xing, Mikki Boswell, Korri S. Weldon, Zhao Lai, Markita Savage, Manfred Schartl, Yuan Lu ABSTRACT Genetic interactions are adaptive within a species. Hybridization can disrupt such species-specif …
Journal of the National Cancer Institute: Integrative multi-omics characterization of hepatocellular carcinoma in Hispanic patients (Zheng, Chen & Lai Labs)
September 4, 2024Debodipta Das, PhD, Xiaojing Wang, PhD, Yu-Chiao Chiu, PhD, Hakim Bouamar, PhD, Francis E Sharkey, MD, Jorge E Lopera, MD, Zhao Lai, PhD, Susan T Weintraub, PhD, Xianlin Han, PhD, Yi Zou, MS, Hung-I H Chen, PhD, Carla R Zeballos Torrez, MD, PhD, Xiang …
MDPI Cancers: Synergistic Antitumor Activity of Talazoparib and Temozolomide in Malignant Rhabdoid Tumors (Kurmasheva, Lai, & Chen)
June 18, 2024Elena Mironova, Sebastian Molinas, Vanessa Del Pozo, Abhik M. Bandyopadhyay, Zhao Lai, Dias Kurmashev, Eric L. Schneider, Daniel V. Santi, Yidong Chen, Raushan T. Kurmasheva Simple Summary Mutation of the SMARCB1 gene can cause one …
Precision Oncology: Pharmacological inhibition of the LIF/LIFR autocrine loop reveals vulnerability of ovarian cancer cells to ferroptosis (Chen, Lai, Rao, et al)
June 17, 2024Behnam Ebrahimi, Suryavathi Viswanadhapalli, Uday P. Pratap, Gopalam Rahul, Xue Yang, Prabhakar Pitta Venkata, Viktor Drel, Bindu Santhamma, Swapna Konda, Xiaonan Li, Alondra Lee Rodriguez Sanchez, Hui Yan, Gangadhara R. Sareddy, Z …
Scientific Reports: Associations of tissue damage induced inflammatory plasticity in masseter muscle with the resolution of chronic myalgia (Lai)
January 4, 2024Abstract Gene plasticity during myogenous temporomandibular disorder (TMDM) development is largely unknown. TMDM could be modeled by intramuscular inflammation or tissue damage. To model inflammation induced TMDM we injected complete Freund’s adjuvant …
IScience: Comprehensive Characterization of Patient-Derived Xenograft Models of Pediatric Leukemia (Houghton, Grimes, Lai, Chen, Zheng, Kurmasheva, & Tomlinson Labs)
December 6, 2023Anna Rogojina 1 12, Laura, J. Klesse 2 3 4 12, Erin Butler 2 3 4 12, Jiwoong Kim 5, He Zhang 5, Xue Xiao 5, Lei Guo 5, Qinbo Zhou 5, Taylor Hartshorne 2, Dawn Garcia 1, Korri Weldon 1, Trevor Holland 1, Abhik Bandyopadhyay 1, Luz Perez Prado 1, Shidan …
Cold Spring Harbor, Spatial-Live: A lightweight and versatile tool for single cell spatial-omics data visualization (Chen, Zheng, Lai)
December 5, 2023Zhenqing Ye, Zhao Lai, Siyuan Zheng, Yidong Chen Abstract Single-cell spatial-omics data visualization plays a pivotal role in unraveling the intricate spatial organization and heterogeneity of cellular systems. Although various software tools and pack …
Nature Communications: Genomic profiling of subcutaneous patient-derived xenografts reveals immune constraints on tumor evolution in childhood solid cancer (Zheng, Grimes, Lai, Chen, Wang, Tomlinson, Houghton, & Kurmasheva Labs)
November 27, 2023Funan He, Abhik M. Bandyopadhyay, Laura J. Klesse, Anna Rogojina, Sang H. Chun, Erin Butler, Taylor Hartshorne, Trevor Holland, Dawn Garcia, Korri Weldon, Luz-Nereida Perez Prado, Anne-Marie Langevin, Allison C. Grimes, Aaron Sugalski, Shafqat Shah, Ch …
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