Greehey CCRI News & Events Archive

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PLoS One: microRNA-2110 functions as an onco-suppressor in neuroblastoma by directly targeting Tsukushi

December 14, 2018

Zhenze Zhao, Veronica Partridge, Michaela Sousares, Spencer D. Shelton, Cory L. Holland, Alexander Pertsemlidis, Liqin Du  Abstract microRNA-2110 (miR-2110) was previously identified as inducing neurite outgrowth in neuroblastoma cell lines BE(2)-C, su …


CRISPR – Journal: CRISPR-Based Editing Reveals Edge-Specific Effects in Biological Networks

August 1, 2018

Yi Li, Chance M. Nowak, Daniel Withers, Alexander Pertsemlidis, Leonidas Bleris Abstract Unraveling the properties of biological networks is central to understanding both normal and disease cellular phenotypes. Networks consist of functional elements ( …


Cancer Letters: miR-195 potentiates the efficacy of microtubule-targeting agents in non-small cell lung cancer

July 28, 2018

Xiaojie Yuab, Yiqiang Zhanga, Xiuye Maa, Alexander Pertsemlidisabc Abstract Microtubule-targeting agents (MTAs) are widely used for the treatment of non-small cell lung cancer (NSCLC). The response rate is only ∼25%, mainly attributable to drug resista …


Oncotarget: LMO1 functions as an oncogene by regulating TTK expression and correlates with neuroendocrine differentiation of lung cancer

July 3, 2018

Liqin Du1, Zhenze Zhao1, Milind Suraokar2, Spencer S. Shelton1, Xiuye Ma3, Tzu-Hung Hsiao4, John D. Minna5, Ignacio Wistuba2,6 and Alexander Pertsemlidis3,7 ABSTRACT LMO1 encodes a protein containing a cysteine-rich LIM domain involved in protein-prote …


Cell Death & Disease: miR-195 targets cyclin D3 and survivin to modulate the tumorigenesis of non-small cell lung cancer

February 7, 2018

Xiaojie Yu, Yiqiang Zhang, David Cavazos, Xiuye Ma, Zhenze Zhao, Liqin Du & Alexander Pertsemlidis Abstract miR-195 has recently been reported to function as a tumor suppressor in various cancers, including non-small cell lung cancer (NSCLC). Howev …


Scientific Reports: A miR-SNP biomarker linked to an increased lung cancer survival by miRNA-mediated down-regulation of FZD4 expression and Wnt signaling

August 22, 2017

Jing Lin, Roza Zandi, Ruping Shao, Jian Gu, Yuanqin Ye, Jing Wang, Yang Zhao, Alexander Pertsemlidis, Ignacio I. Wistuba, Xifeng Wu, Jack A. Roth & Lin Ji Abstract Through a new hypothesis-driven and microRNA-pathway-based SNP (miR-SNP) association …


Oncotarget: A combined gene expression and functional study reveals the crosstalk between N-Myc and differentiation-inducing microRNAs in neuroblastoma cells

October 15, 2016

Zhenze Zhao1, Xiuye Ma2, Spencer D. Shelton1, Derek C. Sung3, Monica Li4, Daniel Hernandez5, Maggie Zhang6, Michael D. Losiewicz7, Yidong Chen8, Alexander Pertsemlidis2,9,10, Xiaojie Yu11, Yuanhang Liu11, Liqin Du1 ABSTRACT MYCN amplification is the mo …


European Journal of Medicinal Chemistry: 5,10b-Ethanophenanthridine amaryllidaceae alkaloids inspire the discovery of novel bicyclic ring systems with activity against drug resistant cancer cells

September 14, 2016

Author links open overlay panelAuthor links open overlay panelSean Henrya\, Ria Kidnera, Mary R.Reisenauera, Igor V .Magedova, Robert Kissb, Véronique Mathieub, Florence Lefrancc, Ramesh Dasarid, Antonio Evidentee, Xiaojie Yuf, Xiuye Maf, Alexander Per …


San Antonio Report: Commentary: Are Questions More Powerful Than Answers?

July 23, 2016

In the afternoon, the students had an opportunity to meet with Dr. Alexander Pertsemlidis, associate professor of pediatrics, hematology, and oncology at the Greehey Children’s Cancer Research Institute at the University of Texas Health Science Center. …


San Antonio Business Journal: SA biotech company and Health Science Center to use the power of collaboration to combat cancer

July 13, 2016

One of San Antonio’s more promising bioscience companies, bioAffinity Technologies Inc., has locked up a key deal, renewing its collaborative agreement with the University of Texas Health Science Center at San Antonio. The extension will allow the two …