Greehey CCRI News & Events Archive

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Experimental Biology and Medicine: Original Research: A case-control genome-wide association study identifies genetic modifiers of fetal hemoglobin in sickle cell disease

March 27, 2016

Li Liu, Alexander Pertsemlidis, Liang-Hao Ding, Michael D Story, Martin H Steinberg, Paola Sebastiani, Carolyn Hoppe, Samir K Ballas, Betty S Pace Abstract Sickle cell disease (SCD) is a group of inherited blood disorders that have in common a mutation …


RNA Biology: microRNA-449a functions as a tumor suppressor in neuroblastoma through inducing cell differentiation and cell cycle arrest

May 6, 2015

Zhenze ZhaoGreehey Children’s Cancer Research Institute; ,Xiuye Ma,Derek Sung,Monica Li,Adam Kosti,Gregory Lin,Yidong Chen,Alexander Pertsemlidis,Tzu-Hung Hsiao &Liqin Du Abstract microRNA-449a (miR-449a) has been identified to function as a tumor …


Fitoterapia: Jonquailine, a new pretazettine-type alkaloid isolated from Narcissus jonquilla quail, with activity against drug-resistant cancer

April 1, 2015

Marco Masi 1, Liliya V Frolova 2, Xiaojie Yu 3, Véronique Mathieu 4, Alessio Cimmino 1, Annelise De Carvalho 4, Robert Kiss 4, Snezna Rogelj 2, Alexander Pertsemlidis 3, Alexander Kornienko 5, Antonio Evidente 6 Abstract A new alkaloid, belonging to th …


PLoS One: Genome-Wide Association Analysis of Radiation Resistance in Drosophila melanogaster

August 14, 2014

Mahesh Vaisnav, Chao Xing, Hung-Chih Ku, Daniel Hwang, Strahinja Stojadinovic, Alexander Pertsemlidis, John M. Abrams  Abstract Background Ionizing radiation is genotoxic to cells. Healthy tissue toxicity in patients and radiation resistance in tumors …


Science Daily: Improved screening means new targets for pediatric neuroblastoma therapies

March 2, 2014

Neuroblastoma is one of the most common and lethal types of childhood cancers. In a paper recently published, a researcher unveils an improved screening technique that shows the important role of microRNAs in regulating neuroblastoma development, point …


Oncotarget: A high-content morphological screen identifies novel microRNAs that regulate neuroblastoma cell differentiation

February 28, 2014

Zhenze Zhao1, Xiuye Ma1, Tzu-Hung Hsiao1, Gregory Lin1, Adam Kosti1, Xiaojie Yu2, Uthra Suresh1, Yidong Chen1,3, Gail E. Tomlinson1,4, Alexander Pertsemlidis1,4,5, Liqin Du1,5 ABSTRACT Neuroblastoma, the most common extracranial solid tumor of childhoo …


Taylor Francis: A high-throughput screen identifies miRNA inhibitors regulating lung cancer cell survival and response to paclitaxel

September 30, 2013

Liqin Du, Robert Borkowski, Zhenze Zhao, Xiuye Ma, Xiaojie Yu, Xian-Jin Xie &Alexander Pertsemlidis microRNAs (miRNAs) are small RNAs endogenously expressed in multiple organisms that regulate gene expression largely by decreasing levels of target …


Oncogene:miR-93-directed downregulation of DAB2 defines a novel oncogenic pathway in lung cancer

September 16, 2013

L Du, Z Zhao, X Ma, T-H Hsiao, Y Chen, E Young, M Suraokar, I Wistuba, J D Minna & A Pertsemlidis Abstract The disabled homolog 2 (DAB2) gene was recently identified as a tumor suppressor gene with its expression downregulated in multiple cancer ty …


PLOS One: Genomic Loss of Tumor Suppressor miRNA-204 Promotes Cancer Cell Migration and Invasion by Activating AKT/mTOR/Rac1 Signaling and Actin Reorganization

December 21, 2012

J. Saadi Imam, Jason R. Plyler , Hima Bansal , Suresh Prajapati , Sanjay Bansal, Jennifer Rebeles, Hung-I Harry Chen, Yao-Fu Chang, Subbarayalu Panneerdoss, Behyar Zoghi, Kalyan C. Buddavarapu, Russell Broaddus, Peter Hornsby, Gail Tomlinson, Jeffrey D …


Journal of Clinical Investigation: ZEB1 drives prometastatic actin cytoskeletal remodeling by downregulating miR-34a expression

August 1, 2012

Young-Ho Ahn,1 Don L. Gibbons,1,2 Deepavali Chakravarti,3 Chad J. Creighton,4 Zain H. Rizvi,1 Henry P. Adams,5 Alexander Pertsemlidis,6 Philip A. Gregory,7,8 Josephine A. Wright,7,8 Gregory J. Goodall,7,8,9 Elsa R. Flores,3 and Jonathan M. Kurie1 Abstr …