Greehey CCRI Archives
Cancer Research: M6A RNA Methylation Regulates Histone Ubiquitination to Support Cancer Growth and Progression (Gupta, Zheng, Houghton, Chen, and Rao Labs)
March 21, 2022Pooja Yadav; Panneerdoss Subbarayalu; Daisy Medina, Saif Nirzhor; Santosh Timilsina; Subapriya Rajamanickam; Vijay K. Eedunuri; Yogesh Gupta Siyuan Zheng Nourhan Abdelfattah Yufei Huang Ratna Vadlamudi Robert Hromas; Paul Meltzer Peter Houghton; Yidon …
eLife: Signature-scoring methods developed for bulk samples are not adequate for cancer single-cell RNA sequencing data (Zheng, Chen, & Wang Labs)
March 7, 2022Nighat Noureen, Zhenqing Ye, Yidong Chen, Xiaojing Wang, Siyuan Zheng Abstract Quantifying the activity of gene expression signatures is common in analyses of single-cell RNA sequencing data. Methods originally developed for bulk samples are often …
MSN: Using Next Generation Sequencing, the Greehey CCRI bioinformatics team is helping determine COVID19 strains (Chen, Lai, Zheng, Wang Labs)
December 17, 2021“Since the coronavirus pandemic began almost two years ago there have been over a dozen strains of the virus. Here at UT Health San Antonio, they have a lab which differentiates between each of the strains in an effort to save lives. UT Health San Anto …
CANCER RESEARCH: SNAI2-Mediated Repression of BIM Protects Rhabdomyosarcoma from Ionizing Radiation (Houghton, Ignatius, Vaseva, and Zheng labs)
November 24, 2021Long Wang, Nicole R. Hensch, Kathryn Bondra, Prethish Sreenivas, Xiang R. Zhao, Jiangfei Chen, Rodrigo Moreno Campos, Kunal Baxi, Angelina V. Vaseva, Benjamin D. Sunkel, Berkley E. Gryder, Silvia Pomella, Benjamin Z. Stanton, Siyuan Zheng, Eleanor Y. C …
Cancer Research: SNAI2-mediated repression of BIM protects rhabdomyosarcoma from ionizing radiation (Houghton, Ignatius, & Zheng Labs)
August 31, 2021Long Wang, Nicole R. Hensch, Kathryn Bondra, Prethish Sreenivas, Xiang R. Zhao, Jiangfei Chen, Rodrigo Moreno Campos, Kunal Baxi, Angelina V. Vaseva, Benjamin D. Sunkel, Berkley E. Gryder, Silvia Pomella, Benjamin Z. Stanton, Siyuan Zheng, Eleanor Y. C …
Science Advances: Predicting and characterizing a cancer dependency map of tumors with deep learning (Aune, Chen, Rao, Houghton & Zheng Labs)
August 24, 2021Yu-Chiao Chiu1, Siyuan Zheng1,2, Li-Ju Wang1, View ORCID ProfileBrian S. Iskra1, View ORCID ProfileManjeet K. Rao1,3, Peter J. Houghton1,4, View ORCID ProfileYufei Huang5,6,* and View ORCID ProfileYidong Chen1,2,* Abstract Genome-wide loss-of-function …
Science Advances: Regulation of telomere homeostasis and genomic stability in cancer by N6-adenosine methylation (m6A) (Rao & Zheng Labs)
July 29, 2021View ORCID ProfileJi Hoon Lee1,†, View ORCID ProfileJuyeong Hong1,†, View ORCID ProfileZhao Zhang1,†, View ORCID ProfileBárbara de la Peña Avalos2,3, View ORCID ProfileCecilia J. Proietti4, View ORCID ProfileAgustina Roldán Deamicis4, View ORCID Profil …
Nighat Noureen, PhD, Awarded CPRIT Postdoctoral Training Award (Zheng Lab)
March 10, 2021Congratulations to Nighat Noureen, PhD, a postdoctoral fellow in the lab of Greehey CCRI principal investigator, Siyuan Zheng, PhD, on recently being awarded a CPRIT fellowship training grant. Dr. Noureen joined Dr. Zheng’s lab in June 20 …
Cell Press: A Modular Master Regulator Landscape Controls Cancer Transcriptional Identity (Zheng Lab)
January 21, 2021Evan O.Paull114, Alvaro Aytes121314, Sunny J.Jones114, Prem S.Subramaniam1, Federico M.Giorgi3, Eugene F.Douglass1, Somnath Tagore1, Brennan Chu1, Alessandro Vasciaveo1, Siyuan Zheng4, Roel Verhaak5, Cory Abate-Shen1678, Mariano J.Alvarez19 …
Nature Communications: Integrated analysis of telomerase enzymatic activity unravels an association with cancer stemness and proliferation (Zheng Lab)
January 12, 2021Nighat Noureen, Shaofang Wu, Yingli Lv, Juechen Yang, W. K. Alfred Yung, Jonathan Gelfond, Xiaojing Wang, Dimpy Koul, Andrew Ludlow & Siyuan Zheng Abstract Active telomerase is essential for stem cells and most cancers t …