Greehey CCRI Archives
Alexander J.R. Bishop, DPhil. & Aparna Gorthi, PhD, Co-Author Nature Research Paper
July 15, 2020Bishop Gorthi “Nucleolar RNA Polymerase II Drives Ribosome Biogenesis” Publication Date: July 15, 2020 Abstract Proteins are manufactured by ribosomes—macromolecular complexes of protein and RNA molecules that are assembled within …
Nature: Nucleolar RNA polymerase II drives ribosome biogenesis
July 15, 2020Karan J. Abraham, Negin Khosraviani, Janet N. Y. Chan, Aparna Gorthi, Anas Samman, Dorothy Y. Zhao, Miling Wang, Michael Bokros, Elva Vidya, Lauren A. Ostrowski, Roxanne Oshidari, Violena Pietrobon, Parasvi S. Patel, Arash Algouneh, Rajat Singhania, Yu …
Graduate Student Awarded CPRIT 2020 Predoctoral Training Fellowship (Bishop Lab)
June 22, 2020Congratulations to Pramiti Mukhopadhyay, Graduate Research Assistant in Alexander J. R. Bishop DPhil lab, on recently being awarded a CPRIT 2020 Predoctoral Training Fellowship. This valuable funding will help Ms. Mukhopadhyay continue her Ewing sarco …
Nucleic Acids Research: Cohesin SA1 and SA2 are RNA binding proteins that localize to RNA containing regions on DNA (Bishop)
April 30, 2020Hai Pan, Miao Jin, Ashwin Ghadiyaram, Parminder Kaur, Henry E Miller, Hai Minh Ta, Ming Liu, Yanlin Fan, Chelsea Mahn, Aparna Gorthi … Show more Abstract Cohesin SA1 (STAG1) and SA2 (STAG2) are key components of the cohesin complex. Previous studie …
MDPI Cancers Magazine – Reconstruction of Ewing Sarcoma Developmental Context from Mass-Scale Transcriptomics Reveals Characteristics of EWSR1-FLI1 Permissibility (Bishop Lab)
April 16, 2020by Henry E. Miller 1,2, Aparna Gorthi 1,2, Nicklas Bassani 2, Liesl A. Lawrence 1,2, Brian S. Iskra 1,2 and Alexander J. R. Bishop 1,2,* This study aims at defining the features of the cell of origin for Ewing sarcoma through comparative bioinformatic …
bioRxiv : Assessing the Heterogeneity of Cardiac Non-myocytes and the Effect of Cell Culture with Integrative Single Cell Analysis
March 4, 2020Abstract Cardiac non-myocytes comprise a diverse and crucial cell population in the heart that plays dynamic roles in cardiac wound healing and growth. Non-myocytes broadly fall into four cell types: endothelium, fibroblasts, leukocytes, and pericytes. …
Pipette Gazette: Kevin Kanda, From Nursing Student To Graduate Student (Bishop Lab)
February 20, 2020Kevin Kanda made a promise to his family to try to fight cancer. “I’ve lost some family and friends to cancer….my uncle died from lymphoma and I’ve known people with pancreatic and breast cancer as well,” he said. Initially, Kanda thought nursing would …
NATURE: Bishop lab helps discovery of R-loops in the pediatric cancer Embryonal tumors with multilayered rosettes (ETMRs)
December 18, 2019Briefings in Bioinformatics: Deep learning of pharmacogenomics resources: moving towards precision oncology
December 8, 2019Yu-Chiao Chiu, Hung-I Harry Chen, Aparna Gorthi, Milad Mostavi, Siyuan Zheng, Yufei Huang, Yidong Chen Abstract The recent accumulation of cancer genomic data provides an opportunity to understand how a tumor’s genomic characteristics can affect its re …
Pediatric Blood & Cancer: Phase 1/2 trial of talazoparib in combination with temozolomide in children and adolescents with refractory/recurrent solid tumors including Ewing sarcoma: A Children’s Oncology Group Phase 1 Consortium study (ADVL1411)
November 14, 2019Abstract Purpose We conducted a phase 1/2 trial of the poly(ADP‐ribose) polymerase 1/2 inhibitor talazoparib in combination with low‐dose temozolomide (TMZ) to determine the dose‐limiting toxicities (DLTs), recommended phase 2 dose (RP2D), and pharmaco …