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Graduate Student Awarded CPRIT 2020 Predoctoral Training Fellowship (Bishop Lab)

June 22, 2020

Congratulations to Pramiti Mukhopadhyay, Graduate Research Assistant in Alexander J. R. Bishop DPhil lab, on recently being awarded a CPRIT 2020 Predoctoral Training Fellowship.  This valuable funding will help Ms. Mukhopadhyay continue her Ewing sarco …

Nucleic Acids Research: Cohesin SA1 and SA2 are RNA binding proteins that localize to RNA containing regions on DNA (Bishop)

April 30, 2020

Hai Pan, Miao Jin, Ashwin Ghadiyaram, Parminder Kaur, Henry E Miller, Hai Minh Ta, Ming Liu, Yanlin Fan, Chelsea Mahn, Aparna Gorthi … Show more   Abstract Cohesin SA1 (STAG1) and SA2 (STAG2) are key components of the cohesin complex. Previous studie …

MDPI Cancers Magazine – Reconstruction of Ewing Sarcoma Developmental Context from Mass-Scale Transcriptomics Reveals Characteristics of EWSR1-FLI1 Permissibility (Bishop Lab)

April 16, 2020

by  Henry E. Miller 1,2, Aparna Gorthi 1,2, Nicklas Bassani 2, Liesl A. Lawrence 1,2, Brian S. Iskra 1,2 and Alexander J. R. Bishop 1,2,* This study aims at defining the features of the cell of origin for Ewing sarcoma through comparative bioinformatic …

bioRxiv : Assessing the Heterogeneity of Cardiac Non-myocytes and the Effect of Cell Culture with Integrative Single Cell Analysis

March 4, 2020

Abstract Cardiac non-myocytes comprise a diverse and crucial cell population in the heart that plays dynamic roles in cardiac wound healing and growth. Non-myocytes broadly fall into four cell types: endothelium, fibroblasts, leukocytes, and pericytes. …

Pipette Gazette: Kevin Kanda, From Nursing Student To Graduate Student (Bishop Lab)

February 20, 2020

Kevin Kanda made a promise to his family to try to fight cancer. “I’ve lost some family and friends to cancer….my uncle died from lymphoma and I’ve known people with pancreatic and breast cancer as well,” he said. Initially, Kanda thought nursing would …

NATURE: Bishop lab helps discovery of R-loops in the pediatric cancer Embryonal tumors with multilayered rosettes (ETMRs)

December 18, 2019

Briefings in Bioinformatics: Deep learning of pharmacogenomics resources: moving towards precision oncology

December 8, 2019

Yu-Chiao Chiu, Hung-I Harry Chen, Aparna Gorthi, Milad Mostavi, Siyuan Zheng, Yufei Huang, Yidong Chen Abstract The recent accumulation of cancer genomic data provides an opportunity to understand how a tumor’s genomic characteristics can affect its re …

Pediatric Blood & Cancer: Phase 1/2 trial of talazoparib in combination with temozolomide in children and adolescents with refractory/recurrent solid tumors including Ewing sarcoma: A Children’s Oncology Group Phase 1 Consortium study (ADVL1411)

November 14, 2019

Abstract Purpose We conducted a phase 1/2 trial of the poly(ADP‐ribose) polymerase 1/2 inhibitor talazoparib in combination with low‐dose temozolomide (TMZ) to determine the dose‐limiting toxicities (DLTs), recommended phase 2 dose (RP2D), and pharmaco …

YouTube: Experimental Biology TV, WebsEdgeMedicine

April 4, 2019 “Cancers in children are rare, and the genetics and epigenetic causes are very different from those of adults. Consequently, the study of the etiology and potential therapies for these tumors requir …

BMC Medical Genomics: Predicting drug response of tumors from integrated genomic profiles by deep neural networks

January 31, 2019

Yu-Chiao Chiu, Hung-I Harry Chen, Tinghe Zhang, Songyao Zhang, Aparna Gorthi, Li-Ju Wang, Yufei Huang & Yidong Chen Abstract Background The study of high-throughput genomic profiles from a pharmacogenomics viewpoint has provided unprecedented insig …