Greehey CCRI News & Events Archive

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UT Health SA Newsroom: Do all chemotherapies have equal heart risk long term?

January 31, 2019

Study of 28,000 childhood cancer survivors finds important differences In long-term survivors of childhood cancer, cardiovascular disease is a leading cause of early death from non-cancer causes. In a new study, published Jan. 31 in JAMA Oncology, rese …


BMC Medical Genomics: Predicting drug response of tumors from integrated genomic profiles by deep neural networks

January 31, 2019

Yu-Chiao Chiu, Hung-I Harry Chen, Tinghe Zhang, Songyao Zhang, Aparna Gorthi, Li-Ju Wang, Yufei Huang & Yidong Chen Abstract Background The study of high-throughput genomic profiles from a pharmacogenomics viewpoint has provided unprecedented insig …


JAMA Oncology: Derivation of Anthracycline and Anthraquinone Equivalence Ratios to Doxorubicin for Late-Onset Cardiotoxicity

January 31, 2019

Elizabeth A. M. Feijen, PhD1,2; Wendy M. Leisenring, ScD3,4; Kayla L. Stratton, MS3,4; Kirsten K. Ness, PT, PhD5; Helena J. H. van der Pal, MD, PhD2; Elvira C. van Dalen, MD, PhD1,2; Gregory T. Armstrong, MD, MSCE5; Gregory J. Aune, MD, PhD6; Daniel M. …


EurekAlert: Do all chemotherapies have equal long-term heart risk?

January 21, 2019

SAN ANTONIO — In long-term survivors of childhood cancer, cardiovascular disease is a leading cause of early death from non-cancer causes. In a new study, published Jan. 31 in JAMA Oncology, researchers compared four chemotherapy drugs with the develo …


MDPI: CENP-A Ubiquitylation Contributes to Maintaining the Chromosomal Location of the Centromere

January 15, 2019

Yohei Niikura 1,2,* Risa Kitagawa 1 and Katsumi Kitagawa 1,* Abstract The centromere plays an essential role in accurate chromosome segregation, and the chromosomal location of the centromere is determined by the presence of a histone H3 variant, centr …


PLOS Computational Biology: Global analysis of N6-methyladenosine functions and its disease association using deep learning and network-based methods

January 2, 2019

Song-Yao Zhang, Shao-Wu Zhang, Xiao-Nan Fan, Jia Meng, Yidong Chen, Shou-Jiang Gao, Yufei Huang Abstract N6-methyladenosine (m6A) is the most abundant methylation, existing in >25% of human mRNAs. Exciting recent discoveries indicate the close invol …


BMC Systems Biology: GSAE: an autoencoder with embedded gene-set nodes for genomics functional characterization

December 21, 2018

Hung-I Harry Chen, Yu-Chiao Chiu, Tinghe Zhang, Songyao Zhang, Yufei Huang & Yidong Chen Abstract Background Bioinformatics tools have been developed to interpret gene expression data at the gene set level, and these gene set-based analyses improve …


BMC Systems Biology: scdNet: a computational tool for single-cell differential network analysis

December 21, 2018

Yu-Chiao Chiu, Tzu-Hung Hsiao, Li-Ju Wang, Yidong Chen & Yu-Hsuan Joni Shao Abstract Background Single-cell RNA sequencing (scRNA-Seq) is an emerging technology that has revolutionized the research of tumor heterogeneity. However, the highly sparse …


PLoS One: microRNA-2110 functions as an onco-suppressor in neuroblastoma by directly targeting Tsukushi

December 14, 2018

Zhenze Zhao, Veronica Partridge, Michaela Sousares, Spencer D. Shelton, Cory L. Holland, Alexander Pertsemlidis, Liqin Du  Abstract microRNA-2110 (miR-2110) was previously identified as inducing neurite outgrowth in neuroblastoma cell lines BE(2)-C, su …


Tiny molecule has big effect in childhood brain tumor studies

December 6, 2018

Sometimes small things make the biggest difference. A new study by UT Health San Antonio researchers found that a molecule thousands of times smaller than a gene are able to kill medulloblastoma, the most common childhood brain cancer.


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