Greehey CCRI News & Events Archive

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JCI Insight: IL-6 and CXCL8 mediate osteosarcoma-lung interactions critical to metastasis

August 23, 2018

Amy C. Gross,1 Hakan Cam,1,2 Doris A. Phelps,3 Amanda J. Saraf,2,4 Hemant K. Bid,1,2 Maren Cam,1 Cheryl A. London,5,6 Sarah A. Winget,1 Michael A. Arnold,7,8 Laura Brandolini,9 Xiaokui Mo,10 John M. Hinckley,1,11 Peter J. Houghton,3 and Ryan D. Roberts …


UT Health SA Newsroom: CPRIT awards millions to UT Health San Antonio

August 18, 2018

Cancer prevention programs and initiatives to recruit faculty to UT Health San Antonio got a $3.5 million boost from the Cancer Prevention & Research Institute of Texas (CPRIT). The awards, announced Aug. 16, bringing total funding to UT Health San …


UT Health SA Newsroom: UT Health San Antonio physician-researcher contributes to international screening guidelines for rare pediatric cancers

August 2, 2018

SAN ANTONIO (Aug. 2, 2017) ―Approximately 10 percent of childhood cancer can be attributed to genetics. While genomic analysis has been used for some time to identify the risk of inherited cancer in adults, scientists are now using genomic analysis to …


CRISPR – Journal: CRISPR-Based Editing Reveals Edge-Specific Effects in Biological Networks

August 1, 2018

Yi Li, Chance M. Nowak, Daniel Withers, Alexander Pertsemlidis, Leonidas Bleris Abstract Unraveling the properties of biological networks is central to understanding both normal and disease cellular phenotypes. Networks consist of functional elements ( …


Cancer Letters: miR-195 potentiates the efficacy of microtubule-targeting agents in non-small cell lung cancer

July 28, 2018

Xiaojie Yuab, Yiqiang Zhanga, Xiuye Maa, Alexander Pertsemlidisabc Abstract Microtubule-targeting agents (MTAs) are widely used for the treatment of non-small cell lung cancer (NSCLC). The response rate is only ∼25%, mainly attributable to drug resista …


Oncotarget: Increased expression of the thyroid hormone nuclear receptor TRα1 characterizes intestinal tumors with high Wnt activity

July 24, 2018

Joel Uchuya-Castillo, Nicolas Aznar, Carla Frau, Pierre Martinez, Clementine Le Nevé, Laetitia Marisa, Luiz OF Penalva, Pierre Laurent-Puig, Alain Puisieux, Jean-Yves Scoazec, Jacques Samarut, Stephane Ansieau, Michelina Plateroti Our previous work dem …


Journal of Clinical Oncology: Cardiovascular Disease in Survivors of Childhood Cancer: Insights Into Epidemiology, Pathophysiology, and Prevention

July 20, 2018

Saro H. Armenian, Gregory T. Armstrong, Gregory Aune, Eric J. Chow, Matthew J. Ehrhardt, Bonnie Ky,  ABSTRACT Cardiovascular disease (CVD), which includes cardiomyopathy/heart failure, coronary artery disease, stroke, pericardial disease, arrhythmias, …


Cell Report: Opposing Tumor-Promoting and -Suppressive Functions of Rictor/mTORC2 Signaling in Adult Glioma and Pediatric SHH Medulloblastoma

July 10, 2018

Seçkin Akgül 1, Yinghua Li 2, Siyuan Zheng 3, Marcel Kool 4, Daniel M Treisman 5, Chaoyang Li 2, Yuan Wang 2, Susanne Gröbner 4, Tsuneo Ikenoue 6, Yiping Shen 7, Sandra Camelo-Piragua 8, Gerald Tomasek 9, Sebastian Stark 4, Vinay Guduguntla 9, James F …


Oncotarget: LMO1 functions as an oncogene by regulating TTK expression and correlates with neuroendocrine differentiation of lung cancer

July 3, 2018

Liqin Du1, Zhenze Zhao1, Milind Suraokar2, Spencer S. Shelton1, Xiuye Ma3, Tzu-Hung Hsiao4, John D. Minna5, Ignacio Wistuba2,6 and Alexander Pertsemlidis3,7 ABSTRACT LMO1 encodes a protein containing a cysteine-rich LIM domain involved in protein-prote …


Cancer Letters: Sorafenib improves alkylating therapy by blocking induced inflammation, invasion and angiogenesis in breast cancer cells

July 1, 2018

AlfeuZanotto-Filhoac  SubapriyaRajamanickama  EvaLoranca  V. Pragathi Masamsettia  AparnaGorthiab  July CarolinaRomeroab  SonalTonapiab  Rosangela Mayer Gonçalvesc  Robert L.Reddickd  RaymondBenavidese  JohnKuhnde  YidongChenf  Alexander J.R.Bishopab A …


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