Greehey CCRI News & Events Archive

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Scientific Reports: Patient-derived conditionally reprogrammed cells maintain intra-tumor genetic heterogeneity

March 6, 2018

Bruna RS Correa, Joanna Hu, Luiz OF Penalva, Richard Schlegel, David L Rimm, Pedro AF Galante, Seema Agarwal Preclinical in vitro models provide an essential tool to study cancer cell biology as well as aid in translational research, including drug tar …

Molecular & Cellular Proteomics: Detection of proteome diversity resulted from alternative splicing is limited by trypsin cleavage specificity

March 1, 2018

Xiaojing Wang, Simona G Codreanu, Bo Wen, Kai Li, Matthew C Chambers, Daniel C Liebler, Bing Zhang Alternative splicing dramatically increases transcriptome complexity but its contribution to proteome diversity remains controversial. Exon-exon junction …

Cell Stem Cell: Vangl2/RhoA Signaling Pathway Regulates Stem Cell Self-Renewal Programs and Growth in Rhabdomyosarcoma

March 1, 2018

Madeline N Hayes 1, Karin McCarthy 1, Alexander Jin 1, Mariana L Oliveira 2, Sowmya Iyer 1, Sara P Garcia 1, Sivasish Sindiri 3, Berkley Gryder 3, Zainab Motala 4, G Petur Nielsen 5, Jean-Paul Borg 6, Matt van de Rijn 7, David Malkin 4, Javed Khan 3, M …

European Urology: Germline DNA-repair Gene Mutations and Outcomes in Men with Metastatic Castration-resistant Prostate Cancer Receiving First-line Abiraterone and Enzalutamide

February 10, 2018

Emmanuel S.Antonarakisab†, ChangxueLub†  BrandonLubera  ChaoLiangb  HaoWanga  YanChenb  John L.Silbersteinb DaniloPianab ZhaoLaic YidongChencd William B.Isaacsab JunLuoab Abstract Background Inherited DNA-repair gene mutations are more prevalent in men …

Cell Death & Disease: miR-195 targets cyclin D3 and survivin to modulate the tumorigenesis of non-small cell lung cancer

February 7, 2018

Xiaojie Yu, Yiqiang Zhang, David Cavazos, Xiuye Ma, Zhenze Zhao, Liqin Du & Alexander Pertsemlidis Abstract miR-195 has recently been reported to function as a tumor suppressor in various cancers, including non-small cell lung cancer (NSCLC). Howev …

Bexar County Medical Society: Through cancer care and research, UT Health San Antonio serves South Texas’ most seriously ill children (Aune & Tomlinson Labs)

February 1, 2018

Through cancer care and research, UT Health San Antonio serves South Texas’ most seriously ill children.

Bexar County Medical Society

February 1, 2018

Childhood Obesity: Characterization of the Stool Microbiome in Hispanic Preschool Children by Weight Status and Time

February 1, 2018

Emily B Hollister 1 2, Byron A Foster 3, Mahmoud Dahdouli 1 2, Jesica Ramirez 4, Zhao Lai 5 Abstract Background: Variations in gut microbiota composition and diversity have been associated with childhood adiposity, although most studies describing this …

Research Features: Battling brain tumours – novel therapies to treat astrocytomas

January 31, 2018

The key mission of Greehey Children’s Cancer Research Institute is to advance scientific knowledge and develop novel therapies relevant to pediatric cancer. Their director, Dr. Peter Houghton, and his team work hard to further our understanding of sarc …

Atlas of Science: The position of the centromere is marked with ubiquitylation of CENP-A

January 30, 2018

Chromosomes must segregate equally between daughter cells during cell division, and for proper chromosome segregation, spindle microtubules must attach to a single region of each chromosome, termed the “centromere,” in most eukaryotes. The kinetochore …

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