Greehey CCRI News & Events Archive

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Human Genetics: From mechanisms to therapy: RNA processing’s impact on human genetics

September 1, 2017

Authors Luiz O Penalva, Jeremy R Sanford Protein-coding genes defy the one gene-one enzyme paradigm, in part, through the process of alternative pre-mRNA splicing. This mode of gene regulation is critical for generating protein isoforms with specific f …


Journal of Clinical and Translational Science: 2337: Doxorubicin exposure in vitro stimulates ROS production and directly suppresses cardiac fibroblast proliferation

September 1, 2017

Trevi A. Mancilla (a1) and Gregory J. Aune (a1) Abstract OBJECTIVES/SPECIFIC AIMS: Our research strives to understand the pathophysiology of doxorubicin cardiotoxicity, focusing on the understudied nonmyocyte cardiac cells. Our understanding will enabl …


Cell Cycle: SGT1-HSP90 complex is required for CENP-A deposition at centromeres

August 17, 2017

Yohei Niikura,Risa Kitagawa,Hiroo Ogi &Katsumi Kitagawa ABSTRACT The centromere plays an essential role in accurate chromosome segregation, and defects in its function lead to aneuploidy and thus cancer. The centromere-specific histone H3 variant C …


CPRIT Grant: Recruitment of First-Time, Tenure-Track Faculty Members

August 16, 2017

“Big Data” is a driving force in cancer research today. Sifting through the data from thousands of cancer genomes will help researchers understand what drives cancer, and help them make predictions about therapies that will be most beneficial to indivi …


Texas Public Radio: Zebrafish May Help Scientists Find New Cancer Treatments

August 10, 2017

The key to finding a better way to treat a deadly form of childhood cancer may lie in a tiny fish. An unlikely animal model at UT Health San Antonio is helping scientists figure out how to tackle muscle tumors. Inside a fish lab at the Greehey Children …


Texas Public Radio: Zebrafish May Help Scientists Find New Cancer Treatments

August 10, 2017

The key to finding a better way to treat a deadly form of childhood cancer may lie in a tiny fish. An unlikely animal model at UT Health San Antonio is helping scientists figure out how to tackle muscle tumors. Inside a fish lab at the Greehey Children …


Cancer Knowledge Network: Risk Factors for Decreased Bone Mineral Density in Survivors of Childhood Cancer

August 3, 2017

 Pediatric Blood and Cancer: Risk factors and surveillance for reduced bone mineral density in pediatric cancer survivors.  Between 2003 and 2010, 475 survivors of childhood leukemia and solid tumors (excluding central nervous system tumors) were scree …


Cancer Research: IGFBP7 Deletion Promotes Hepatocellular Carcinoma

August 1, 2017

Maaged Akiel, Chunqing Guo, Xia Li, Devaraja Rajasekaran, Rachel G. Mendoza, Chadia L. Robertson, Nidhi Jariwala, Fang Yuan, Mark A. Subler, Jolene Windle, Dawn K. Garcia, Zhao Lai, Hung-I Harry Chen, Yidong Chen, Shah Giashuddin, Paul B. Fisher, Xiang …


Cancer Knowledge Network: Aging Survivors and Endocrine Disorders

July 27, 2017

 Journal of Clinical Oncology:  Endocrine Abnormalities in Aging Survivors of Childhood Cancer:  A Report From the Childhood Cancer Survivor Study.  Researchers in the United States analyzed the frequency of a range of endocrine disorders reported by 1 …


PLOS One: Target specificity, “in vivo” pharmacokinetics, and efficacy of the putative STAT3 inhibitor LY5 in osteosarcoma, Ewing’s sarcoma, and rhabdomyosarcoma

July 27, 2017

Peter Y. Yu , Heather L. Gardner , Ryan Roberts, Hakan Cam, Seethalakshmi Hariharan, Ling Ren, Amy K. LeBlanc, Hui Xiao, Jiayuh Lin, Denis C. Guttridge, Xiaokui Mo, Chad E. Bennett, Christopher C. Coss, Yonghua Ling, Mitch A. Phelps, Peter Houghton, Ch …