Greehey CCRI News & Events Archive
Scientific Reports: Patient-derived conditionally reprogrammed cells maintain intra-tumor genetic heterogeneity
March 6, 2018Bruna RS Correa, Joanna Hu, Luiz OF Penalva, Richard Schlegel, David L Rimm, Pedro AF Galante, Seema Agarwal Preclinical in vitro models provide an essential tool to study cancer cell biology as well as aid in translational research, including drug tar …
Molecular & Cellular Proteomics: Detection of proteome diversity resulted from alternative splicing is limited by trypsin cleavage specificity
March 1, 2018Xiaojing Wang, Simona G Codreanu, Bo Wen, Kai Li, Matthew C Chambers, Daniel C Liebler, Bing Zhang Alternative splicing dramatically increases transcriptome complexity but its contribution to proteome diversity remains controversial. Exon-exon junction …
Cell Stem Cell: Vangl2/RhoA Signaling Pathway Regulates Stem Cell Self-Renewal Programs and Growth in Rhabdomyosarcoma
March 1, 2018Madeline N Hayes 1, Karin McCarthy 1, Alexander Jin 1, Mariana L Oliveira 2, Sowmya Iyer 1, Sara P Garcia 1, Sivasish Sindiri 3, Berkley Gryder 3, Zainab Motala 4, G Petur Nielsen 5, Jean-Paul Borg 6, Matt van de Rijn 7, David Malkin 4, Javed Khan 3, M …
European Urology: Germline DNA-repair Gene Mutations and Outcomes in Men with Metastatic Castration-resistant Prostate Cancer Receiving First-line Abiraterone and Enzalutamide
February 10, 2018Emmanuel S.Antonarakisab†, ChangxueLub† BrandonLubera ChaoLiangb HaoWanga YanChenb John L.Silbersteinb DaniloPianab ZhaoLaic YidongChencd William B.Isaacsab JunLuoab Abstract Background Inherited DNA-repair gene mutations are more prevalent in men …
Cell Death & Disease: miR-195 targets cyclin D3 and survivin to modulate the tumorigenesis of non-small cell lung cancer
February 7, 2018Xiaojie Yu, Yiqiang Zhang, David Cavazos, Xiuye Ma, Zhenze Zhao, Liqin Du & Alexander Pertsemlidis Abstract miR-195 has recently been reported to function as a tumor suppressor in various cancers, including non-small cell lung cancer (NSCLC). Howev …
Bexar County Medical Society: Through cancer care and research, UT Health San Antonio serves South Texas’ most seriously ill children (Aune & Tomlinson Labs)
February 1, 2018Through cancer care and research, UT Health San Antonio serves South Texas’ most seriously ill children.
Bexar County Medical Society
February 1, 2018Childhood Obesity: Characterization of the Stool Microbiome in Hispanic Preschool Children by Weight Status and Time
February 1, 2018Emily B Hollister 1 2, Byron A Foster 3, Mahmoud Dahdouli 1 2, Jesica Ramirez 4, Zhao Lai 5 Abstract Background: Variations in gut microbiota composition and diversity have been associated with childhood adiposity, although most studies describing this …
Research Features: Battling brain tumours – novel therapies to treat astrocytomas
January 31, 2018The key mission of Greehey Children’s Cancer Research Institute is to advance scientific knowledge and develop novel therapies relevant to pediatric cancer. Their director, Dr. Peter Houghton, and his team work hard to further our understanding of sarc …
Atlas of Science: The position of the centromere is marked with ubiquitylation of CENP-A
January 30, 2018Chromosomes must segregate equally between daughter cells during cell division, and for proper chromosome segregation, spindle microtubules must attach to a single region of each chromosome, termed the “centromere,” in most eukaryotes. The kinetochore …