Greehey CCRI News & Events Archive

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PLOS One: Ubiquitin carboxyl-terminal esterase L1 (UCHL1) is associated with stem-like cancer cell functions in pediatric high-grade glioma

May 4, 2017

Patricia C. Sanchez-Diaz ,Judy C. Chang ,Emily S. Moses,Tu Dao,Yidong Chen,Jaclyn Y. Hung  Abstract Pediatric high-grade gliomas represent 8–12% of all primary tumors of the nervous system in children. Five-year survival for these pediatric aggressive …


Cancer Knowledge Network: Introducing Dr. Gregory Aune, Editor, Knowledge Translation: Childhood Cancer Survivorship

May 3, 2017

My patient experiences motivated me to pursue medicine and science.  I did so with the goal of improving outcomes for other cancer patients, once I had completed that long road.  But along the way, I began to consistently encounter health problems caus …


InderScience: Computational tools for genome-wide R-loops identification and characterization

April 15, 2017

Abstract: R-loops are physiologically occurring structures in the genome composed of a DNA/RNA hybrid and a displaced single-stranded DNA. R-loops have been observed in various organisms and shown to play important roles in regulating gene expression, …


International Journal of Computational Biology and Drug Design: Computational tools for genome-wide R-loops identification and characterisation

April 15, 2017

Authors: Rongjie Liu; Aparna Gorthi; Yufang Jin; Alexander J.R. Bishop; Yidong Chen Abstract: R-loops are physiologically occurring structures in the genome composed of a DNA/RNA hybrid and a displaced single-stranded DNA. R-loops have been observed in …


Axios: More people are surviving a cancer diagnosis

April 2, 2017

Survival rates for cancer patients in the U.S. continue to improve for many common types of the disease, according to a new report from top government agencies. Pancreatic, liver, brain, lung, and other cancers still have low rates of survival but pros …


BMC Genomics: Deep sequencing of HPV E6/E7 genes reveals loss of genotypic diversity and gain of clonal dominance in high-grade intraepithelial lesions of the cervix

March 14, 2017

Jane Shen-Gunther 1, Yufeng Wang 2, Zhao Lai 3, Graham M Poage 4, Luis Perez 4, Tim H M Huang 5 Abstract Background: Human papillomavirus (HPV) is the carcinogen of almost all invasive cervical cancer and a major cause of oral and other anogenital mali …


BMC Bioinformatics: Differential correlation analysis of glioblastoma reveals immune ceRNA interactions predictive of patient survival

February 28, 2017

Yu-Chiao Chiu, Li-Ju Wang, Tzu-Pin Lu, Tzu-Hung Hsiao, Eric Y. Chuang & Yidong Chen Abstract Background Recent studies illuminated a novel role of microRNA (miRNA) in the competing endogenous RNA (ceRNA) interaction: two genes (ceRNAs) can achieve …


AHA Journals – Circulation Research: Abstract 456: Early Doxorubicin Exposure Upregulates P-STAT3 Expression in Adult Murine Model

February 23, 2017

Tanoya L Harris and Gregory J Aune Abstract Background: Anthracyclines such as doxorubicin (DOX) is a key component of chemotherapy treatments and also have cardiotoxic effects that can manifest decades after initial exposure. Long term survivors have …


Journal of Biological Chemistry: An engineered transforming growth factor β (TGF-β) monomer that functions as a dominant negative to block TGF-β signaling

February 22, 2017

Sun Kyung Kim‡1, Lindsey Barron§, Cynthia S. Hinck¶, Elyse M. Petrunak¶, Kristin E. Cano‡, Avinash Thangirala‡, Brian Iskra‡, Molly Brothers‡, Machell Vonberg‡, Belinda Leal‡, Blair Richter‡, Ravindra Kodali¶, Alexander B. Taylor‡, Shoucheng Du¶, Chris …


Biochemistry: Confinement and Stabilization of Fyn SH3 Folding Intermediate Mimetics within the Cavity of the Chaperonin GroEL Demonstrated by Relaxation-Based NMR

February 21, 2017

David S Libich 1, Vitali Tugarinov 1, Rodolfo Ghirlando 1, G Marius Clore 1 Abstract The interaction of two folding intermediate mimetics of the model protein substrate Fyn SH3 with the chaperonin GroEL, a supramolecular foldase/unfoldase machine, has …