Greehey CCRI News & Events Archive

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Clinical Cancer Research: Bioluminescence Imaging Enhances Analysis of Drug Responses in a Patient-Derived Xenograft Model of Pediatric ALL

July 15, 2017

Luke Jones 1, Jennifer Richmond 1, Kathryn Evans 1, Hernan Carol 1, Duohui Jing 1, Raushan T Kurmasheva 2, Catherine A Billups 3, Peter J Houghton 2, Malcolm A Smith 4, Richard B Lock 5 Abstract Purpose: Robust preclinical models of pediatric acute lym …


Cancer Knowledge Network: New Biomarker Predicts Late Neurocognitive Deficits in Adult Survivors of Childhood Leukemia

July 13, 2017

THE RESEARCH: Journal of the National Cancer Institute:  Neurocognitive Sequelae in Adult Childhood Leukemia Survivors Related to Levels of Phosphorylated Tau.  Researchers compared intellectual performance, memory, and executive functioning between 31 …


Cancer Knowledge Network: Neurocognitive Function, Sleep, and Fatigue in Female Childhood ALL Survivors

July 6, 2017

THE RESEARCH: Cancer: Impact of sleep, fatigue, and systemic inflammation on neurocognitive and behavioral outcomes in long-term survivors of childhood acute lymphoblastic leukemia. Researchers at St. Jude Children’s Research Hospital compiled cohorts …


Clinical Cancer Research: Cancer Screening Recommendations and Clinical Management of Inherited Gastrointestinal Cancer Syndromes in Childhood

July 1, 2017

Maria Isabel Achatz, Christopher C. Porter, Laurence Brugières, Harriet Druker, Thierry Frebourg, William D. Foulkes, Christian P. Kratz, Roland P. Kuiper, Jordan R. Hansford, Hector Salvador Hernandez, Katherine L. Nathanson, Wendy K. Kohlmann, Leslie …


Clinical Cancer Research: Surveillance Recommendations for Children with Overgrowth Syndromes and Predisposition to Wilms Tumors and Hepatoblastoma

July 1, 2017

Jennifer M Kalish 1, Leslie Doros 2, Lee J Helman 3, Raoul C Hennekam 4, Roland P Kuiper 5, Saskia M Maas 6, Eamonn R Maher 7, Kim E Nichols 8, Sharon E Plon 9, Christopher C Porter 10, Surya Rednam 9, Kris Ann P Schultz 11, Lisa J States 12, Gail E To …


Clinical Cancer Research: Multiple Endocrine Neoplasia and Hyperparathyroid-Jaw Tumor Syndromes: Clinical Features, Genetics, and Surveillance Recommendations in Childhood

July 1, 2017

Jonathan D Wasserman 1, Gail E Tomlinson 2, Harriet Druker 3, Junne Kamihara 4, Wendy K Kohlmann 5, Christian P Kratz 6, Katherine L Nathanson 7, Kristian W Pajtler 8 9, Andreu Parareda 10, Surya P Rednam 11, Lisa J States 12, Anita Villani 3, Michael …


Cancer Knowledge Network: Chemotherapy More Effective at Causing Programmed Cell Death in Young Tissues

June 28, 2017

THE RESEARCH:  Cancer Cell:  Developmental Regulation of Mitochondrial Apoptosis by c-Myc Governs Age- and Tissue-Specific Sensitivity to Cancer Therapeutics.  Programmed cell death or apoptosis has been extensively studied in cancerous tissues and is …


Cancer Knowledge Network: Pregnancy in Female Cancer Survivors: Increased Risks for Mother and Baby

June 21, 2017

Journal of the National Cancer Institute: Pregnancy and Labor Complications in Female Survivors of Childhood Cancer:  The British Childhood Cancer Survivor Study.  Researchers in the United Kingdom compiled data on pregnancy complications including ges …


Cancer Knowledge Network: Decreased Therapy Results in Fewer Second Cancers

June 15, 2017

JAMA:  Temporal Trends in Treatment and Subsequent Neoplasm Risk Among 5-Year Survivors of Childhood Cancer, 1970-2015.  Investigators from the Childhood Cancer Survivor Study (CCSS) used longitudinal cohort data to compile the 15-year cumulative incid …


Cell Report: The NOTCH1/SNAIL1/MEF2C Pathway Regulates Growth and Self-Renewal in Embryonal Rhabdomyosarcoma

June 13, 2017

Myron S Ignatius 1, Madeline N Hayes 2, Riadh Lobbardi 2, Eleanor Y Chen 3, Karin M McCarthy 4, Prethish Sreenivas 5, Zainab Motala 6, Adam D Durbin 7, Aleksey Molodtsov 4, Sophia Reeder 4, Alexander Jin 4, Sivasish Sindiri 8, Brian C Beleyea 9, Deepak …


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