Greehey CCRI News & Events Archive

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PLOS One: Ubiquitin carboxyl-terminal esterase L1 (UCHL1) is associated with stem-like cancer cell functions in pediatric high-grade glioma

May 4, 2017

Patricia C. Sanchez-Diaz ,Judy C. Chang ,Emily S. Moses,Tu Dao,Yidong Chen,Jaclyn Y. Hung  Abstract Pediatric high-grade gliomas represent 8–12% of all primary tumors of the nervous system in children. Five-year survival for these pediatric aggressive …


Cancer Knowledge Network: Introducing Dr. Gregory Aune, Editor, Knowledge Translation: Childhood Cancer Survivorship

May 3, 2017

My patient experiences motivated me to pursue medicine and science.  I did so with the goal of improving outcomes for other cancer patients, once I had completed that long road.  But along the way, I began to consistently encounter health problems caus …


InderScience: Computational tools for genome-wide R-loops identification and characterization

April 15, 2017

Abstract: R-loops are physiologically occurring structures in the genome composed of a DNA/RNA hybrid and a displaced single-stranded DNA. R-loops have been observed in various organisms and shown to play important roles in regulating gene expression, …


International Journal of Computational Biology and Drug Design: Computational tools for genome-wide R-loops identification and characterisation

April 15, 2017

Authors: Rongjie Liu; Aparna Gorthi; Yufang Jin; Alexander J.R. Bishop; Yidong Chen Abstract: R-loops are physiologically occurring structures in the genome composed of a DNA/RNA hybrid and a displaced single-stranded DNA. R-loops have been observed in …


PloS One: De-regulated microRNAs in pediatric cancer stem cells target pathways involved in cell proliferation, cell cycle and development

April 4, 2017

Patricia C Sanchez-Diaz 1, Tzu-Hung Hsiao, Judy C Chang, Dong Yue, Mimi C Tan, Hung-I Harry Chen, Gail E Tomlinson, Yufei Huang, Yidong Chen, Jaclyn Y Hung Abstract Background: microRNAs (miRNAs) have been implicated in the control of many biological p …


Axios: More people are surviving a cancer diagnosis

April 2, 2017

Survival rates for cancer patients in the U.S. continue to improve for many common types of the disease, according to a new report from top government agencies. Pancreatic, liver, brain, lung, and other cancers still have low rates of survival but pros …


BMC Genomics: Deep sequencing of HPV E6/E7 genes reveals loss of genotypic diversity and gain of clonal dominance in high-grade intraepithelial lesions of the cervix

March 14, 2017

Jane Shen-Gunther 1, Yufeng Wang 2, Zhao Lai 3, Graham M Poage 4, Luis Perez 4, Tim H M Huang 5 Abstract Background: Human papillomavirus (HPV) is the carcinogen of almost all invasive cervical cancer and a major cause of oral and other anogenital mali …


Journal of Exposure Science & Environmental Epidemiology: Maternal and paternal occupational exposures and hepatoblastoma: results from the HOPE study through the Children’s Oncology Group

March 8, 2017

Amanda E Janitz, Gurumurthy Ramachandran, Gail E Tomlinson, Mark Krailo, Michaela Richardson & Logan Spector Abstract Little is known about the etiology of hepatoblastoma. We aimed to confirm the results of a previous study evaluating the associati …


BMC Bioinformatics: Differential correlation analysis of glioblastoma reveals immune ceRNA interactions predictive of patient survival

February 28, 2017

Yu-Chiao Chiu, Li-Ju Wang, Tzu-Pin Lu, Tzu-Hung Hsiao, Eric Y. Chuang & Yidong Chen Abstract Background Recent studies illuminated a novel role of microRNA (miRNA) in the competing endogenous RNA (ceRNA) interaction: two genes (ceRNAs) can achieve …


AHA Journals – Circulation Research: Abstract 456: Early Doxorubicin Exposure Upregulates P-STAT3 Expression in Adult Murine Model

February 23, 2017

Tanoya L Harris and Gregory J Aune Abstract Background: Anthracyclines such as doxorubicin (DOX) is a key component of chemotherapy treatments and also have cardiotoxic effects that can manifest decades after initial exposure. Long term survivors have …


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