Greehey CCRI News & Events Archive

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The American Journal of Pathology: Musashi1 Impacts Radio-Resistance in Glioblastoma by Controlling DNA-Protein Kinase Catalytic Subunit

May 20, 2016

Patricia Rosade Araujo∗†AparnaGorthi∗†Acarizia E.da Silva∗†Sonal S.Tonapi∗†Dat T.Vo∗†Suzanne C.Burns∗MeiQiao∗Philip J.Uren‡Zhi-MinYuan§Alexander J.R.Bishop∗†Luiz O.F.Penalva∗† The conserved RNA-binding protein Musashi1 (MSI1) has been characterized as …


Cancer Chemotherapy and Pharmacology: Identifying novel therapeutic agents using xenograft models of pediatric cancer

May 18, 2016

Raushan T. Kurmasheva & Peter J. Houghton Abstract In the USA, the overall cure rate for all childhood cancers is seventy percent, and in many patients that ultimately fail curative therapy, initial responses to current multimodality treatments (su …


Molecular Cancer Therapy: The Bromodomain BET Inhibitor JQ1 Suppresses Tumor Angiogenesis in Models of Childhood Sarcoma

May 15, 2016

Hemant K Bid 1, Doris A Phelps 1, Linlin Xaio 1, Denis C Guttridge 2, Jiayuh Lin 1, Cheryl London 3, Laurence H Baker 4, Xiaokui Mo 5, Peter J Houghton 6 Abstract The bromodomain and extra-terminal domain inhibitor JQ1 has marked antitumor activity aga …


Cancer & Zebrafish: In Vivo Imaging of Cancer in Zebrafish:

May 11, 2016

Myron S. Ignatius, Madeline Hayes, David M. Langenau Abstract Zebrafish cancer models have greatly advanced our understanding of malignancy in humans. This is made possible due to the unique advantages of the zebrafish model including ex vivo developme …


Dr. Yidong Chen awarded a $3.7M CPRIT Core facility award

May 1, 2016

In May 2016, Dr. Yidong Chen was awarded a $3.7M CPRIT Core facility award (RP160732) to upgrade and expand NGS capacity and further accelerate the adoption of high-throughput technology in translational cancer genetics and epigenetics research at UT H …


Biochimica et Biophysica Acta (BBA) – Molecular Basis of Disease: Vascular mTOR-dependent mechanisms linking the control of aging to Alzheimer’s disease

May 1, 2016

Abstract Aging is the strongest known risk factor for Alzheimer’s disease (AD). With the discovery of the mechanistic target of rapamycin (mTOR) as a critical pathway controlling the rate of aging in mice, molecules at the interface between the regulat …


Clinical Cancer Research: Recurrent Mutations of Chromatin-Remodeling Genes and Kinase Receptors in Pheochromocytomas and Paragangliomas

May 1, 2016

Rodrigo A. Toledo, Yuejuan Qin, Zi-Ming Cheng, Qing Gao, Shintaro Iwata, Gustavo M. Silva, Manju L. Prasad, I. Tolgay Ocal, Sarika Rao, Neil Aronin, Marta Barontini, Jan Bruder, Robert L. Reddick, Yidong Chen, Ricardo C.T. Aguiar and Patricia L.M. Dahi …


PLOS One: Combined Gene Expression and RNAi Screening to Identify Alkylation Damage Survival Pathways from Fly to Human

April 21, 2016

Alfeu Zanotto-Filho, Ravi Dashnamoorthy, Eva Loranc, Luis H. T. de Souza, José C. F. Moreira, Uthra Suresh, Yidong Chen, Alexander J. R. Bishop Abstract Alkylating agents are a key component of cancer chemotherapy. Several cellular mechanisms are known …


PLOS One: Combined Gene Expression and RNAi Screening to Identify Alkylation Damage Survival Pathways from Fly to Human

April 21, 2016

Alfeu Zanotto-Filho, Ravi Dashnamoorthy, Eva Loranc, Luis H. T. de Souza, José C. F. Moreira, Uthra Suresh, Yidong Chen, Alexander J. R. Bishop  Abstract Alkylating agents are a key component of cancer chemotherapy. Several cellular mechanisms are know …


JCI Insight: Synergism of FAK and tyrosine kinase inhibition in Ph+ B-ALL

April 17, 2016

Michelle L. Churchman,1 Kathryn Evans,2 Jennifer Richmond,2 Alissa Robbins,2 Luke Jones,2 Irina M. Shapiro,3 Jonathan A. Pachter,3 David T. Weaver,3 Peter J. Houghton,4 Malcolm A. Smith,5 Richard B. Lock,2 and Charles G. Mullighan1 Abstract BCR-ABL1+ B …