Greehey CCRI News & Events Archive

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Genes & Cancer: FGF19 functions as autocrine growth factor for hepatoblastoma

April 6, 2016

David J. Elzi1, Meihua Song1, Barron Blackman1, Susan T. Weintraub2, Dolores López-Terrada5, Yidong Chen1,3, Gail E. Tomlinson1,4 and Yuzuru Shiio1,2 ABSTRACT Hepatoblastoma is the most common liver cancer in children, accounting for over 65% of all ch …


RNA Biology: High-throughput analyses of hnRNP H1 dissects its multi-functional aspect

April 2, 2016

Authors Philip J Uren, Emad Bahrami-Samani, Patricia Rosa de Araujo, Christine Vogel, Mei Qiao, Suzanne C Burns, Andrew D Smith, Luiz OF Penalva hnRNPs are polyvalent RNA binding proteins that have been implicated in a range of regulatory roles includi …


Pediatric Blood & Cancer: Initial Testing of NSC 750854, a Novel Purine Analog, Against Pediatric Tumor Models by the Pediatric Preclinical Testing Program

March 1, 2016

Richard Gorlick 1, E Anders Kolb 2, Stephen T Keir 3, John M Maris 4, Richard B Lock 5, Hernan Carol 5, C Patrick Reynolds 6, Min H Kang 6, Catherine A Billups 7, Jerry Collins 8, Dias Kurmashev 9, Raushan T Kurmasheva 9, Peter J Houghton 9, Malcolm A …


Scientific Report: Roles of Distal and Genic Methylation in the Development of Prostate Tumorigenesis Revealed by Genome-wide DNA Methylation Analysis

February 29, 2016

Yao Wang 1, Rohit Ramakant Jadhav 1, Joseph Liu 1, Desiree Wilson 2, Yidong Chen 3, Ian M Thompson 4 5, Dean A Troyer 6, Javier Hernandez 4, Huidong Shi 7, Robin J Leach 2 4 5, Tim H-M Huang 1 5, Victor X Jin 1 3 Abstract Aberrant DNA methylation at pr …


Pediatric Blood & Cancer: Pharmacodynamic and genomic markers associated with response to the XPO1/CRM1 inhibitor selinexor (KPT-330): A report from the pediatric preclinical testing program

February 1, 2016

Edward F Attiyeh, John M Maris 1, Richard Lock 2, C Patrick Reynolds 3, Min H Kang 3, Hernan Carol 2, Richard Gorlick 4, E Anders Kolb 5, Stephen T Keir 6, Jianrong Wu 7, Yosef Landesman 8, Sharon Shacham 8, Dmitry Lyalin 9, Raushan T Kurmasheva 9, Pet …


IEEE: Cancer Progression Prediction Using Gene Interaction Regularized Elastic Net.

December 23, 2015

Lin Zhang; Hui Liu; Yufei Huang; Xuesong Wang; Yidong Chen; Jia Meng Abstract: Different types of genomic aberration may simultaneously contribute to tumorigenesis. To obtain a more accurate prognostic assessment to guide therapeutic regimen choice for …


Cure Today: The Circle of Life: Saving Fertility After Cancer

December 21, 2015

Cancer survivors have more options to save their fertility.  


Molecular Cancer Research: Intrinsic Resistance to Cixutumumab Is Conferred by Distinct Isoforms of the Insulin Receptor

December 1, 2015

Amelie Forest 1, Michael Amatulli 1, Dale L Ludwig 1, Christopher B Damoci 1, Ying Wang 1, Colleen A Burns 1, Gregory P Donoho 2, Nina Zanella 3, Heinz H Fiebig 3, Marie C Prewett 1, David Surguladze 1, James T DeLigio 1, Peter J Houghton 4, Malcolm A …


Genes & Cancer: The role of FLI-1-EWS, a fusion gene reciprocal to EWS-FLI-1, in Ewing sarcoma

November 7, 2015

David J. Elzi1, Meihua Song1, Peter J. Houghton1,2,3, Yidong Chen1,2,4, and Yuzuru Shiio1,2,5 ABSTRACT Ewing sarcoma is a cancer of the bone and soft tissue in children that is characterized by a chromosomal translocation involving EWS and an Ets famil …


Business Wire: Epizyme to Present New Scientific Data on the Role of HMT Inhibitors in Cancer

November 4, 2015

CAMBRIDGE, Mass.–(BUSINESS WIRE)–Epizyme, Inc. (NASDAQ: EPZM), a clinical-stage biopharmaceutical company creating novel epigenetic therapies for cancer patients, will present data from 11 accepted abstracts on the role of histone methyltransferase ( …