Greehey CCRI News & Events Archive

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Europe PMC: Alkylating Agent-Induced NRF2 Blocks Endoplasmic Reticulum Stress-Mediated Apoptosis via Control of Glutathione Pools and Protein Thiol Homeostasis.

September 15, 2016

Zanotto-Filho A1, Masamsetti VP1, Loranc E1, Tonapi SS1, Gorthi A1, Bernard X1, Gonçalves RM2, Moreira JC2, Chen Y1, Bishop AJ1 Abstract  Alkylating agents are a commonly used cytotoxic class of anticancer drugs. Understanding the mechanisms whereby ce …


European Journal of Medicinal Chemistry: 5,10b-Ethanophenanthridine amaryllidaceae alkaloids inspire the discovery of novel bicyclic ring systems with activity against drug resistant cancer cells

September 14, 2016

Author links open overlay panelAuthor links open overlay panelSean Henrya\, Ria Kidnera, Mary R.Reisenauera, Igor V .Magedova, Robert Kissb, Véronique Mathieub, Florence Lefrancc, Ramesh Dasarid, Antonio Evidentee, Xiaojie Yuf, Xiuye Maf, Alexander Per …


Hyundai Hope on Wheels Awards $250,000 Research Grant to Ut Health Science Center San Antonio in Honor of National Childhood Cancer Awareness Month

September 12, 2016

San Antonio, TX – September 12 – Hyundai Hope On Wheels® (HHOW) and San Antonio-area Hyundai dealers will present UT Health Science Center San Antonio with a $250,000 Scholar Grant to be used to improve care and increase treatment options for kids with …


The American Journal of Pathology: Musashi1 Impacts Radio-Resistance in Glioblastoma by Controlling DNA-Protein Kinase Catalytic Subunit

September 1, 2016

The conserved RNA-binding protein Musashi1 (MSI1) has been characterized as a stem cell marker, controlling the balance between self-renewal and differentiation and as a key oncogenic factor in numerous solid tumors, including glioblastoma. To explore …


UT Health SA Newsroom: Health Science Center, UTSA gain $4.6 million for cancer research

August 25, 2016

The Center for Innovative Drug Discovery (CIDD), a joint program of the UT Health Science Center San Antonio and The University of Texas at San Antonio (UTSA), is receiving a $4,598,728 grant from the Cancer Prevention & Research Institute of Texas …


BMC Genomics: Detection of high variability in gene expression from single-cell RNA-seq profiling

August 22, 2016

Hung-I Harry Chen, Yufang Jin, Yufei Huang & Yidong Chen Abstract Background The advancement of the next-generation sequencing technology enables mapping gene expression at the single-cell level, capable of tracking cell heterogeneity and determina …


BMC Genomics: A hierarchical model for clustering m6A methylation peaks in MeRIP-seq data

August 22, 2016

Xiaodong Cui, Jia Meng, Shaowu Zhang, Manjeet K. Rao, Yidong Chen & Yufei Huang Abstract Background The recent advent of the state-of-art high throughput sequencing technology, known as Methylated RNA Immunoprecipitation combined with RNA sequencin …


BMC Genomics: CrossLink: a novel method for cross-condition classification of cancer subtypes

August 22, 2016

Chifeng Ma, Konduru S. Sastry, Mario Flore, Salah Gehani, Issam Al-Bozom, Yusheng Feng, Erchin Serpedin, Lotfi Chouchane, Yidong Chen & Yufei Huang Abstract Background We considered the prediction of cancer classes (e.g. subtypes) using patient gen …


BMC Genomics: MBDDiff: an R package designed specifically for processing MBDcap-seq datasets

August 18, 2016

Yuanhang Liu,  Desiree Wilson,  Robin J. Leach   Yidong Chen  Abstract Background Since its initial discovery in 1975, DNA methylation has been intensively studied and shown to be involved in various biological processes, such as development, aging, an …


San Antonio Report: Commentary: Are Questions More Powerful Than Answers?

July 23, 2016

In the afternoon, the students had an opportunity to meet with Dr. Alexander Pertsemlidis, associate professor of pediatrics, hematology, and oncology at the Greehey Children’s Cancer Research Institute at the University of Texas Health Science Center. …


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