Greehey CCRI News & Events Archive

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PLOS One: Mice Fed Rapamycin Have an Increase in Lifespan Associated with Major Changes in the Liver Transcriptome

January 14, 2014

Wilson C. Fok, Yidong Chen, Alex Bokov, Yiqiang Zhang, Adam B. Salmon, Vivian Diaz, Martin Javors, William H. Wood 3rd, Yongqing Zhang, Kevin G. Becker, Viviana I. Pérez, Arlan Richardson  Abstract Rapamycin was found to increase (11% to 16%) the lifes …


Molecular Ecology Resources: Genomics of Compositae crops: reference transcriptome assemblies and evidence of hybridization with wild relatives

January 1, 2014

Kathryn A Hodgins 1, Zhao Lai, Luiz O Oliveira, David W Still, Moira Scascitelli, Michael S Barker, Nolan C Kane, Hannes Dempewolf, Alex Kozik, Richard V Kesseli, John M Burke, Richard W Michelmore, Loren H Rieseberg Abstract Although the Compositae ha …


Molecular Oncology: PELP1 oncogenic functions involve alternative splicing via PRMT6

December 30, 2013

Monica Mann, Yi Zou, Yidong Chen, Darrell Brann, Ratna Vadlamudi Abstract Proline‐, glutamic acid‐, and leucine‐rich protein 1 (PELP1) is a proto‐oncogene that functions as a coactivator of the estrogen receptor and is an independent prognostic predict …


Aging Cell: Combined treatment of rapamycin and dietary restriction has a larger effect on the transcriptome and metabolome of liver

December 13, 2013

Wilson C. Fok  Alex Bokov Jonathan Gelfond Zhen Yu Yiqiang Zhang Mark Doderer Yidong Chen Martin Javors William H. Wood III Yongqing Zhang Kevin G. Becker Arlan Richardson Viviana I. Pérez Summary Rapamycin (Rapa) and dietary restriction (DR) have cons …


BMC Systems Biology: BRCA-Monet: a breast cancer specific drug treatment mode-of-action network for treatment effective prediction using large scale microarray database

December 9, 2013

Chifeng Ma, Hung-I Harry Chen, Mario Flores, Yufei Huang & Yidong Chen Abstract Background Connectivity map (cMap) is a recently developed dataset and algorithm for uncovering and understanding the treatment effect of small molecules on different c …


Skeletal Muscle: Rb1 loss modifies but does not initiate alveolar rhabdomyosarcoma

November 25, 2013

Ken Kikuchi, Eri Taniguchi, Hung-I Harry Chen, Matthew N Svalina, Jinu Abraham, Elaine T Huang, Koichi Nishijo, Sean Davis, Christopher Louden, Lee Ann Zarzabal, Olivia Recht, Ayeza Bajwa, Noah Berlow, Mònica Suelves, Sherrie L Perkins, Paul S Meltzer, …


Proteome Science: Fully automated protein complex prediction based on topological similarity and community structure

November 7, 2013

Chengwei Lei, Saleh Tamim,  Alexander JR Bishop & Jianhua Ruan  Abstract To understand the function of protein complexes and their association with biological processes, a lot of studies have been done towards analyzing the protein-protein interact …


DNA Repair: Induction of homologous recombination following in utero exposure to DNA-damaging agents

November 1, 2013

Bijal Kariaab, Jo Ann Martinez, Alexander J.R.Bishop  Abstract Much of our understanding of homologous recombination, as well as the development of the working models for these processes, has been derived from extensive work in model organisms, such as …


EURASIP Journal on Bioinformatics and Systems Biology: Identification of genomic functional hotspots with copy number alteration in liver cancer

October 25, 2013

Tzu-Hung Hsiao, Hung-I Harry Chen, Stephanie Roessler, Xin Wei Wang & Yidong Chen Abstract Copy number alterations (CNAs) can be observed in most cancer patients. Several oncogenes and tumor suppressor genes with CNAs have been identified in differ …


Echocardiography: Cardiac Assessment in Pediatric Mice: Strain Analysis as a Diagnostic Measurement

September 19, 2013

Thomas G. Andrews M.Sc.,  Merry L. Lindsey Ph.D., Richard A. Lange M.D., M.B.A, Gregory J. Aune M.D., Ph.D. Abstract Echocardiography is a robust tool for assessing cardiac function in both humans and laboratory animals. Conventional echocardiographic …